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Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization
The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...
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| Format: | Dissertation |
| Langue: | anglais |
| Publié: |
Philipps-Universität Marburg
2014
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| Accès en ligne: | Texte intégral en PDF |
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