Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie

Ziel: Die Computertomographie (CT) mit Kontrastmittel wird als Standardverfahren in der differentialdiagnostischen Abklärung von Atelektasen (AT) der Lunge eingesetzt. Ziel dieser Untersuchung war es, die diagnostische Treffsicherheit von B-Bild-Sonographie (US) und kontrastunterstützter Sonographi...

Ausführliche Beschreibung

Gespeichert in:
1. Verfasser: Brickmann, Christian
Beteiligte: Görg, C. (Prof. Dr. med.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Deutsch
Veröffentlicht: Philipps-Universität Marburg 2015
Innere Medizin
Ausgabe:http://dx.doi.org/10.17192/z2015.0625
Schlagworte:
Online Zugang:PDF-Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
first_indexed 2015-12-16T00:00:00Z
last_indexed 2015-12-16T23:59:59Z
oai_set_str_mv ddc:610
doc-type:doctoralThesis
open_access
xMetaDissPlus
dewey-raw 610
dewey-search 610
genre Medical sciences, Medicine
genre_facet Medical sciences, Medicine
topic_facet Medizin, Gesundheit
topic Medizin, Gesundheit
bronchial carcinoma
Ultraschall . Lunge
Ultraschall
CEUS
Kontrastunterstützte Ultraschalldiagnostik
Atelektase
Lung
Bronchialkarzinom
atelectasis
spellingShingle Medizin, Gesundheit
bronchial carcinoma
Ultraschall . Lunge
Ultraschall
CEUS
Kontrastunterstützte Ultraschalldiagnostik
Atelektase
Lung
Bronchialkarzinom
atelectasis
Brickmann, Christian
Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
Purpose: Transthoracic contrast enhanced ultrasound (CEUS) is the first line imaging method for the evaluation of thoracic lesions. We performed a retrospective study on patients with the aim to evaluate the performance of CEUS for the differentiation of central bronchial tumor formations (CTF) and focal lesions (FL) from tumor associated atelectasis (AT) in comparison to B-mode-sonography (US) and computed tomography (CT) as reference method. Material and Methods: N=47 patients with CTF and AT have been investigated via US and CEUS (Sonovue, Bracco) from May 2004 till December 2009. We evaluated if CTF and FL could be distinguished against the AT. Ultrasound evaluations were performed by 2 physicians, who were blinded for each other; discordant result were evaluated by a third physician. CT-pictures were evaluated blinded against sonographic results by a radiologist. Results: We could see significant difference favouring CEUS and CT against US for CTF differentiation, but no significant difference between CEUS and CT. CTF could be differentiated in 24/47 cases with US; in 38/47 cases with CEUS and in 34/47 cases in CT (US vs CEUS p=<0,05, US vs CT p=<0,05, CEUS vs CT p=0,38). FL could be seen with US in 6/47 cases, with CEUS in 15/47 cases and with CT in 8/47 cases (US vs CEUS p=<0,05, US vs CT p=0,69, CEUS vs CT p=0,09), showing a significant difference only for CEUS against US. Conclusion: CEUS is aquivalent to CT for the differentiation of an obstructive AT from CTF and more qualified than conventional US. We can even see a slight favoring of CEUS against CT.
format Dissertation
author Brickmann, Christian
license_str https://creativecommons.org/licenses/by-nc-sa/4.0
publishDate 2015
era_facet 2015
author2 Görg, C. (Prof. Dr. med.)
