Regulation of motility and polarity in Myxococcus xanthus

M. xanthus cells possess two independent motility systems: the adventurous (A) system and the social (S) system. S-motility depends on the extension and retraction of Type-4-pili, whereas A-motility is mediated via focal adhesion complexes that incorporate a MotAB-like motor. The rod-shaped M. xanth...

Full description

Saved in:
Bibliographic Details
Main Author: Keilberg, Daniela
Contributors: Søgaard-Andersen, Lotte (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2013
Biologie
Subjects:
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!

1. Punta M et al. (2012) The Pfam protein families database. Nucleic Acids Res 40:D290-301


2. Kirkpatrick CL, Viollier PH (2011) Poles apart: prokaryotic polar organelles and their spatial regulation. Cold Spring Harb Perspect Biol 3


3. Huitema E, Pritchard S, Matteson D, Radhakrishnan SK, Viollier PH (2006) Bacterial birth scar proteins mark future flagellum assembly site. Cell 124:1025-1037


4. Blackhart BD, Zusman DR (1985a) Cloning and complementation analysis of the "Frizzy" genes of Myxococcus xanthus. Mol. Gen. Genet. 198:243- 254


5. Blair DF, Berg HC (1990) The MotA protein of E. coli is a proton-conducting component of the flagellar motor. Cell 60:439-449


6. Lam H, Schofield WB, Jacobs-Wagner C (2006) A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell. Cell 124:1011-1023


7. Leonardy S, Bulyha I, Sogaard-Andersen L (2008) Reversing cells and oscillating motility proteins. Mol Biosyst 4:1009-1014


8. Youderian P, Burke N, White DJ, Hartzell PL (2003) Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner. Mol Microbiol 49:555-570


9. Kim SK, Kaiser D (1990) Cell motility is required for the transmission of C- factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes & Dev. 4:896-904


10. Wu SS, Kaiser D (1995) Genetic and functional evidence that Type IV pili are required for social gliding motility in Myxococcus xanthus. Mol Microbiol 18:547-558


11. Bustamante VH, Martinez-Flores I, Vlamakis HC, Zusman DR (2004) Analysis of the Frz signal transduction system of Myxococcus xanthus shows the importance of the conserved C-terminal region of the cytoplasmic chemoreceptor FrzCD in sensing signals. Mol. Microbiol. 53:1501-1513


12. Yu R, Kaiser D (2007) Gliding motility and polarized slime secretion. Mol Microbiol 63:454-467


13. Wennerberg K, Rossman KL, Der CJ (2005) The Ras superfamily at a glance. J Cell Sci 118:843-846


14. Mattick JS (2002) Type IV pili and twitching motility. Ann. Rev. Microbiol. 56:289-314


15. Kortholt A, van Haastert PJ (2008) Highlighting the role of Ras and Rap during Dictyostelium chemotaxis. Cell Signal 20:1415-1422


16. Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129:865-877


17. Shi X, Wegener-Feldbrugge S, Huntley S, Hamann N, Hedderich R, Sogaard- Andersen L (2008) Bioinformatics and experimental analysis of proteins of two-component systems in Myxococcus xanthus. J Bacteriol 190:613- 624


18. Zhang Y, Franco M, Ducret A, Mignot T (2010) A bacterial Ras-like small GTP- binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility. PLoS Biol 8:e1000430


19. Mauriello EM, Nan B, Zusman DR (2009) AglZ regulates adventurous (A-) motility in Myxococcus xanthus through its interaction with the cytoplasmic receptor, FrzCD. Mol Microbiol 72:964-977


20. Herzog A., Voss , Keilberg D., Hot E., Søgaard-Andersen L., Garbe C., Kostina E. (2012) A stategy for identifying fluorescence intensity profiles of single rod- shaped cells. Journal of Bioinformatics and Computational Biology Online Ready 1250024


21. Romantsov T, Helbig S, Culham DE, Gill C, Stalker L, Wood JM (2007) Cardiolipin promotes polar localization of osmosensory transporter ProP in Escherichia coli. Mol Microbiol 64:1455-1465


