Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

Investigations on lin-Benzopurines With Respect to Dissociation Behavior, Pocket Cross-Talk, Targeting Resistance Mutants, Residual Mobility, and Scaffold Optimization

The present thesis deals with the characterization and improvement of selective antibiotics targeting the enzyme tRNA–guanine transglycosylase. Recently, the lin-benzopurine scaffold was introduced as promising starting point for the structure-based design of TGT inhibitors. Two classes, namely the...

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Bibliografische gegevens
Hoofdauteur: Neeb, Manuel
Andere auteurs: Klebe, Gerhard (Prof. Dr.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2014
Onderwerpen:
isothermal titration calorimetry
Wirkstoffdesign
transferase
Transferase
Enzyminhibition
Isothermale Titrationskalorimetrie
enzyme inhibition
X-ray crystallography
Medizin
Proteinkristallographie
drug design
Medical sciences Medicine
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Plaatsingsnummer: urn:nbn:de:hebis:04-z2014-04196
Publicatiedatum: 2014-11-18
Datum der Annahme: 2014-11-05
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL naar item: https://archiv.ub.uni-marburg.de/diss/z2014/0419
https://doi.org/10.17192/z2014.0419

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