Quantifizierung von Polymorphismen im Tumor-Nekrose-Alpha Gen und im Interleukin-10 Gen bei Patienten mit dilatativer Kardiomyopathie

Bei der Pathogenese der DCM sind diverse Zytokine beteiligt. In diesem Kontext spielen insbesondere das pro-inflammatorische TNF-α und das anti-inflammatorische IL-10 eine wichtige Rolle. In der Literatur wurde über einen Zusammenhang des G/A-SNP am Genlocus -308 im TNF-α Gen und des G/A-SNP am Genl...

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Bibliographic Details
Main Author: Pietz, Daniela
Contributors: Misch, Bernhard (Prof. Dr. ) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2013
Innere Medizin
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1. Sivasubramanian N, Coker ML, Kurrelmeyer KM, MacLellan WR, DeMayo FJ, Spinale FG, Mann DL. Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor. Circulation (2001) 104:826-831


2. Staudt A; Landsberger M; Staudt Y; Felix SB: Die Rolle der Zytokine bei der Herzin- suffizienz. Herz (2002) 27: 691-698


3. Ristić AD, Pankuweit S, Maksimović R, Moosdorf R, Maisch B: Pericardial cytokines in neoplastic, autoreactive, and viral pericarditis. Heart Fail Rev. 2012


4. Clark DN, Markham JL, Sloan CS, Poole BD: Cytokine inhibition as a strategy for treating systemic lupus erythematosus. Clin Immunol (2012) 1521-6616


5. Stumpf C, Seybold K, Petzi S, Wasmeier G, Raaz D, Yilmaz A, Anger T, Daniel WG, Garlichs CD: Interleukin-10 improves left ventricular function in rats with heart fail- ure subsequent tomyocardial infarction. Eur J Heart Fail (2008) 10(8):733-9


6. Sainz J, Hassan L, Perez E, Romero A, Moratalla A, López-Fernández E, Oyonarte S, Jurado M: Interleukin-10 promotor polymorphism as risk factor to develop invasive pulmonary aspergillosis. Immunol Lett (2007) 109(1):76-82


7. Zhang D, Li J, Jiang ZW, Yu B, Tang X: Association of two polymorphisms of tumor necrosis factor gene with acute severe pancreatitis. J Surg Res (2003) 112(2):138-143


8. Shaw T, Elliot P, McKenna WJ: Dilated cardiomyopathy: a genetical heterogeneous disease. Lancet (2002) 360:654-655


9. Weber-Nordt RM, Riley JK, Greenlund AC, Moore KW, Darnell JE, Schreiber RD: Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J Biol Chem (1996) 271(44):27954- 27961


10. Nagai R, Komuro I: gp130 plays a critical role in pressure overload-induced cardiac hypertrophy. J Biol Chem (2001) 276(25):23115-23119


11. van der Poll T, Jansen J, Levi M, ten Cate H, ten Cate JW, van Deventer SJ: Regula- tion of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. J Exp Med (1994) 180(5):1985-1988


12. Chatterjee R, Batra J, Kumar A, Mabalirajan U, Nahid S, Niphadkar PV, Ghosh B: In- terleukin-10-promotor-polymorhisms and atopic asthma in North Indians. Clin Exp Al- lergy (2005) 35(7):914-919


13. Rudwaleit M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A, Sieper J, Braun J: Low T cell production of TNF-alpha and IFN-gamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF -308 gene polymorphism. Ann Rheum (2001) 60:36-42


14. Ridker PM, Rifai N, Pfeffer M, Sacks F, Lepage S, Braunwald E: Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation (2000) 101:2149-2153


15. Schwarz F, Mall G, Zebe H, Schmitzer E, Manthey J, Scheurlen H, Kubler W: Deter- minants of survival in patients with congestive cardiomyopathy: quantitative morpho- logic findings and left ventricular hemodynamics. Circulation (1984) 70: 923-928


16. Cordeiro CA, Moreira PR, Andrade MS, Dutra WO, Campos WR, Oréfice F, Teixeira AL: Interleukin-10 gene polymorphism (-1082G/A) is associated with toxoplasmic reti- nochoroiditis. Invest Ophthalmol Vis Sci (2008) 49(5):1979-1982


17. Zhou M, Ding L, Peng H, Wang B, Huang F, Xu WD, Li JH, Ye XR, Pan HF, Ye DQ: Association of the interleukin-10 gene polymorphism (-1082A/G) with systemic lupus erythematosus: a meta-analysis. Lupus 2012 Nov 28