author2_role ths
description Ziel: Die Computertomographie (CT) mit Kontrastmittel wird als Standardverfahren in der differentialdiagnostischen Abklärung von Atelektasen (AT) der Lunge eingesetzt. Ziel dieser Untersuchung war es, die diagnostische Treffsicherheit von B-Bild-Sonographie (US) und kontrastunterstützter Sonographie (KUS) im Vergleich zur CT hinsichtlich der Abgrenzbarkeit einer zentralen Raumforderung (ZR) von atelektatischen Lungengewebe und im Nachweis von fokalen Läsionen (FL) in obstruktionsbedingten Lungenatelektasen zu untersuchen. Material und Methoden: Von Mai 2004 bis Dezember 2009 wurden n=47 Patienten mit histologisch gesichertem zentralem Bronchialkarzinom und obstruktiver Atelektase mit CT, US und KUS (Sonovue, Bracco) untersucht. Beurteilt wurden Abgrenzbarkeit von AT und ZR sowie Nachweis von FL in der AT. Die Ultraschallbilder von US und KUS wurden von 2 gegeneinander verblindeten Untersuchern beurteilt, diskrepante Befunde wurden drittbefundet. Die CT-Bilder wurden von einem verblindeten Radiologen beurteilt. Ergebnisse: Ein zentrale TU Darstellung gelang im US bei 24/47, in der KUS bei 38/47 und in der CT bei 34/47 der Patienten (US vs KUS p=<0,05, US vs CT p=<0,05, KUS vs CT p=0,38). Es zeigen sich signifikante Unterschiede zugunsten der KUS und der CT gegenüber dem US, nicht aber zwischen KUS und CT. Ein Nachweis von FL gelang im US bei 6/47, in der KUS bei 15/47 und in der CT bei 8/47 der Patienten (US vs KUS p=<0,05, US vs CT p=0,69, KUS vs CT p=0,09). Hier ist nur der Unterschied zwischen der KUS und dem US signifikant. Schlussfolgerung: Bei obstruktiver AT ist die KUS der CT in der Abgrenzung eines zentralen TU ebenbürtig und dem konventionellen US überlegen.
title_alt The value of contrast enhanced ultrasound (CEUS) compared to B-mode-sonography and the reference imaging technique contrast enhanced CT for the demarcation of a central bronchial carcinoma from a tumor associated atelectasis – a retrospective study
title Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
title_short Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
title_full Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
title_fullStr Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
title_full_unstemmed Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
title_sort Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie
ref_str_mv references
publisher Philipps-Universität Marburg
institution Innere Medizin
language German
building Medizin
url http://archiv.ub.uni-marburg.de/diss/z2015/0625/pdf/dcb.pdf
contents Purpose: Transthoracic contrast enhanced ultrasound (CEUS) is the first line imaging method for the evaluation of thoracic lesions. We performed a retrospective study on patients with the aim to evaluate the performance of CEUS for the differentiation of central bronchial tumor formations (CTF) and focal lesions (FL) from tumor associated atelectasis (AT) in comparison to B-mode-sonography (US) and computed tomography (CT) as reference method. Material and Methods: N=47 patients with CTF and AT have been investigated via US and CEUS (Sonovue, Bracco) from May 2004 till December 2009. We evaluated if CTF and FL could be distinguished against the AT. Ultrasound evaluations were performed by 2 physicians, who were blinded for each other; discordant result were evaluated by a third physician. CT-pictures were evaluated blinded against sonographic results by a radiologist. Results: We could see significant difference favouring CEUS and CT against US for CTF differentiation, but no significant difference between CEUS and CT. CTF could be differentiated in 24/47 cases with US; in 38/47 cases with CEUS and in 34/47 cases in CT (US vs CEUS p=<0,05, US vs CT p=<0,05, CEUS vs CT p=0,38). FL could be seen with US in 6/47 cases, with CEUS in 15/47 cases and with CT in 8/47 cases (US vs CEUS p=<0,05, US vs CT p=0,69, CEUS vs CT p=0,09), showing a significant difference only for CEUS against US. Conclusion: CEUS is aquivalent to CT for the differentiation of an obstructive AT from CTF and more qualified than conventional US. We can even see a slight favoring of CEUS against CT.
