Thrombin Generation by Gentamicin

The present work examines how human coagulation is influenced by gentamicin (gentamicin×H2SO4), an often used aminoglycoside antibiotic in clinical practice. As a potent broad-spectrum antibiotic, gentamicin is frequently used in life-threatening, septic conditions, in which physiologic human coa...

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Bibliographic Details
Main Author: Albert, Dada Aishe
Contributors: Stief, T. (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2014
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1. Müller-Berghaus G (1999) Hämostaseologie : molekulare und zelluläre Mechanismen, Pathophysiologie und Klinik ; mit 127 Tab., Springer, Berlin:269-284

2. Pötzsch B, Gawaz MP (2010) Hämostaseologie [Grundlagen, Diagnostik, Therapie]; mit 163 Tabellen, Springer, Berlin, 2. Auflage:123-127

3. Robinson S, Zincuk A, Larsen UL, Ekstrøm C, Nybo M, Rasmussen B, Toft P (2013) A comparative study of varying doses of enoxaparin for thromboprophylaxis in critically ill patients: a double-blinded, randomised controlled trial. Crit Care 17:1-8

4. Wolberg AS, Campbell RA (2008) Thrombin generation, fibrin clot formation and hemostasis. Transfus Apher Sci 38:15-23

5. Semeraro N, Ammollo CT, Semeraro F, Colucci M (2012) Sepsis, thrombosis and organ dysfunction. Thromb Res 129:290-295

6. Mosesson MW (2007) Update on antithrombin I (fibrin). Thromb Haemost 98:105-108

7. Stief, TW (2009) Coagulation activation by lipopolysaccharides. Clin Appl Thromb Hemost 15:209-219

8. Newby B, Prevost D, Lotocka-Reysner H (2009) Assessment of gentamicin 7 mg/kg once daily for pediatric patients with febrile neutropenia: a pilot project. J Oncol Pharm Pract 15:211-216

9. Nakstad B, Haugen T, Skjønsberg OH, Lyberg T (1998) Expression of leukocyte integrins and tissue factor in mononuclear phagocytes. Eur Respir J 12:601-606

10. Stief, TW (2008) Innovative Tests of Plasmatic Hemostasis. LabMedicine, 39:225-227

11. Selimoglu E (2007) Aminoglycoside-induced ototoxicity. Curr Pharm Des 13:119-126

12. Smid M, Dielis AW, Spronk HM, Rumley A, van Oerle R, Woodward M, Ten Cate H, Lowe G (2013) Thrombin generation in the glasgow myocardial infarction study. PLoS One 8:1-6

13. Vogler EA, Siedlecki CA (2009) Contact activation of blood-plasma coagulation. Biomaterials 30:1857-1869

14. Pacifici GM (2009) Clinical pharmacokinetics of aminoglycosides in the neonate: a review. Eur J Clin Pharmacol 65:419-427

15. Aktories K, Forth W, Allgaier C (2009) Allgemeine und spezielle Pharmakologie und Toxikologie für Studenten der Medizin, Veterinärmedizin, Pharmazie, Chemie und Biologie sowie für Ärzte, Tierärzte und Apotheker ; mit 305 Tabellen. Elsevier, Urban & Fischer, München, 10. Auflage:818-823

16. Sha SH, Qiu JH, Schacht J (2006) Aspirin to prevent gentamicin-induced hearing loss. N Engl J Med 354:1856-1857

17. Altieri DC, Agbanyo FR, Plescia J, Ginsberg MH, Edgington TS, Plow EF (1990) A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). J Biol Chem 265:12119-12122

18. Rand MD, Lock JB, van't Veer C, Gaffney DP, Mann KG (1996) Blood clotting in minimally altered whole blood. Blood 88:3432-3445

19. Stypulkowska K, Blazewicz A, Fijalek Z, Sarna K (2010) Determination of Gentamicin Sulphate Composition and Related Substances in Pharmaceutical Preparations by LC with Charged Aerosol Detection. Chromatographia 72:1225-1229

20. Akbayram S, Dogan M, Akgun C, Peker E, Parlak M, Oner AF (2011) Disseminated intravascular coagulation in a case of brucellosis. Clin Appl Thromb Hemost, United States, 17:E10-12