18. Sasaki M, Nakajima K, Perinchery G, Fujino T, Oh BR, Fujimoto S, Dahiya R: Fre- quent genotype changes at -308 of the human tumor necrosis factor-alpha promoter re- gion in human uterine endometrial cancer. Oncol Rep (2000) 7(2):369-373


19. Sharma R, Coats AJ, Anker SD: The role of inflammatory mediators in chronic heart failure: cytokines, nitric oxide, and endothelin-1. Int J Cardiol (2000) 72(2):175-186


20. Grobbee DE: The epidemiology of heart failure. Eur Heart J (1997) 18: 208-225


21. Westendorp RG, Langermans JA, Huizinga TW, Elouali AH, Verweij CL, Boomsma DI, Vandenbroucke JP: Genetic influence on cytokine production and fatal meningo- coccal disease. Lancet (1997) 349(9046):170-173


22. Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW: An allel- ic polymorphism within the human tumor necrosis factor alpha promoter region is 8. Literaturverzeichnis 112 strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med (1993)177(2):557- 560


23. Yamaoka M, Yamaguchi S, Okuyama M, Tomoike H: Anti-inflammatory cytokine pro- file in human heart failure: behavior of interleukin-10 in association with tumor necrosis factor-alpha. Jpn Circ J (1999) 63(12):951-956


24. Ruppert V, Maisch B: Molecular signatures and the study of gene expression profiles in inflammatory heart diseases. Herz (2012) 37(6):619-626


25. Yamada K, Yuan X, Ishiyama S, Ichikawa F, Kohno S, Shoji S, Hayashi H, Nonaka K: Identification of a single nucleotide insertion polymorphism in the upstream region of 8. Literaturverzeichnis 113 the insulin promoter factor-1 gene: an association study with diabetes mellitus. Diabeto- logia (1998) 41:603-605


26. Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, Levine GN, Narula J, Starling RC, Towbin J, Virmani R; American Heart Association; American College of Cardiology; European Society of Cardiology: The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the


27. Spiroska V, Kedev S, Antov S, Trajkov D, Petlichkovski A, Hristomanova S, Djulejic E, Paneva M, Senev A, Spiroski M: Association between 22 cytokine gene polymor- 8. Literaturverzeichnis 107 phisms and dilated cardiomyopathy in Macedonian patients. Kardiol Pol. (2009) 67


28. Seta Y, Shan K, Bozkurt B, Oral H, Mann DL: Basic mechanisms in heart failure: the cytokine hypothesis. J Card Fail (1996) 2:243-249


29. Yokoyama T, Vaca L, Rossen RD, Durante W, Hazarika P, Mann DL: Cellular basis for the negative inotropic effects of tumor necrosis factor-a in the adult mammalian heart. J Clin Invest (1993) 92:2303-2312


30. Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zavodny PJ, Narula SK: Crystal structure of a complex between interferon-and its soluble high affinity re- ceptor. Nature (1995) 376:230-235


31. van Deuren M, Dofferhoff AS, van der Meer JW: Cytocines and the response to infec- tion. J Pathol (1992) 168(4):349-356


32. Abbildung 4: Darstellung der amplifizierten DNA-Sequenz von TNF-α mit einer Guanin-bzw. Adeninbase an Position -308 und den jeweiligen Schnittstellen des


33. Stumpf C, Lehner C, Yilmaz A, Daniel WG, Garlichs CD: Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failure. Clin Sci (2003) 105:45-50


34. Watanabe J, Hayashi S-I, Kawajiri K: Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5' flanking region. J Biochem (1994) 116: 321-326


35. Stein B, Frank P, Schmitz W, Scholz H, Thoenes M: Endotoxin and cytokines induce direct cardiodepressive effects in mammalian cardiomyocytes via induction of nitric oxide synthase. J Mol Cell Cardiol (1996) 28:1631-1639


36. Codd MB, Sugrue DD, Gersh BJ, Melton LJ: Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. Circulation (1989) 80: 564-572


37. Spits H, de Waal Malefyt R: Functional characterization of human IL-10. Int Arch Al- lergy Immunol (1992) 99(1):8-15


38. Wilson AG, di Giovine FS, Duff GW: Genetics of tumour necrosis factor-alpha in auto- immune, infectious, and neoplastic diseases. J Inflamm (1995) 45(1):1-12


39. Waldmüller S, Erdmann J, Binner P, Gelbrich G, Pankuweit S, Geier C, Timmermann B, Harmeza J, Perrot A, Scheer S, Wachter R, Schulze-Waltrup N, Dermintzoglou A, Schönberger J, Zeh W, Jrmann B, Brodherr T, Börgel J, Farr M, Miltring H, Blanken- feldt W, Reinhardt R, Özcelik C, Osterziel KJ, Loeffler M, Maisch B, Regitz-Zagrosek V, Schunkert H, Schefffold T, Germen Competence Network Heart Failure: Novel cor- relations between the genotype and the phenotype of hypertrophic and dilated cardio- myopathy: results from the German Competence Network Heart Failure. Eur J Heart Fail (2011) 13 (11):1185-1192