doi_str_mv http://dx.doi.org/10.17192/z2015.0625
edition http://dx.doi.org/10.17192/z2015.0625
thumbnail http://archiv.ub.uni-marburg.de/diss/z2015/0625/cover.png
spelling diss/z2015/0625 2015-12-16 2015-11-24 2015 Ziel: Die Computertomographie (CT) mit Kontrastmittel wird als Standardverfahren in der differentialdiagnostischen Abklärung von Atelektasen (AT) der Lunge eingesetzt. Ziel dieser Untersuchung war es, die diagnostische Treffsicherheit von B-Bild-Sonographie (US) und kontrastunterstützter Sonographie (KUS) im Vergleich zur CT hinsichtlich der Abgrenzbarkeit einer zentralen Raumforderung (ZR) von atelektatischen Lungengewebe und im Nachweis von fokalen Läsionen (FL) in obstruktionsbedingten Lungenatelektasen zu untersuchen. Material und Methoden: Von Mai 2004 bis Dezember 2009 wurden n=47 Patienten mit histologisch gesichertem zentralem Bronchialkarzinom und obstruktiver Atelektase mit CT, US und KUS (Sonovue, Bracco) untersucht. Beurteilt wurden Abgrenzbarkeit von AT und ZR sowie Nachweis von FL in der AT. Die Ultraschallbilder von US und KUS wurden von 2 gegeneinander verblindeten Untersuchern beurteilt, diskrepante Befunde wurden drittbefundet. Die CT-Bilder wurden von einem verblindeten Radiologen beurteilt. Ergebnisse: Ein zentrale TU Darstellung gelang im US bei 24/47, in der KUS bei 38/47 und in der CT bei 34/47 der Patienten (US vs KUS p=<0,05, US vs CT p=<0,05, KUS vs CT p=0,38). Es zeigen sich signifikante Unterschiede zugunsten der KUS und der CT gegenüber dem US, nicht aber zwischen KUS und CT. Ein Nachweis von FL gelang im US bei 6/47, in der KUS bei 15/47 und in der CT bei 8/47 der Patienten (US vs KUS p=<0,05, US vs CT p=0,69, KUS vs CT p=0,09). Hier ist nur der Unterschied zwischen der KUS und dem US signifikant. Schlussfolgerung: Bei obstruktiver AT ist die KUS der CT in der Abgrenzung eines zentralen TU ebenbürtig und dem konventionellen US überlegen. The value of contrast enhanced ultrasound (CEUS) compared to B-mode-sonography and the reference imaging technique contrast enhanced CT for the demarcation of a central bronchial carcinoma from a tumor associated atelectasis – a retrospective study Stellenwert der kontrastmittelunterstützten Sonographie (CEUS) im Vergleich zur konventionellen B-Bild Sonographie und der Referenzprozedur (KM-CT) in der Abgrenzung eines zentralen Lungentumors von einer nachgeschalteten Atelektase: eine retrospektive Studie Boffetta, P. and F. Nyberg (2003). "Contribution of environmental factors to cancer risk." British Medical Bulletin 68: 71-94. 2003 Contribution of environmental factors to cancer risk Riede, U., et al. (2009). Basiswissen Allgemeine und Spezielle Pathologie, Springer Verlag, Berlin -Heidelberg. 2009 Basiswissen Allgemeine und Spezielle Pathologie Schmidt, G. (2004). Kursbuch Ultraschall, Thieme Verlag, Stuttgart. 2004 Kursbuch Ultraschall Burns, P. N. (1996). "Harmonic imaging with ultrasound contrast agents." Clinical Radiology 51: 50-55. 1996 Harmonic imaging with ultrasound contrast agents Brambilla, E., et al. (2001). "The new World Health Organization classification of lung tumours." European Respiratory Journal 18(6): 1059-1068. 2001 The new World Health Organization classification of lung tumours Schwenzer, N., et al. (2000). Computertomographie, Magnetresonanztherapie und Angiographie. Algemeine Chirurgie, Thieme, Stuttgart. 1. 2000 Computertomographie, Magnetresonanztherapie und Angiographie Correas, J. M., et al. (2001). "Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts." European Radiology 11(8): 1316-1328. 2001 Ultrasound contrast agents: properties, principles of action, tolerance, and artifacts Piscaglia, F., et al. (2006). "The safety of Sonovue (R) in abdominal applications: Retrospective analysis of 23188 investigations." Ultrasound in Medicine and Biology 32(9): 1369-1375. 2006 The safety of Sonovue (R) in abdominal applications: Retrospective analysis of 23188 investigations Blomley, M., et al. (2007). "WFUMB safety symposium on ultrasound contrast agents: Clinical applications and safety concerns." Ultrasound in Medicine and Biology 33(2): 180- 186. 