21. Aly EE, Sivasubramaniam SK, Bhatti TH, Sanaka R (2009) Endotoxin-like reaction following once-daily gentamicin. Acta Anaesthesiol Scand 53:830-832

22. Stief TW (2009) Enhancement of Thrombin Generation by Normal Thrombocytes. Hemostasis Laboratory 2:65-72

23. Simon D, Rao N, Xu H, Wei Y, Majdic O, Ronne E, Kobzik L, Chapman H (1996) Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells., Blood 88:3185-3194

24. Nagai J, Takano M (2004) Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokinet 19:159-170

25. Stief, TW (2008) The laboratory diagnosis of the pre-phase of pathologic disseminated intravascular coagulation. Hemostasis Laboratory, 1:3-19

26. Siller-Matula JM, Schwameis M, Blann A, Mannhalter C, Jilma B (2011) Thrombin as a multi-functional enzyme. Focus on in vitro and in vivo effects. Thromb Haemost 106:1020-1033

27. Stief, TW, Klingmüller, V, Müller-Stüler, EM (2011) Thrombin generation by diagnostic ultrasound. Hemostasis Laboratory, 4:335-363

28. Naldini A, Aarden L, Pucci A, Bernini C, Carraro F (2003) Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses. Br J Pharmacol 140:980-986

29. Sakurai S, Shiojima I, Tanigawa T, Nakahara K (1997) Aminoglycosides prevent and dissociate the aggregation of platelets in patients with EDTA-dependent pseudothrombocytopenia. Br J Haematol 99:817-823

30. Wada H, Hatada T, Okamoto K, Uchiyama T, Kawasugi K, Mayumi T, Gando S, Kushimoto S, Seki Y, Madoiwa S, Okamura T, Toh CH, subcommittee JSoTHD (2010) Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC. Am J Hematol 85:691-694

31. Van Montfoort ML, Meijers JC (2013) Anticoagulation beyond direct thrombin and factor Xa inhibitors: indications for targeting the intrinsic pathway? Thromb Haemost 110:223-232

32. Simon DI, Ezratty AM, Francis SA, Rennke H, Loscalzo J (1993) Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway. Blood 82:2414-2422

33. Perez RL, Roman J (1995) Fibrin enhances the expression of IL-1 beta by human peripheral blood mononuclear cells. Implications in pulmonary inflammation. J Immunol 154:1879-1887

34. Undas A, Brummel-Ziedins KE, Mann KG (2007) Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions. Blood 109:2285-2292

35. Soifer SJ, Peters KG, O'Keefe J, Coughlin SR (1994) Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol 144:60-69

36. Rourke T (2007) Aminoglycoside ototoxicity: How practical is this genetic screening test? BMJ 335:952

37. Renné T, Pozgajová M, Grüner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B (2005) Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med 202:271-281

38. Roth SM, Williams SM, Jiang L, Menon KS, Jeka JJ (2008) Susceptibility genes for gentamicin-induced vestibular dysfunction. J Vestib Res 18:59-68

39. Ward K, Theiler RN (2008) Once-daily dosing of gentamicin in obstetrics and gynecology. Clin Obstet Gynecol 51:498-506

40. Wright SD, Weitz JI, Huang AJ, Levin SM, Silverstein SC, Loike JD (1988) Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc Natl Acad Sci U S A 85:7734-7738

41. Pierfranceschi MG, Imberti D, Orlando S, Vallisa D, Michieletti E (2011) Effectiveness of recombinant activated factor VII in haemorragic cancer-related disseminated intravascular coagulation: a case report. Blood Transfus 9:336-338

42. Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR (2011) Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Blood 118:5302-5311

43. Spronk HM, van der Voort D, Ten Cate H (2004) Blood coagulation and the risk of atherothrombosis: a complex relationship. Thromb J 2:1-10

44. Puetz J (2010) Optimal use of recombinant factor VIIa in the control of bleeding episodes in hemophilic patients. Drug Des Devel Ther 4:127-137

45. Santos LH, Araujo AN, Reis B, Montenegro MC (2010) Development of a multicommutated flow system with chemiluminometric detection for quantification of gentamicin in pharmaceuticals. J Autom Methods Manag Chem 2010:1-7