Gelatin Nanoparticles as Potential Nanocarriers for Macromolecular Drugs

With an objective of designing gelatin based nanoparticulate delivery system for macromolecules, some of the important challenges associated with gelatin nanoparticles are addressed in this thesis. The first goal is to avoid aggregation, one of the most often encountered problems during nanoparticl...

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Bibliographic Details
Main Author: Khan, Saeed Ahmad
Contributors: Schneider, Marc (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2014
Pharmazeutische Technologie und Biopharmazie
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1. Saeed Ahmad Khan, Marc Schneider, Improvement of Nanoprecipitation Technique for Preparation of Gelatin Nanoparticles and Potential Macromolecular Drug Loading. Macromolecular Bioscience,2013, 13(4):455-63.


2. Saeed Ahmad Khan, Marc Schneider, Stabilization of gelatin nanoparticles without crosslinking, Submitted. Macromolecular Bioscience, submitted.


3. Mohanty, B., et al., Length Scale Hierarchy in Sol, Gel, and Coacervate Phases of Gelatin. Journal of Polymer Science: Part B: Polymer Physics, 2006. 44: p. 1653-1667.


4. Mohanty, B., et al., Small-angle neutron and dynamic light scattering study of gelatin coacervates. Indian Academy of Sciences, 2005. 63(2): p. 271-276.


5. Vandervoort, J. and A. Ludwig, Preparation and evaluation of drug-loaded gelatin nanoparticles for topical ophthalmic use. European Journal of Pharmaceutics and Biopharmaceutics, 2004. 57(2): p. 251-261.


6. Bajpai, A. and J. Choubey, Release study of sulphamethoxazole controlled by swelling of gelatin nanoparticles and drug-biopolymer interaction. Journal of macromolecular science. Pure and applied chemistry, 2005. 42(3): p. 253-275.


7. Poster Presentation


8. Saeed Ahmad Khan, Marc Schneider, Nanoprecipitation versus two step desolvation technique for the preparation of gelatin nanoparticles, SPIE conference proceedings volume:8595 (Colloidal Nanocrystals for Biomedical Applications VIII, 2013).


9. Leo, E., et al., General and cardiac toxicity of doxorubicin-loaded gelatin nanoparticles. Il Farmaco, 1997. 52(6-7): p. 385-388.


10. Kaul, G. and M. Amiji, Biodistribution and targeting potential of poly (ethylene glycol)- modified gelatin nanoparticles in subcutaneous murine tumor model. Journal of drug


11. Hornig, S., et al., Synthetic polymeric nanoparticles by nanoprecipitation. Journal of Materials Chemistry, 2009. 19(23): p. 3838-3840.


12. Saeed Ahmad Khan, Marc Schneider, Crosslinked gelatin nanoparticles for the delivery of macromolecules, CRS local chapter meeting, 27-28 Feb. 2014, University of Kiel, Germany.


13. Delivery of antibiotics by nanospheres prepared by MJR technology (with MJR PharmJet GmbH, in preparation).


14. Saeed Ahmad Khan, Marc Schneider, Effect of molecular weight on encapsulation and release of macromolecular drugs from gelatin nanoparticles, 10 th international conference and workshop on Biological Barriers, 16-21 February 2014, Saarland University, Germany.


15. Saeed Ahmad Khan, Marc Schneider, Gelatin nanoparticles as a potential nanocarrier for macromolecular drugs, DPhG annual conference 2013, drug delivery inspired by nature 9-11 Oct. 2013, Freiburg University, Germany.


16. Saeed Ahmad Khan, Marc Schneider, Hydrophilic nanoparticles for hydrophilic macromolecular drugs, CRS local chapter meeting, 21-22 Mar. 2013, Ludwigshafen, Germany.Clemens Tscheka, Saeed Ahmad Khan, Mohamed Tawfik, Eman Haimour, Marc Schneider, Novel filamentous Carrier Systems based on biodegradable Hydrogels, CRS local chapter meeting, 21-22 Mar. 2013, Ludwigshafen, Germany.


17. Kaul, G. and M. Amiji, Long-circulating poly (ethylene glycol)-modified gelatin nanoparticles for intracellular delivery. Pharmaceutical research, 2002. 19(7): p. 1061-1067.


18. Bigi, A., et al., Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials, 2001. 22(8): p. 763-768.


19. Clemens Tscheka, Eman Haimour, Saeed Ahmad Khan, Marc Schneider, Novel filamentous carrier systems for drug delivery to bio-films, 2 nd HIPS Symposium on Pharmaceutical sciences devoted to infection research, 28. June 2012, Saarland University, Germany.


20. Galindo-Rodriguez, S., et al., Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharmaceutical Research, 2004. 21(8): p. 1428-1439.


21. Janes, K.A., P. Calvo, and M.J. Alonso, Polysaccharide colloidal particles as delivery systems for macromolecules. Advanced Drug Delivery Reviews, 2001. 47: p. 83-97.


22. Kommareddy, S. and M. Amiji, Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione. Bioconjugate Chem, 2005. 16(6): p. 1423-1432.


23. Coester, C., et al., Preparation of avidin-labelled gelatin nanoparticles as carriers for biotinylated peptide nucleic acid (PNA). International Journal of Pharmaceutics, 2000. 196(2): p. 147-149.


24. Qazvini, N.T. and S. Zinatloo, Synthesis and characterization of gelatin nanoparticles using CDI/NHS as a non-toxic cross-linking system. Journal of Materials Science: Materials in Medicine, 2011. 22(1): p. 63-69.


25. Mohanty, B. and H.B. Bohidar, Systematic of Alcohol-Induced Simple Coacervation in Aqueous Gelatin Solutions Biomacromolecules, 2003. 4(4): p. 1080 -1086.


26. Gupta, A., Reena, and H.B. Bohidar, Free-energy landscape of alcohol driven coacervation transition in aqueous gelatin solutions. The Journal of Chemical Physics, 2006. 125(054904 ).


27. Bilati, U., E. Allémann, and E. Doelker, Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. European Journal of Pharmaceutical Sciences, 2005. 24(1): p. 67-75.


28. Hines, D.J. and D.L. Kaplan, Mechanisms of controlled release from silk fibroin films. Biomacromolecules, 2011. 12(3): p. 804-812.


29. Leo, E., R. Cameroni, and F. Forni, Dynamic dialysis for the drug release evaluation from doxorubicin-gelatin nanoparticle conjugates. International Journal of Pharmaceutics, 1999. 180(1): p. 23-30.


30. Lee, E.J., S.A. Khan, and K.-H. Lim, Gelatin Nanoparticle Preparation by Nanoprecipitation. Journal of biomaterials science. Polymer edition, 2010. 22(4-6): p. 753-771.