Effekte von Flavopiridol, Bortezomib und MG-115 in Kombination mit Carboplatin auf Ovarialkarzinom-Zelllinien in vitro

An den beiden Ovarialkarzinomzelllinien SKOV-3 und BG1 wurden neben dem bereits in der Therapie etablierten Carboplatin die Proteasomen-Inhibitoren Bortezomib und MG-115 und der CDK-Inhibitor Flavopiridol mittels Durchflusszytometrie auf ihre antiproliferative Wirkung untersucht. Dabei konnte im Rah...

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Bibliographic Details
Main Author: Kranz, Julia
Contributors: Wagner, Uwe (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2014
Frauenheilkunde und Geburtshilfe
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33. Abb. 28 Auswertung Annexin-V-Assay der BG1-Zellen nach Inkubation mit 1µmol Flavopiridol und Zugabe von 25µmol Carboplatin 63


34. Abb. 29 Änderung derZellvitalität der BG1-Zelllinie 65


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37. Abb. 32 Western Blot-Analyse Caspasen 3


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39. Abb. 34 Western Blot-Analyse Cytochrom C bei SKOV-3-Zellen 69


40. Abb. 35 Western Blot-Analyse Cytochrom C bei BG1-Zellen 70


41. Abb. 36 relative Änderung der NfĸB-Aktivität der SKOV-3-Zelllinie 71


42. Abb. 37 relative Änderung der NfĸB-Aktivität der BG1-Zelllinie 72


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