Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

Interaction dynamics between heterotrimeric G-proteins and type V adenylyl cyclase determine sensitivity of effector regulation

The signalling pathway from G-protein-coupled receptors to the second messenger cAMP is present in virtually all cells and of major physiological and pathophysiological importance. The membrane-spanning receptors can easily be targeted by pharmaceutical compounds and therapies to treat diseases like...

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Détails bibliographiques
Auteur principal: Milde, Markus
Autres auteurs: Bünemann, Moritz (Prof. Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2013
Sujets:
Dynamik
Adenylylzyklase
cAMP
interaction
G-protein
adenylyl cyclase
Interaktion
Fluoreszenz-Resonanz-Energie-Transfer
G-Protein
Medizin
FRET
Medical sciences Medicine
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