22. Keilberg D (2009) Cis-and trans-acting determinants of the response regulator RomR in M. xanthus, Diploma thesis


23. Mignot T, Shaevitz JW, Hartzell PL, Zusman DR (2007) Evidence that focal adhesion complexes power bacterial gliding motility. Science 315:853- 856


24. McBride MJ, Weinberg RA, Zusman DR (1989) "Frizzy" aggregation genes of the gliding bacterium Myxococcus xanthus show sequence similarities to the chemotaxis genes of enteric bacteria. Proc. Natl. Acad. Sci. U S A 86:424-428


25. Blackhart BD, Zusman DR (1985b) "Frizzy" genes of Myxococcus xanthus are involved in control of frequency of reversal of gliding motility. Proc. Natl. Acad. Sci. U S A 82:8771-8774


26. Sun M, Wartel M, Cascales E, Shaevitz JW, Mignot T (2011) From the Cover: Motor-driven intracellular transport powers bacterial gliding motility. Proc Natl Acad Sci U S A 108:7559-7564


27. Hodgkin J, Kaiser D (1979) Genetics of Gliding Motility in Myxococcus xanthus (Myxobacterales): Two gene systems control movement. Mol. Gen.


28. Bulyha I, Hot E, Huntley S, Sogaard-Andersen L (2011) GTPases in bacterial cell polarity and signalling. Curr Opin Microbiol 14:726-733


29. Morano KA, Thiele DJ (1999) Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals. Gene Expr 7:271-282


30. Trudeau KG, Ward MJ, Zusman DR (1996) Identification and characterization of FrzZ, a novel response regulator necessary for swarming and fruiting- body formation in Myxococcus xanthus. Mol. Microbiol. 20:645-655


31. Mechanistic insights into bacterial polarity from structural analysis of the Ras- like G protein MglA and its cognate GAP MglB. EMBO J. 30, 4185-4197.


32. Nan B, Chen J, Neu JC, Berry RM, Oster G, Zusman DR (2011) Myxobacteria gliding motility requires cytoskeleton rotation powered by proton motive force. Proc Natl Acad Sci U S A Nan B, Mauriello EM, Sun IH, Wong A, Zusman DR (2010) A multi-protein complex from Myxococcus xanthus required for bacterial gliding motility. Mol Microbiol 76:1539-1554


33. Nudleman E, Wall D, Kaiser D (2006) Polar assembly of the type IV pilus secretin in Myxococcus xanthus. Mol Microbiol 60:16-29


34. Leonardy S (2009) Regulierung der Polarität des A-Bewegungssystems in M. xanthus; PhD thesis


35. Strauch MA, Hoch JA (1993) Signal transduction in Bacillus subtilis sporulation. Curr Opin Genet Dev 3:203-212


36. Baker MD, Wolanin PM, Stock JB (2006) Signal transduction in bacterial chemotaxis. Bioessays 28:9-22


37. Appleby JL, Parkinson JS, Bourret RB (1996) Signal transduction via the multi- step phosphorelay: not necessarily a road less traveled. Cell 86:845-848


38. Scott AE, Simon E, Park SK, Andrews P, Zusman DR (2008) Site-specific receptor methylation of FrzCD in Myxococcus xanthus is controlled by a tetra-trico peptide repeat (TPR) containing regulatory domain of the FrzF methyltransferase. Mol Microbiol 69:724-735


39. Inclan YF, Laurent S, Zusman DR (2008) The receiver domain of FrzE, a CheA- CheY fusion protein, regulates the CheA histidine kinase activity and downstream signalling to the A-and S-motility systems of Myxococcus xanthus. Mol Microbiol 68:1328-1339


40. Gerding MA, Ogata Y, Pecora ND, Niki H, de Boer PA (2007) The trans- envelope Tol-Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli. Mol Microbiol 63:1008-1025


41. Rodrigue A, Quentin Y, Lazdunski A, Mejean V, Foglino M (2000) Two- component systems in Pseudomonas aeruginosa: why so many? Trends Microbiol 8:498-504


