Synthesis, Identification, Kinetic, and Structural Characterization of Inhibitors of the Aspartic Proteases HTLV-1 Protease and Endothiapepsin

Synthesis, Identification, Kinetic, and Structural Characterization of Inhibitors of the Aspartic Proteases HTLV-1 Protease and Endothiapepsin

This thesis focuses on the identification and synthesis as well as kinetic and structural characterization of non-peptidic small molecule inhibitors of the two aspartic proteases HTLV-1 protease (HTLV-1 PR) and endothiapepsin. The HTLV-1 PR, a promising target for the treatment of viral infections...

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Bibliografiska uppgifter
Huvudupphovsman: Kuhnert, Maren Sophia
Övriga upphovsmän: Diederich, Wibke (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Materialtyp: Dissertation
Språk:engelska
Publicerad: Philipps-Universität Marburg 2015
Ämnen:
Wirkstoffdesign
aspartic proteases
enzyme inhibitor
Inhibitor
Enzym
Proteinkristallographie
drug design
X-ray crystallography
Medizin
Aspartylproteasen
Indinavir
Proteasen
HTLV-1-Proteaseinhibitor
Medical sciences Medicine
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