2007 WFUMB safety symposium on ultrasound contrast agents: Clinical applications and safety concerns de Jong, N., et al. (2000). "Optical imaging of contrast agent microbubbles in an ultrasound field with a 100-MHz camera." Ultrasound in Medicine and Biology 26(3): 487- 492. 2000 Optical imaging of contrast agent microbubbles in an ultrasound field with a 100-MHz camera Muller, N., et al. (2001). Radiologic diagnosis of diseases of the chest, Saunders. 2001 Radiologic diagnosis of diseases of the chest Görg, C., et al. (2006). "Transcutaneous contrast enhanced sonography of the chest for evaluation of pleural based pulmonary lesions: experience in 137 patients." Ultraschall in der Medizin (Stuttgart, Germany : 1980) 27(5): 437-444. 1980 Transcutaneous contrast enhanced sonography of the chest for evaluation of pleural based pulmonary lesions: experience in 137 patients Shepherd, F. A., et al. (2007). "The International Association for the study of Lung Cancer - Lung Cancer staging project: Proposals regarding the clinical staging of small cell Lung Cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for Lung Cancer." Journal of Thoracic Oncology 2(12): 1067-1077. 2007 The International Association for the study of Lung Cancer - Lung Cancer staging project: Proposals regarding the clinical staging of small cell Lung Cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for Lung Cancer Forsberg, F., et al. (1999). "Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma." Radiology 210(1): 125-132. 1999 Tissue-specific US contrast agent for evaluation of hepatic and splenic parenchyma Görg, C. and T. Bert (2006). "Second-generation sonographic contrast agent for differential diagnosis of perisplenic lesions." American Journal of Roentgenology 186(3): 621-626. 2006 Second-generation sonographic contrast agent for differential diagnosis of perisplenic lesions Thun, M. J., et al. (2008). "Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 2008 Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 Bittner, R. C. and R. Felix (1998). "Magnetic resonance (MR) imaging of the chest: state-of- the-art." European Respiratory Journal 11(6): 1392-1404. 1998 Magnetic resonance (MR) imaging of the chest: state-ofthe-art Wen, Q., et al. (2008). "Enhancement pattern of peripheral lung carcinoma:comparison between contrast-enhanced ultrasonography and contrast-enhanced computed tomography." Zhonghua yi xue za zhi 88(39): 2779-2782. 2008 Enhancement pattern of peripheral lung carcinoma:comparison between contrast-enhanced ultrasonography and contrast-enhanced computed tomography Linde, H. N. G., et al. (2012). "Contrast-Enhancend Sonography (CEUS) in Pneumonia: Typical Patterns and Clinical Value -a Retrospective Study on n=50 Patients." Ultraschall in Der Medizin 33(2): 146-151. 2012 Contrast-Enhancend Sonography (CEUS) in Pneumonia: Typical Patterns and Clinical Value -a Retrospective Study on n=50 Patients Lippert, H. (2003). Lehrbuch Anatomie. Hannover, Elsevier GmbH, München. 2003 Lehrbuch Anatomie Tamura, A., et al. (1998). "Lipoid pneumonia in lung cancer: Radiographic and pathological features." Japanese Journal of Clinical Oncology 28(8): 492-496. 1998 Lipoid pneumonia in lung cancer: Radiographic and pathological features Görg, C., et al. (2005). "Contrast-enhanced sonography for differential diagnosis of pleurisy and focal pleural lesions of unknown cause." Chest 128(6): 3894-3899. 2005 Contrast-enhanced sonography for differential diagnosis of pleurisy and focal pleural lesions of unknown cause Detterbeck, F. C., et al. (2013). "Executive Summary Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines." Chest 143(5): 7S-37S. 2013 Executive Summary Diagnosis and Management of Lung Cancer American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Gramiak, R. and P. M. Shah (1968). "Echocardiography of the aortic root." Invest Radiol 3(5): 356-366. 1968 Echocardiography of the aortic root Morel, D. R., et al. (2000). "Human pharmacokinetics and safety evaluation of SonoVue (TM), a new contrast agent for ultrasound imaging." Investigative Radiology 35(1): 80-85. 