40. IL-10 genotype with steroid dependency. Am J Gastroenterol (2006) 101(5):1039-1047


41. Satoh M, Nakamura M, Tamura G, Makita S, Segawa I, Tashiro A, Satodate R, Hiramo- ri K.: Inducible nitric oxide synthase and tumor necrosis factor-alpha in myocardium in human dilated cardiomyopathy. J Am Coll Cardiol (1997) 29:716-724


42. Zhu H, Lei X, Liu Q, Wang Y: Interleukin-10-1082A/G polymorphism and inflammato- ry bowel disease susceptibility: A meta-analysis based on 17,585 subjects.. (2013) 61(1):146-153


43. Riley JK, Takeda K, Akira S, Schreiber RD: Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti- inflammatory action. J Biol Chem (1999) 274(23):16513-16521


44. Schwabe RF, Brenner DA: Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 290(4):583-589


45. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken AH, Meng X: Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardi- um. Shock (2002)17:114-119


46. Xie CJ, Chen L, Tong FL, Xiao LM, Zhang JC: Meta analysis of association between TNF-α-308 polymorphism and periodontitis in Chinese Han population. Shanghai Kou Qiang Yi Xue (2012) 21(4):447-450


47. Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell (1990) 61:361-370


48. Torre-Amione G, Kapadia S, Benedict C, Oral H, Young JB, Mann DL: Proinflammato- rycytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol (1996b) 27: 1201-1206


49. Sliwa K, Skudicky D, Candy G, Wisenbaugh T, Sareli P: Randomized investigation of effects of pentoxifylline on left ventricular performance in idiopathic dilated cardiomy- opathy. Lancet (1998) 351:1091–1093


50. Wojnicz R, Nowalany-Kozielska E, Wojciechowska C, Glanowska G, Wilczewski P, Niklewski T, Zembala M, Polonski L, Rozek MM, Wodniecki J: Randomized, placebo- controlled study for immunosuppressive treatment of inflamma tory dilated car dio myo pathy: two-year fol low-up re sults. Circulation (2001) 104: 39–45


51. WHO/ISFC Task Force: Report of the WHO / ISFC task force on the definition and classification of cardiomyopathie. Br Heart J (1980) 44: 672-674


52. Wilson AG, di Giovine FS, Blakemore AI, Duff GW: Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet (1992) 1(5):353


53. American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation (2007) 116(19):2216-2233


54. Vassalli P: The patholphysiologie of tumor necrosis factors. Annu rev immunol (1992) 10: 411-452


55. Chen G, Goeddel DV: TNF-R1 signaling: A beautiful pathway. Science (2002) 296:1634-1635


56. Sariban E, Imamura K, Leubbers R, Kufe D: Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes. J Clin Invest (1988) 81: 1506-1510


57. Satoh M, Nakamura M, Saitoh H, Satoh H, Maesawa C, Segawa I, Tashiro A, Hiramori K: Tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in human dilated cardiomyopathy. Circulation (1999) 99:3260-3265


58. Yokoyama T, Nakano M, Bednarczyk JL, McIntyre BW, Entman M, Mann DL. Tumor necrosis factor-alpha provokes a hypertrophic growth response in adult cardiac myo- cytes. Circulation (1997) 95:12471252


59. Suda T, Murray R, Fischer M, Yokota T, Zlotnik A: Tumor necrosis factor-α and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2. J lmmunol (1990) 144: 1783-1787


60. Tracey KJ, Cerami A: Tumor necrosis factor: a pleiotropic cytokine and therapeutic target. Annu Rev Med (1994) 45:491-503


61. Ceconi C, Curello S, Bachetti T, Corti A, Ferrari R: Tumor necrosis factor in congestive heart failure: a mechanism of disease for the new millennium? Prog Cardiovasc Dis (1998) 41(1):25-30


62. Sung S-SJ, Walters JA, Hudson J, Gimble JM: Tumor necrosis factor-α mRNA accu- mulation in myelomonocytic cell lines. J Immunol (1991) 147: 2047-2054


63. Wajant H, Pfizenmaier K, Scheurich P: Tumor necrosis factor signaling. Cell Death Differ (2003) 10(1):45-65


64. Von Haehling S, Jankowska EA, Anker SD: Tumour necrosis factor-alpha and the fail- ing heart-pathophysiology and therapeutic implications. Basic Res Cardiol (2004) 99:18-28