42. Wall D, Kaiser D (1999) Type IV pili and cell motility. Mol Microbiol 32:01-10


43. Inclan YF, Vlamakis HC, Zusman DR (2007) FrzZ, a dual CheY-like response regulator, functions as an output for the Frz chemosensory pathway of Myxococcus xanthus. Mol Microbiol 65:90-102


44. Pelicic V (2008) Type IV pili: e pluribus unum? Mol Microbiol 68:827-837


45. Mignot T, Merlie JP, Jr., Zusman DR (2005) Regulated pole-to-pole oscillations of a bacterial gliding motility protein. Science 310:855-857


46. Stock AM, Robinson VL, Goudreau PN (2000) Two-component signal transduction. Annu Rev Biochem 69:183-215


47. Dubnau D (1999) DNA uptake in bacteria. Annu Rev Microbiol 53:217-244


48. Pelling AE, Li Y, Shi W, Gimzewski JK (2005) Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy. Proc Natl Acad Sci U S A 102:6484-6489


49. Galperin M (2005) A census of membrane-bound and intracellular signal transduction proteins in bacteria: Bacterial IQ, extroverts and introverts. BMC Microbiology 5:35


50. Maier B, Potter L, So M, Long CD, Seifert HS, Sheetz MP (2002) Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A 99:16012-16017


51. Sambrook J, Russell DW (2001) Molecular cloning : a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.


52. Youderian P, Hartzell PL (2006) Transposon insertions of magellan-4 that impair social gliding motility in Myxococcus xanthus. Genetics 172:1397- 1410


53. Li Y et al. (2003) Extracellular polysaccharides mediate pilus retraction during social motility of Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 100:5443-5448


54. Goldman BS et al. (2006) Evolution of sensory complexity recorded in a myxobacterial genome. Proc Natl Acad Sci U S A 103:15200-15205


55. Julien B, Kaiser AD, Garza A (2000) Spatial control of cell differentiation in Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 97:9098-9103


56. Spormann AM, Kaiser AD (1995) Gliding movements in Myxococcus xanthus. J. Bacteriol. 177:5846-5852


57. Leonardy S, Freymark G, Hebener S, Ellehauge E, Sogaard-Andersen L (2007) Coupling of protein localization and cell movements by a dynamically localized response regulator in Myxococcus xanthus. Embo J 26:4433 References 137


58. Hartzell P, Kaiser D (1991a) Function of MglA, a 22-kilodalton protein essential for gliding in Myxococcus xanthus. J Bacteriol 173:7615-7624


59. Hartzell P, Kaiser D (1991b) Upstream gene of the mgl operon controls the level of MglA protein in Myxococcus xanthus. J Bacteriol 173:7625-7635


60. Jelsbak L, Søgaard-Andersen L (1999) The cell surface-associated intercellular C-signal induces behavioral changes in individual Myxococcus xanthus cells during fruiting body morphogenesis. Proc. Natl. Acad. Sci. USA 96:5031-5036


61. Hunter P (2008) Not so simple after all. A renaissance of research into prokaryotic evolution and cell structure. EMBO Rep 9:224-226


62. Jakovljevic V, Leonardy S, Hoppert M, Sogaard-Andersen L (2008) PilB and PilT are ATPases acting antagonistically in type IV pilus function in Myxococcus xanthus. J Bacteriol 190:2411-2421


63. Rosenberg E, Keller KH, Dworkin M (1977) Cell density-dependent growth of Myxococcus xanthus on casein. J Bacteriol 129:770-777


64. Wireman JW, Dworkin M (1977) Developmentally induced autolysis during fruiting body formation by Myxococcus xanthus. J Bacteriol 129:798-802


65. Jenal U, Galperin MY (2009) Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics. Curr. Opin. Microbiol. 12:152-160


66. Ulrich LE, Koonin EV, Zhulin IB (2005) One-component systems dominate signal transduction in prokaryotes. Trends Microbiol 13:52-56