2000 Human pharmacokinetics and safety evaluation of SonoVue (TM), a new contrast agent for ultrasound imaging Bauer, A., et al. (1999). "Wideband harmonic imaging: A novel contrast ultrasound imaging technique." European Radiology 9: S364-S367. 1999 Wideband harmonic imaging: A novel contrast ultrasound imaging technique Mathis, G. (2010). Bildatlas der Lungen-und Pleurasonographie, Springer Verlag. 2010 Bildatlas der Lungen-und Pleurasonographie Spitz, M. (2006). Cancer of the lung. Cancer Epidemiology and Prevention, Oxford University Press. 3rd Edition. 2006 Cancer of the lung. Cancer Epidemiology and Prevention Cohorts and 22 Cancer Registry Studies." Plos Medicine 5(9): 1357-1371. Cohorts and 22 Cancer Registry Studies Lissner, J., et al. (1992). Grundlagen der radiologischen Diagnostik. Radiologie, Enke, Stuttgart. 1992 Grundlagen der radiologischen Diagnostik Claudon, M., et al. (2008). "Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) -Update 2008." Ultraschall in Der Medizin 29(1): 28- 44. 2008 Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) -Update 2008 Herold, G. (2009). Herold -Innere Medizin. Köln, Gerd Herold. 2009 Herold -Innere Medizin Rivera, M. P. and A. C. Mehta (2007). "Initial diagnosis of lung cancer -ACCP evidence- based clinical practice guidelines (2nd edition)." Chest 132(3): 131S-148S. 2007 Initial diagnosis of lung cancer -ACCP evidencebased clinical practice guidelines Schwaiblmair, M., et al. (2010). "Lipoid pneumonia -an underestimated syndrome?" Deutsche Medizinische Wochenschrift 135(1-2): 27-31. 2010 Lipoid pneumonia -an underestimated syndrome? Loose, R. (2008). Orientierungshilfe für bildgebende Untersuchungen -Empfehlung der Strahlenschutzkommission. Bonn, Strahlenschutzkommission Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit. 2008 Orientierungshilfe für bildgebende Untersuchungen -Empfehlung der Strahlenschutzkommission Görg, C. (2008). Perkutane kontrastunterstützte Sonographie am Thorax, Verlag Robert Gessler. 2008 Perkutane kontrastunterstützte Sonographie am Thorax Olschewski, H., et al. (1999). "Physiology and pathophysiology of pulmonary circulation." Internist 40(7): 696-709. 1999 Physiology and pathophysiology of pulmonary circulation Burns, P. N., et al. (2000). "Pulse inversion imaging of liver blood flow -Improved method for characterizing focal masses with microbubble contrast." Investigative Radiology 35(1): 58-71. 2000 Pulse inversion imaging of liver blood flow -Improved method for characterizing focal masses with microbubble contrast Thomas, M., et al. (2000). "Recommendations on the diagnosis of bronchial carcinoma. 2000 Recommendations on the diagnosis of bronchial carcinoma Rott, H. D. (1999). "Safety of ultrasonic contrast agents. European Committee for Medical Ultrasound Safety." Eur J Ultrasound 9(2): 195-197. 1999 Safety of ultrasonic contrast agents. European Committee for Medical Ultrasound Safety NIH, U. (2010) SEER Cancer Statistics Review 1975-2006SEER Cancer Statistics Review 1975- 2006. 1975 SEER Cancer Statistics Review 1975-2006SEER Cancer Statistics Review Eltorky, M., et al. (1990). "SIGNIFICANT CHANGES IN THE DISTRIBUTION OF HISTOLOGIC TYPES OF LUNG-CANCER -A REVIEW OF 4928 CASES." Cancer 65(10): 2361-2367. 1990 SIGNIFICANT CHANGES IN THE DISTRIBUTION OF HISTOLOGIC TYPES OF LUNG-CANCER -A REVIEW OF 4928 CASES Putz, R. and R. Pabst (2000). Sobotta -Atlas der Anatomie des Menschen. München, Urban und Fischer Verlag. 2000 Sobotta -Atlas der Anatomie des Menschen Cao, B.-S., et al. (2011). "Sonographically Guided Transthoracic Biopsy of Peripheral Lung and Mediastinal Lesions Role of Contrast-Enhanced Sonography." Journal of Ultrasound in Medicine 30(11): 1479-1490. 2011 Sonographically Guided Transthoracic Biopsy of Peripheral Lung and Mediastinal Lesions Role of Contrast-Enhanced Sonography Blomley, M., et al. (1998). "Stimulated acoustic emission imaging ("sono-scintigraphy") with the ultrasound contrast agent Levovist: A reproducible Doppler ultrasound effect with potential clinical utility." Academic Radiology 5: S236-S239. 