Untersuchung der Funktion der N-terminalen Verlängerung von GBP 130 von Plasmodium falciparum

Plasmodium falciparum exportiert Proteine in den Wirtserythrozyt, die die Wirtszelle morphologisch modifizieren. Eine wichtige Konsequenz dieser morphologischen Veränderung der Wirtszelle ist die Eigenschaft der infizierten Zellen an Rezeptoren im Endothel der Blutgefässe zu binden. Diese adhäsiven...

Full description

Saved in:
Bibliographic Details
Main Author: Barniol, Luis F.
Contributors: Przyborski, Jude (PD Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2013
Biologie
Subjects:
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!

1. Plattner, F., and D. Soldati-Favre, 2008, Hijacking of host cellular functions by the Apicomplexa: Annu Rev Microbiol, v. 62, p. 471-87.


2. Wiedmann, M., D. Goerlich, E. Hartmann, T. V. Kurzchalia, and T. A. Rapoport, 1989, Photocrosslinking demonstrates proximity of a 34 kDa membrane protein to different portions of preprolactin during translocation through the endoplasmic reticulum: FEBS Lett, v. 257, p. 263-8.


3. Perkins, M. E., 1984, Binding of glycophorins to Plasmodium falciparum merozoites: Mol Biochem Parasitol, v. 10, p. 67-78.


4. Ragge, K., H. H. Arnold, M. Tümmler, B. Knapp, E. Hundt, and K. Lingelbach, 1990, In vitro biosynthesis and membrane translocation of the serine rich protein of Plasmodium falciparum: Mol Biochem Parasitol, v. 42, p. 93-100.


5. Günther, K., M. Tümmler, H. H. Arnold, R. Ridley, M. Goman, J. G. Scaife, and K. Lingelbach, 1991, An exported protein of Plasmodium falciparum is synthesized as an integral membrane protein: Mol Biochem Parasitol, v. 46, p. 149-57.


6. de Castro, F. A., G. E. Ward, R. Jambou, G. Attal, V. Mayau, G. Jaureguiberry, C. Braun- Breton, D. Chakrabarti, and G. Langsley, 1996, Identification of a family of Rab G- proteins in Plasmodium falciparum and a detailed characterisation of pfrab6: Mol Biochem Parasitol, v. 80, p. 77-88.


7. Kang, S. W., N. S. Rane, S. J. Kim, J. L. Garrison, J. Taunton, and R. S. Hegde, 2006, Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway: Cell, v. 127, p. 999-1013.


8. Tonkin, C. J., J. A. Pearce, G. I. McFadden, and A. F. Cowman, 2006, Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum: Curr Opin Microbiol, v. 9, p. 381-7.


9. Bullen, H. E., B. S. Crabb, and P. R. Gilson, 2012, Recent insights into the export of PEXEL/HTS-motif containing proteins in Plasmodium parasites: Curr Opin Microbiol.


10. Sato, S., and R. J. Wilson, 2004, The use of DsRED in single-and dual-color fluorescence labeling of mitochondrial and plastid organelles in Plasmodium falciparum: Mol Biochem Parasitol, v. 134, p. 175-9.


11. Lingelbach, K., and J. M. Przyborski, 2006, The long and winding road: protein trafficking mechanisms in the Plasmodium falciparum infected erythrocyte: Mol Biochem Parasitol, v. 147, p. 1-8.


12. Plath, K., W. Mothes, B. M. Wilkinson, C. J. Stirling, and T. A. Rapoport, 1998, Signal sequence recognition in posttranslational protein transport across the yeast ER membrane: Cell, v. 94, p. 795-807.


13. Robinson, C., P. J. Hynds, D. Robinson, and A. Mant, 1998, Multiple pathways for the targeting of thylakoid proteins in chloroplasts: Plant Mol Biol, v. 38, p. 209-21.


14. Meyer, D. I., E. Krause, and B. Dobberstein, 1982, Secretory protein translocation across membranes-the role of the "docking protein': Nature, v. 297, p. 647-50.