67. Bulyha I et al. (2009) Regulation of the type IV pili molecular machine by dynamic localization of two motor proteins. Mol Microbiol 74:691-706


68. Paul R et al. (2008) Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate. Cell 133:452-461


69. Mauriello EM et al. (2010) Bacterial motility complexes require the actin-like protein, MreB and the Ras homologue, MglA. EMBO J 29:315-326


70. Muller FD, Treuner-Lange A, Heider J, Huntley SM, Higgs PI (2010) Global transcriptome analysis of spore formation in Myxococcus xanthus reveals a locus necessary for cell differentiation. BMC Genomics 11:264


71. Leonardy S, Miertzschke M, Bulyha I, Sperling E, Wittinghofer A, Sogaard- Andersen L (2010) Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J. 29:2276-2289


72. Galperin MY (2010) Diversity of structure and function of response regulator output domains. Curr. Opin. Microbiol. 13:150-159


73. Luciano J et al. (2011) Emergence and modular evolution of a novel motility machinery in bacteria. PLoS Genet 7:e1002268


74. Miertzschke M et al. (2011) Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. EMBO J. 30:4185-4197


75. Patryn J, Allen K, Dziewanowska K, Otto R, Hartzell PL (2010) Localization of MglA, an essential gliding motility protein in Myxococcus xanthus. Cytoskeleton (Hoboken) 67:322-337


76. Wuichet K, Cantwell BJ, Zhulin IB (2010) Evolution and phyletic distribution of two-component signal transduction systems. Curr. Opin. Microbiol. 13:219-225


77. Wuichet K, Zhulin IB (2010) Origins and diversification of a complex signal transduction system in prokaryotes. Sci Signal 3:ra50


78. Schramm, A., B. Lee, et al. (2012). "Intra-and interprotein phosphorylation between two-hybrid histidine kinases controls Myxococcus xanthus developmental progression." J Biol Chem 287(30): 25060-72.


79. Zhang Y, Guzzo M, Ducret A, Li YZ, Mignot T (2012) A dynamic response regulator protein modulates G-protein-dependent polarity in the bacterium Myxococcus xanthus. PLoS Genet 8:e1002872 List of publications


80. Keilberg D, Wuichet K, Drescher F, Sogaard-Andersen L (2012) A Response Regulator Interfaces between the Frz Chemosensory System and the MglA/MglB GTPase/GAP Module to Regulate Polarity in Myxococcus xanthus. PLoS Genet 8:e1002951


81. Skerker JM, Berg HC (2001) Direct observation of extension and retraction of type IV pili. Proc. Natl. Acad. Sci. USA 98:6901-6904


82. Kaiser D (1979) Social gliding is correlated with the presence of pili in Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 76:5952-5956


83. Hodgkin J, Kaiser D (1977) Cell-to-cell stimulation of movement in nonmotile mutants of Myxococcus. Proc. Natl. Acad. Sci. USA 74:2938-2942


84. Shimkets L, Woese CR (1992) A phylogenetic analysis of the myxobacteria: basis for their classification. Proc Natl Acad Sci U S A 89:9459-9463


85. Yang R et al. (2004) AglZ is a filament-forming coiled-coil protein required for adventurous gliding motility of Myxococcus xanthus. J Bacteriol 186:6168-6178


86. Craig L, Li J (2008) Type IV pili: paradoxes in form and function. Curr Opin Struct Biol 18:267-277


87. Sun H, Zusman DR, Shi W (2000) Type IV pilus of Myxococcus xanthus is a motility apparatus controlled by the frz chemosensory system. Current Biology 10:1143-1146


88. Maddock JR, Shapiro L (1993) Polar location of the chemoreceptor complex in the Escherichia coli cell. Science 259:1717-1723


89. Vetter IR, Wittinghofer A (2001) The guanine nucleotide-binding switch in three dimensions. Science 294:1299-1304


90. Ridley AJ et al. (2003) Cell migration: integrating signals from front to back. Science 302:1704-1709


91. Lenarcic R et al. (2009) Localisation of DivIVA by targeting to negatively curved membranes. EMBO J 28:2272-2282