Contributions to the Asymmetric Synthesis of Octahedral Ruthenium(II) Complexes and to Bioactive Hexacoordinate Silicon Complexes

This thesis mainly includes two parts: one is about the asymmetric synthesis of octahedral ruthenium complexes, and the other one is about the synthesis and investigation of the biological activities of octahedral silicon complexes. In the first part of this thesis, we started with a straightforwar...

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Bibliographic Details
Main Author: Fu, Chen
Contributors: Meggers, Eric (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2014
Chemie
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Summary:This thesis mainly includes two parts: one is about the asymmetric synthesis of octahedral ruthenium complexes, and the other one is about the synthesis and investigation of the biological activities of octahedral silicon complexes. In the first part of this thesis, we started with a straightforward and economical method for the asymmetric synthesis of mononuclear ruthenium(II) complexes [Ru(pp)(pp’)(pp’’)](PF6)2 (pp = polypyridyl ligands) by using the readily available racemic starting material [Ru(pp)(pp’)Cl2] together with the natural amino acid L-proline. Next, we initially studied the asymmetric synthesis of dinuclear octahedral ruthenium(II) complexes, and synthesized an enantiomerically enriched dinuclear ruthenium complex for the first time. In the second part of this thesis, we developed the syntheses of hydrolytically stable octahedral silicon complexes, such as silicon arenediolate complexes, silicon arenediaminate complexes, enantiopure silicon BINOLate complexes, and silicon-ruthenium sandwich complexes. Furthermore, we investigated the biological activities of the octahedral silicon complexes and found that the silicon arenediolate complexes could be used as efficient DNA intercalators, while the bulky silicon-ruthenium sandwich complexes could detect mismatched DNA and serve as insertors.
DOI:https://doi.org/10.17192/z2014.0243