65. Wilson AG, Gordon C, di Giovine FS, de Vries N, van de Putte LBA, Emery P, Duff GW: A genetic association between systemic lupus erythamatosus and tumor necrosis factor alpha. Eur J Immunol (1994) 24:191-195


66. Wehinger J, Gouilleux F, Groner B, Finke J, Mertelsmann R, Weber-Nordt RM: IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett (1996) 394(3):365-370


67. Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV.: An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet (1997) 24(1):1-8


68. Uglialoro AM, Turbay D, Pesavento PA, McKenzie FE, Delgado JC, Gribben JG, Harti D, Edmond JY, Goldfeld AE: Identification of three new single nucleotide polymor- phisms in the human tumor necrosis factor-alpha gene promoter. Tissue Antigens (1998) 52:359-367


69. Wang Y, Zhou Y, Meng L, Lu X, Ou N, Li X: Inflammatory mediators in Chinese pa- tients with congestive heart failure. J Clin Pharmacol (2009) 49(5):591-599


70. Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cos- man D, Goodwin RG. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science (1990) 248:1019-1023


71. Smith RA, Baglioni C: The active form of tumor necrosis factor is a trimer. J Biol Chem (1987) 262 (15): 6951-6954


72. Tagore A, Gonsalkorale WM, Pravica V, Hajeer AH, McMahon R, Whorwell PJ, Sinnott PJ, Hutchinson IV: Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens (1999) 54: 386-390


73. Schönberger J, Seidman CE: Many roads lead to a broken heart: the genetics of dilated cardiomyopathy. Am J Hum Genet (2001) 69: 249 – 260


74. Wang J M, Walter S, Mantovani A: Re-evaluation of the chemotactic activity of tumour necrosis factor for monocytes. Immunology (1990) 71:364-367


75. William LM, Ricchetti G, Sarma U, Smallie T, Foxwell BM: Interleukin-10 suppression of myeloid cell activation--a continuing puzzle. Immunology (2004) 113(3):281-292


76. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW: Effects of a poly- morphism in the human tumor necrosis factor a promoter on transcriptional activation.


77. Towbin JA, Bowles NE: The failing heart. Nature (2002) 415: 227-233


78. Schmid DS, Tite JP, Ruddle NH: DNA fragmentation: manifestation of target cell de- struction mediated by cytotoxic T-cell clones and cell-free lymphotoxin-containing su- pernatant. Proc Natl Acad Sci USA (1986) 83: 1881-1887


79. Schmaltz AA: Dilated cardiomyopathy in childhood. Z Kardiol (2001) 90: 263-268


80. Vacchelli E, Galluzzi L, Eggermont A, Galon J, Tartour E, Zitvogel L, Kroemer G: Tri- al Watch: Immunostimulatory cytokines. Oncoimmunology (2012) 1(4):493-506


81. Rousset F, Garcia E, Defrance T, Péronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J: Interleukin 10 is a potent growth and differentiation factor for acti- vated human B lymphocytes. Proc Natl Acad Sci USA (1992) 89(5):1890-1893


82. Suda T, O'Garra A, MacNeil I, Fischer M, Bond MW, Zlotnik A: Identification of a novel thymocyte growth-promoting factor derived from Bcell lymphomas. Cell Immu- nol (1990) 129:228


83. Seidman JG, Seidman C: The genetic basis for cardiomyopathy: from mutation identifi- cation to mechanistic paradigms. Cell (2001) 104: 557-567


84. Wu LY, Zhou Y, Qin C, Hu BL: The effect of TNF-alpha, FcγR and CD1 polymor- phisms on Guillain-Barré syndrome risk: evidences from a meta-analysis. J Neuroim- munol (2012) 243(1-2):18-24


85. Wykretowicz A, Furmaniuk J, Smielecki J, Deskur-Smielecka E, Szczepanik A, Banaszak A, Wysocki H: The oxygen stress index and levels of circulating interleukin- 10 and interleukin-6 in patients with chronic heart failure. Int J Cardiol (2004) 94:283- 287


86. Von Haehling S, Schefold JC, Lainscak M, Doehner W, Anker SD: Inflammatory bi- omarkers in heart failure revisited: much more than innocent bystanders. Heart Fail Clin. (2009) 5(4):549-560


87. Shukla RK, Kant S, Bhattacharya S, Mittal B: Association of cytokine gene polymor- phisms in patients with chronic obstructive pulmonary disease. Oman Med J (2012) 27(4):285-290