1998 Stimulated acoustic emission imaging ("sono-scintigraphy") with the ultrasound contrast agent Levovist: A reproducible Doppler ultrasound effect with potential clinical utility Goldstraw, P., et al. (2007). "The IASLC lung cancer staging project: Proposals for the revision of he TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours." Journal of Thoracic Oncology 2(8): 706-714. 2007 The IASLC lung cancer staging project: Proposals for the revision of he TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours Grouven, U., et al. (2007). "The kappa coefficient." Deutsche medizinische Wochenschrift (1946) 132 Suppl 1: e65-68. 1946 The kappa coefficient Becker, H., et al. (2004). Therapie des kleinzelligen Lungenkarzinom -Interdisziplinäre Leitlinie der Deutschen Krebsgesellschaft, AWMF online. Nr. 032/006. 2004 Therapie des kleinzelligen Lungenkarzinom -Interdisziplinäre Leitlinie der Deutschen Krebsgesellschaft Detterbeck, F. C., et al. (2013). "The Stage Classification of Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence- Based Clinical Practice Guidelines." Chest 143(5): E191-E210. 2013 The Stage Classification of Lung Cancer Diagnosis and Management of Lung Cancer American College of Chest Physicians Evidence- Based Clinical Practice Guidelines Görg, C. and T. Bert (2004). "Transcutaneous colour Doppler Sonography of lung consolidations: Review and pictorial essay part 1: Pathophysiologic and colour Doppler sonographic basics of pulmonary vascularity." Ultraschall in Der Medizin 25(3): 221-226. 2004 Transcutaneous colour Doppler Sonography of lung consolidations: Review and pictorial essay part 1: Pathophysiologic and colour Doppler sonographic basics of pulmonary vascularity Krogel, C. and A. Reissig (1999). Transthorakale Sonographie, Thieme, Stuttgart (1999). 1999 Transthorakale Sonographie, Thieme Dietrich, C. F., et al. (2003). "Ultrasonography of pleura and lung." Ultraschall in Der Medizin 24(5): 303-311. 2003 Ultrasonography of pleura and lung Krestan, C. (2005). "Ultrasound contrast agents: substance classes, pharmacokinetics, clinical indications, safety profile." Radiologe 45(6): 513-519. 2005 Ultrasound contrast agents: substance classes, pharmacokinetics, clinical indications, safety profile Ulmer, W., et al. (1991). Die Lungenfunktion, Physiologie und Pathophysiologie, Methodik, Georg Thieme Verlag -Stuttgart -New York. 1991 Die Lungenfunktion Jemal, A., et al. (2011). "Global cancer statistics." CA: a cancer journal for clinicians 61(2): 69-90. 2011 Global cancer statistics Duncker, H. and W. Kummer (2008). Anatomie, Elsevier Verlag München. 2008 Anatomie Schlungbaum, W., et al. (1994). Medizinische Strahlenkunde. Medizinische Strahlenkunde, DeGruyter, Berlin -New York. 1994 Medizinische Strahlenkunde Hsu, W. H., et al. (1996). "Color Doppler ultrasound signals of thoracic lesions -Correlation with resected histologic specimens." American Journal of Respiratory and Critical Care Medicine 153(6): 1938-1951. 1996 Color Doppler ultrasound signals of thoracic lesions -Correlation with resected histologic specimens Görg, C., et al. (2005). "Colour Doppler ultrasound mapping of chest wall lesions." British Journal of Radiology 78(928): 303-307. 2005 Colour Doppler ultrasound mapping of chest wall lesions Lam, W. K., et al. (2004). "Lung cancer epidemiology and risk factors in Asia and Africa." International Journal of Tuberculosis and Lung Disease 8(9): 1045-1057. 2004 Lung cancer epidemiology and risk factors in Asia and Africa Görg, C., et al. (2003). "Color Doppler sonographic mapping of pulmonary lesions - Evidence of dual arterial supply by spectral analysis." Journal of Ultrasound in Medicine 22(10): 1033-1039. 2003 Color Doppler sonographic mapping of pulmonary lesions - Evidence of dual arterial supply by spectral analysis Görg, C., et al. (2006). "Contrast-enhanced sonography of the lung for differential diagnosis of atelectasis." Journal of Ultrasound in Medicine 25(1): 35-39. 