15. Vincensini, L., S. Richert, T. Blisnick, A. Van Dorsselaer, E. Leize-Wagner, T. Rabilloud, and C. Braun Breton, 2005, Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretory compartment delivering Plasmodium falciparum proteins to the surface of its host cell: Mol Cell Proteomics, v. 4, p. 582-93.


16. Lingelbach, K., 1997, Protein trafficking in the Plasmodium-falciparum-infected erythrocyte-- from models to mechanisms: Ann Trop Med Parasitol, v. 91, p. 543-9.


17. Connolly, T., and R. Gilmore, 1986, Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein: J Cell Biol, v. 103, p. 2253-61.


18. Krieg, U. C., A. E. Johnson, and P. Walter, 1989, Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel: J Cell Biol, v. 109, p. 2033-43.


19. Martoglio, B., R. Graf, and B. Dobberstein, 1997, Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin: EMBO J, v. 16, p. 6636-45.


20. Haldar, K., and N. Mohandas, 2007, Erythrocyte remodeling by malaria parasites: Curr Opin Hematol, v. 14, p. 203-9.


21. Cyrklaff, M., C. P. Sanchez, N. Kilian, C. Bisseye, J. Simpore, F. Frischknecht, and M. Lanzer, 2011, Hemoglobins S and C interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes: Science, v. 334, p. 1283-6.


22. Struck, N. S., S. Herrmann, C. Langer, A. Krueger, B. J. Foth, K. Engelberg, A. L. Cabrera, S. Haase, M. Treeck, M. Marti, A. F. Cowman, T. Spielmann, and T. W. Gilberger, 2008a, Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher-and lower-eukaryote-like mechanism: J Cell Sci, v. 121, p. 2123-9.


23. Struck, N. S., S. de Souza Dias, C. Langer, M. Marti, J. A. Pearce, A. F. Cowman, and T. W. Gilberger, 2005, Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP: J Cell Sci, v. 118, p. 5603-13.


24. Lanzer, 2005, Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum-infected erythrocytes: EMBO J, v. 24, p. 2306-17.


25. Sargeant, T. J., M. Marti, E. Caler, J. M. Carlton, K. Simpson, T. P. Speed, and A. F. Cowman, 2006, Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites: Genome Biol, v. 7, p. R12.


26. Struck, N. S., S. Herrmann, I. Schmuck-Barkmann, S. de Souza Dias, S. Haase, A. L. Cabrera, M. Treeck, C. Bruns, C. Langer, A. F. Cowman, M. Marti, T. Spielmann, and T. W. Gilberger, 2008b, Spatial dissection of the cis-and trans-Golgi compartments in the malaria parasite Plasmodium falciparum: Mol Microbiol, v. 67, p. 1320-30.


27. Cooke, B. M., D. W. Buckingham, F. K. Glenister, K. M. Fernandez, L. H. Bannister, M. Marti, N. Mohandas, and R. L. Coppel, 2006, A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells: J Cell Biol, v. 172, p. 899-908.


28. Lingelbach, K., and K. A. Joiner, 1998, The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells: J Cell Sci, v. 111 ( Pt 11), p. 1467-75.


29. Müller, M., I. Ibrahimi, C. N. Chang, P. Walter, and G. Blobel, 1982, A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum: J Biol Chem, v. 257, p. 11860-3.


30. Pologe, L. G., and J. V. Ravetch, 1986, A chromosomal rearrangement in a P. falciparum histidine-rich protein gene is associated with the knobless phenotype: Nature, v. 322, p. 474-7.


31. Haldar, 2004, A host-targeting signal in virulence proteins reveals a secretome in malarial infection: Science, v. 306, p. 1934-7.


32. Lauer, S. A., P. K. Rathod, N. Ghori, and K. Haldar, 1997, A membrane network for nutrient import in red cells infected with the malaria parasite: Science, v. 276, p. 1122-5.


