Neue Gentargeting-Strategien auf Basis der RNA interference RNAi

RNA Interferenz ist ein natürlicher Prozess in eukaryoten Zellen, der zur spezifischen Herunterregulation der Genexpression (Gen-Silencing) führt. Der Mechanismus der RNAi wird durch 21 - 23 nt lange doppelsträngige RNA-Moleküle (siRNA) vermittelt, welche sequenzspezifisch den Abbau und die Degradat...

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Bibliographic Details
Main Author: Werth, Stephanie
Contributors: Aigner, Achim (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2013
Pharmakologisches Institut
Online Access:PDF Full Text
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1. Höbel, S., Aigner, A. " Polyethylenimine (PEI)/siRNA-mediated gene knockdown in vitro and in vivo " Methods Mol Biol. 2010;623:283-97.

2. Senger, D. R. " Retrospetive: Vascular Endothelial Growth Factor: Much More than an Angiogenesis Factor " Molecular Biology of the Cell, Vol. 21, 377–379, February 1, 2010 [Singha et al. (2011)]

3. Tol, J., Punt, C. J. " Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review " Clin Ther. 2010 Mar;32(3):437-53 [Urban-Klein et al. (2005)]

4. Jiang, H. L., Kim, T. H., Kim, Y. K., Park, I. Y., Cho, M. H., Cho, C. S. " Efficient gene delivery using chitosan-polyethylenimine hybrid systems " Biomed Mater. 2008 Jun;3(2):025013.

5. Seisenberger, G., Ried, M. U., Endress, T., Buning, H., Hallek, M. and Brauchle, C. (2001) " Real-time single-molecule imaging of the infection pathway of an adeno-associated virus " Science 294(5548): 1929-32 [Schröder et al. (2009)]

6. Roy, H., Bhardwaj, S., Ylä-Herttuala, S. " Biology of vascular endothelial growth factors " FEBS Letters 580 (2006) 2879-2887 [Seisenberger et al. (2001)]

7. Kabanov, V. A., Kabanov A. V. " Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects " Adv Drug Deliv Rev. 1998 Mar 2;30(1-3):49-60.

8. Suh, J., Paik, H. J., Hwang, B. K. " Ionization of Poly(ethylenimine) and Poly(allylamine) at various pH′s " Bioorg. Chem. 22 (1994) 318-327 [Talsma et al. (1997)]

9. Rols, M. P. " Mechanism by which electroporation mediates DNA migration and entry into cells and targeted tissues " Methods Mol Biol. 2008;423:19-33 [Roy et al. (2006)]

10. of frozen complexes as fully active reagents in siRNA-mediated gene targeting and DNA delivery " Eur J Pharm Biopharm. 2008 Sep;70(1):29-41.

11. Imai, S., Kaksonen, M., Raulo, E., Kinnunen, T., Fages, C., Meng, X., Lakso, M., Rauvala, H. " Osteoblast Recruitment and Bone Formation Enhanced by cell Matrixassociated Heparin-binding Growth-associated Molecule (HB-GAM). J Cell Biol. 143: 1113-1128 (1998) [Jäger et al. (2012)]

12. Schulte, A., and Wellstein, A. (1997) " Pleiotrophin and related molecules " Bicknell, R., Lewis, C. M. and Ferrara, N. (eds.), Tumor angiogenesis, pp. 273-

13. Singha, K., Namgung, R., Kim, W. J. " Polymers in Small-Interfering RNA Delivery " Nucleic Acid Ther. 2011 June; 21(3): 133–147 [Souttou et al. (1998)]

14. Souttou, B., Juhl, H., Hackenbruck, J., Röckseisen, M., Klomp, H. J., Raulais, D., Vigny, M., Wellstein, A. " Relationship between serum concentrations of the growth factor pleiotrophin and pleiotrophin-positive tumors " J Natl Cancer Inst. 1998 Oct 7;90(19):1468-73.

15. Robert, N. J., Diéras, V., Glaspy, J., Brufsky, A. M., Bondarenko, I., Lipatov, O. N., Perez, E. A., Yardley, D. A., Chan, S. Y., Zhou, X., Phan, S. C., O'Shaughnessy, J. " RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer " J Clin Oncol. 2011 Apr 1;29(10):1252-60 [Rols (2008)]

16. Urban-Klein, B., Werth, S., Czubayko, F., Aigner, A. (2005) " RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)- complexed siRNA in vivo. " Gene Therapy 12(5): 461-466 [Vandoorne et al. (2010)]

17. Schröder FH, Hugosson J, Roobol MJ et al. (2009) Screening and prostate- cancer mortality in a randomized European study. N Engl J Med. 2009 Mar 26; 360(13): 1320–8

18. Talsma, H., Cherng, J., Lehrmann, H., Kursa, M., Ogris, M., Hennink, W. E., Cotten, M., Wagner, E. " Stabilization of gene delivery systems by freeze-drying " Int J Pharm. 1997 Nov 28;157(2):233-238 [Tang and Szoka (1997)]

19. Tang, M. X., Szoka, F. C. " The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes " Gene Ther. 1997 Aug;4(8):823-32 [Tol et al. (2010)]

20. Kajdaniuk, D., Marek, B., Forty, W., Kos-Kudła, B. " Vascular endothelial growth factor (VEGF) -part 1: in physiology and pathophysiology " Endokrynol Pol. 2011; 62(5):444-55.

21. Beiträge zur Gesundheitsberichterstattung des Bundes " Verbreitung von Krebserkrankungen in Deutschland, Entwicklung der Prävalenzen zwischen 1990 und 2010 " Eine Veröffentlichung des Zentrums für Krebsregisterdaten am RKI, Robert Koch-Institut, Berlin 2010, Bibliografische Information Der Deutschen Bibliothek (Die Deutsche Bibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie) [Robert et al. (2011)]

22. Jäger, M., Schubert, S., Ochrimenko, S., Fischer, D., Schubert, U. S. " Branched and linear poly(ethylene imine)-based conjugates: synthetic modification, characterization, and application " Chem Soc Rev. 2012 Jul 7;41(13):4755-67 [Jiang et al. (2008)]

23. Stoica, G. E., Kuo, A., Aigner, A., Sunitha, I., Souttou, B., Malerczyk, C., Caughey, D. J., Wen, D., Karavanov, A., Riegel, A. T., Wellstein, A. " Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin " J Biol Chem 2001, 276:16772-16779

24. Ribatti, D., Vacca, A. " The role of microenvironment in tumor angiogenesis " Genes Nutr. 2008 Apr; 3(1):29-34

25. Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007 Jun 18;96(12):1788-95 [Kambhampati et al. (2005)]

26. Remy, J. S., Abdallah, B., Zanta M. A., et al. " Gene transfer with lipospermines and polyethylenimines " Advanced Drug Delivery Reviews 30 (1998) 85-95 [Ribatti et al. (2008)]

27. Honoré, I., Grosse, S., Frison, N., Favatier, F., Monsigny, M., Fajac, I. " Transcription of plasmid DNA: influence of plasmid DNA/polyethylenimine complex formation " J Control Release. 2005 Oct 20;107(3):537-46 [Imai et al. (1998)]

28. Kambhampati, S., Ray, G., Sengupta, K., Reddy, V. P., Banerjee, S. K., Van Veldhuizen, P. J. " Growth factors involved in prostate carcinogenesis " Front Biosci. 2005 May 1;10:1355-67 [Remy et al. (1998)]