2006 Contrast-enhanced sonography of the lung for differential diagnosis of atelectasis Nakanishi, M., et al. (2008). "Multi-arterial infusion chemotherapy for non-small cell lung carcinoma -Significance of detecting feeding arteries and tumor staining." Lung Cancer 61(2): 227-234. 2008 Multi-arterial infusion chemotherapy for non-small cell lung carcinoma -Significance of detecting feeding arteries and tumor staining Bachmann, C. and C. Gorg (2005). "Color Doppler sonographic findings in focal spleen lesions." European Journal of Radiology 56(3): 386-390. 2005 Color Doppler sonographic findings in focal spleen lesions Wardlaw, J. M., et al. (2002). "Interobserver variability of magnetic resonance angiography in the diagnosis of carotid stenosis -effect of observer experience." Neuroradiology 44(2): 126-132. 2002 Interobserver variability of magnetic resonance angiography in the diagnosis of carotid stenosis -effect of observer experience Mornstein, V. (1997). "Cavitation-induced risks associated with contrast agents used in ultrasonography." European Journal of Ultrasound 5(2): 101-111. 1997 Cavitation-induced risks associated with contrast agents used in ultrasonography Sant, M., et al. (2009). "EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary." European Journal of Cancer 45(6): 931-991. 2009 EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary Ye, X.-D., et al. (2013). "Assessment of the feeding arteries by three-dimensional computed tomography angiography prior to multi-arterial infusion chemotherapy for lung cancer." Oncology Letters 5(1): 363-367. 2013 Assessment of the feeding arteries by three-dimensional computed tomography angiography prior to multi-arterial infusion chemotherapy for lung cancer Detterbeck, F. C., et al. (2009). "The New Lung Cancer Staging System." Chest 136(1): 260- 271. 2009 The New Lung Cancer Staging System Jakobsen, J. A., et al. (2005). "Safety of ultrasound contrast agents." European Radiology 15(5): 941-945. 2005 Safety of ultrasound contrast agents Purpose: Transthoracic contrast enhanced ultrasound (CEUS) is the first line imaging method for the evaluation of thoracic lesions. We performed a retrospective study on patients with the aim to evaluate the performance of CEUS for the differentiation of central bronchial tumor formations (CTF) and focal lesions (FL) from tumor associated atelectasis (AT) in comparison to B-mode-sonography (US) and computed tomography (CT) as reference method. Material and Methods: N=47 patients with CTF and AT have been investigated via US and CEUS (Sonovue, Bracco) from May 2004 till December 2009. We evaluated if CTF and FL could be distinguished against the AT. Ultrasound evaluations were performed by 2 physicians, who were blinded for each other; discordant result were evaluated by a third physician. CT-pictures were evaluated blinded against sonographic results by a radiologist. Results: We could see significant difference favouring CEUS and CT against US for CTF differentiation, but no significant difference between CEUS and CT. CTF could be differentiated in 24/47 cases with US; in 38/47 cases with CEUS and in 34/47 cases in CT (US vs CEUS p=<0,05, US vs CT p=<0,05, CEUS vs CT p=0,38). FL could be seen with US in 6/47 cases, with CEUS in 15/47 cases and with CT in 8/47 cases (US vs CEUS p=<0,05, US vs CT p=0,69, CEUS vs CT p=0,09), showing a significant difference only for CEUS against US. Conclusion: CEUS is aquivalent to CT for the differentiation of an obstructive AT from CTF and more qualified than conventional US. We can even see a slight favoring of CEUS against CT. urn:nbn:de:hebis:04-z2015-06257 http://dx.doi.org/10.17192/z2015.0625 opus:6452 Brickmann, Christian Brickmann Christian ths Prof. Dr. med. Görg C. Görg, C. (Prof. Dr. med.) Philipps-Universität Marburg
recordtype opus
id urn:nbn:de:hebis:04-z2015-0625
urn_str urn:nbn:de:hebis:04-z2015-06257
collection Monograph
uri_str http://archiv.ub.uni-marburg.de/diss/z2015/0625
callnumber-raw diss/z2015/0625
callnumber-search diss/z2015/0625
callnumber-sort diss/z2015/0625
callnumber-label diss z2015 0625
callnumber-first diss
callnumber-subject diss z2015
_version_ 1563294020919099392
score 9,599496