33. von Heijne, G., 1984, Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells: EMBO J, v. 3, p. 2315-8.


34. von Heijne, G., 1986, A new method for predicting signal sequence cleavage sites: Nucleic Acids Res, v. 14, p. 4683-90.


35. Jungnickel, B., and T. A. Rapoport, 1995, A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane: Cell, v. 82, p. 261-70.


36. Perlman, D., and H. O. Halvorson, 1983, A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides: J Mol Biol, v. 167, p. 391- 409.


37. Kochan, J., M. Perkins, and J. V. Ravetch, 1986, A tandemly repeated sequence determines the binding domain for an erythrocyte receptor binding protein of P. falciparum: Cell, v. 44, p. 689-96.


38. James, P., T. Vorherr, and E. Carafoli, 1995, Calmodulin-binding domains: just two faced or multi-faceted?: Trends Biochem Sci, v. 20, p. 38-42.


39. Sidjanski, S., and J. P. Vanderberg, 1997, Delayed migration of Plasmodium sporozoites from the mosquito bite site to the blood: Am J Trop Med Hyg, v. 57, p. 426-9.


40. Talmadge, K., S. Stahl, and W. Gilbert, 1980, Eukaryotic signal sequence transports insulin antigen in Escherichia coli: Proc Natl Acad Sci U S A, v. 77, p. 3369-73.


41. Maier, A. G., M. Rug, M. T. O'Neill, M. Brown, S. Chakravorty, T. Szestak, J. Chesson, Y. Wu, K. Hughes, R. L. Coppel, C. Newbold, J. G. Beeson, A. Craig, B. S. Crabb, and A. F. Cowman, 2008, Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes: Cell, v. 134, p. 48-61.


42. Langreth, S. G., J. B. Jensen, R. T. Reese, and W. Trager, 1978, Fine structure of human malaria in vitro: J Protozool, v. 25, p. 443-52.


43. Spycher, C., M. Rug, N. Klonis, D. J. Ferguson, A. F. Cowman, H. P. Beck, and L. Tilley, 2006, Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum- infected erythrocytes: Mol Cell Biol, v. 26, p. 4074-85.


44. Schatz, P. J., and J. Beckwith, 1990, Genetic analysis of protein export in Escherichia coli: Annu Rev Genet, v. 24, p. 215-48.


45. Walliker, D., I. A. Quakyi, T. E. Wellems, T. F. McCutchan, A. Szarfman, W. T. London, L. M. Corcoran, T. R. Burkot, and R. Carter, 1987, Genetic analysis of the human malaria parasite Plasmodium falciparum: Science, v. 236, p. 1661-6.


46. Trager, W., and J. B. Jensen, 1976, Human malaria parasites in continuous culture: Science, v. 193, p. 673-5.


47. Van Wye, J., N. Ghori, P. Webster, R. R. Mitschler, H. G. Elmendorf, and K. Haldar, 1996, Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi, in Plasmodium falciparum: Mol Biochem Parasitol, v. 83, p. 107-20.


48. Haldar, K., 1998, Intracellular trafficking in Plasmodium-infected erythrocytes: Curr Opin Microbiol, v. 1, p. 466-71.


49. Cowman, A. F., and B. S. Crabb, 2006, Invasion of red blood cells by malaria parasites: Cell, v. 124, p. 755-66.


50. Ravetch, J. V., J. Kochan, and M. Perkins, 1985, Isolation of the gene for a glycophorin- binding protein implicated in erythrocyte invasion by a malaria parasite: Science, v. 227, p. 1593-7.


51. Cox-Singh, J., and B. Singh, 2008, Knowlesi malaria: newly emergent and of public health importance?: Trends Parasitol, v. 24, p. 406-10.


52. Sturm, A., R. Amino, C. van de Sand, T. Regen, S. Retzlaff, A. Rennenberg, A. Krueger, J. M. Pollok, R. Menard, and V. T. Heussler, 2006, Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids: Science, v. 313, p. 1287-90.


53. Kaiser, C. A., D. Preuss, P. Grisafi, and D. Botstein, 1987, Many random sequences functionally replace the secretion signal sequence of yeast invertase: Science, v. 235, p. 312-7.


54. Walter, P., and V. R. Lingappa, 1986, Mechanism of protein translocation across the endoplasmic reticulum membrane: Annu Rev Cell Biol, v. 2, p. 499-516.


55. Chang, H. H., A. M. Falick, P. M. Carlton, J. W. Sedat, J. L. DeRisi, and M. A. Marletta, 2008, N-terminal processing of proteins exported by malaria parasites: Mol Biochem Parasitol, v. 160, p. 107-15.


56. von Heijne, G., 1983, Patterns of amino acids near signal-sequence cleavage sites: Eur J Biochem, v. 133, p. 17-21.


57. Russo, I., S. Babbitt, V. Muralidharan, T. Butler, A. Oksman, and D. E. Goldberg, 2010, Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte: Nature, v. 463, p. 632-6.


58. Cox-Singh, J., T. M. Davis, K. S. Lee, S. S. Shamsul, A. Matusop, S. Ratnam, H. A. Rahman, D. J. Conway, and B. Singh, 2008, Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening: Clin Infect Dis, v. 46, p. 165-71.


59. Spielmann, T., and T. W. Gilberger, 2010, Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?: Trends Parasitol, v. 26, p. 6-10.


60. Kats, L. M., B. M. Cooke, R. L. Coppel, and C. G. Black, 2008, Protein trafficking to apical organelles of malaria parasites -building an invasion machine: Traffic, v. 9, p. 176-86.


61. Pasvol, G., R. J. Wilson, M. E. Smalley, and J. Brown, 1978, Separation of viable schizont- infected red cells of Plasmodium falciparum from human blood: Ann Trop Med Parasitol, v. 72, p. 87-8.


62. sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis: J Exp Med, v. 187, p. 813-8.


63. Walter, P., and A. E. Johnson, 1994, Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane: Annu Rev Cell Biol, v. 10, p. 87-119.


64. Martoglio, B., and B. Dobberstein, 1998, Signal sequences: more than just greasy peptides: Trends Cell Biol, v. 8, p. 410-5.


65. Ng, D. T., J. D. Brown, and P. Walter, 1996, Signal sequences specify the targeting route to the endoplasmic reticulum membrane: J Cell Biol, v. 134, p. 269-78.


66. von Heijne, G., 1985, Signal sequences. The limits of variation: J Mol Biol, v. 184, p. 99-105.


67. Maier, A. G., M. Rug, M. T. O'Neill, J. G. Beeson, M. Marti, J. Reeder, and A. F. Cowman, 2007, Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface: Blood, v. 109, p. 1289-97.


68. Perkins, M., 1988, Stage-dependent processing and localization of a Plasmodium falciparum protein of 130,000 molecular weight: Exp Parasitol, v. 65, p. 61-8.


69. Smith, J. D., C. E. Chitnis, A. G. Craig, D. J. Roberts, D. E. Hudson-Taylor, D. S. Peterson, R. Pinches, C. I. Newbold, and L. H. Miller, 1995, Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes: Cell, v. 82, p. 101-10.


70. Crabb, B. S., B. M. Cooke, J. C. Reeder, R. F. Waller, S. R. Caruana, K. M. Davern, M. E. Wickham, G. V. Brown, R. L. Coppel, and A. F. Cowman, 1997, Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress: Cell, v. 89, p. 287-96.


71. Marti, M., R. T. Good, M. Rug, E. Knuepfer, and A. F. Cowman, 2004, Targeting malaria virulence and remodeling proteins to the host erythrocyte: Science, v. 306, p. 1930-3.


72. Braud, V., E. Y. Jones, and A. McMichael, 1997, The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9: Eur J Immunol, v. 27, p. 1164-9.


73. Su, X. Z., V. M. Heatwole, S. P. Wertheimer, F. Guinet, J. A. Herrfeldt, D. S. Peterson, J. A. Ravetch, and T. E. Wellems, 1995, The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes: Cell, v. 82, p. 89-100.


74. Kurys, G., Y. Tagaya, R. Bamford, J. A. Hanover, and T. A. Waldmann, 2000, The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15: J Biol Chem, v. 275, p. 30653-9.


75. Miller, L. H., D. I. Baruch, K. Marsh, and O. K. Doumbo, 2002, The pathogenic basis of malaria: Nature, v. 415, p. 673-9.


76. de Gier, J. W., and J. Luirink, 2003, The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins: EMBO Rep, v. 4, p. 939-43.


77. Rug, M., S. W. Prescott, K. M. Fernandez, B. M. Cooke, and A. F. Cowman, 2006, The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes: Blood, v. 108, p. 370-8.


78. Howard, R. F., and C. M. Schmidt, 1995, The secretary pathway of plasmodium falciparum regulates transport of p82/RAP1 to the rhoptries: Mol Biochem Parasitol, v. 74, p. 43- 54.


79. Connolly, T., and R. Gilmore, 1989, The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide: Cell, v. 57, p. 599-610.


80. Lee, H. C., and H. D. Bernstein, 2001, The targeting pathway of Escherichia coli presecretory and integral membrane proteins is specified by the hydrophobicity of the targeting signal: Proc Natl Acad Sci U S A, v. 98, p. 3471-6.


81. Stuart, R. A., and W. Neupert, 1996, Topogenesis of inner membrane proteins of mitochondria: Trends Biochem Sci, v. 21, p. 261-7.


82. Walter, P., and G. Blobel, 1981, Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site- specific arrest of chain elongation that is released by microsomal membranes: J Cell Biol, v. 91, p. 557-61.


83. Lee, H. C., and H. D. Bernstein, 2002, Trigger factor retards protein export in Escherichia coli: J Biol Chem, v. 277, p. 43527-35.


84. Haase, S., S. Herrmann, C. Grüring, A. Heiber, P. W. Jansen, C. Langer, M. Treeck, A. Cabrera, C. Bruns, N. S. Struck, M. Kono, K. Engelberg, U. Ruch, H. G. Stunnenberg, T. W. Gilberger, and T. Spielmann, 2009, Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2: Mol Microbiol, v. 71, p. 1003- 17.


85. Cesbron-Delauw, M. F., C. Gendrin, L. Travier, P. Ruffiot, and C. Mercier, 2008, Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole: Traffic, v. 9, p. 657-64.


86. Connolly, T., P. Rapiejko, and R. Gilmore, 1991, Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor: Science, v. 252, p. 1171-3.


87. Lambros, C., and J. P. Vanderberg, 1979, Synchronization of Plasmodium falciparum erythrocytic stages in culture: J Parasitol, v. 65, p. 418-20.


88. Rossner, M., and K. M. Yamada, 2004, What's in a picture? The temptation of image manipulation: J Cell Biol, v. 166, p. 11-5.


89. Klausner, R. D., J. G. Donaldson, and J. Lippincott-Schwartz, 1992, Brefeldin A: insights into the control of membrane traffic and organelle structure: J Cell Biol, v. 116, p. 1071- 80.


90. Lauer, S., J. VanWye, T. Harrison, H. McManus, B. U. Samuel, N. L. Hiller, N. Mohandas, and K. Haldar, 2000, Vacuolar uptake of host components, and a role for cholesterol and sphingomyelin in malarial infection: EMBO J, v. 19, p. 3556-64.


91. Li, Y., J. J. Bergeron, L. Luo, W. J. Ou, D. Y. Thomas, and C. Y. Kang, 1996, Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport: Proc Natl Acad Sci U S A, v. 93, p. 9606-11.


92. Kyte, J., and R. F. Doolittle, 1982, A simple method for displaying the hydropathic character of a protein: J Mol Biol, v. 157, p. 105-32.