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The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry
The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...
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| 主要作者: | |
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| 其他作者: | |
| 格式: | Dissertation |
| 語言: | 英语 |
| 出版: |
Philipps-Universität Marburg
2012
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| 主題: | |
| 在線閱讀: | PDF-Volltext |
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PDF-Volltext| 索引號: |
urn:nbn:de:hebis:04-z2012-06004 |
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| Publikationsdatum: |
2012-07-11 |
| Datum der Annahme: |
2012-04-25 |
| Downloads: |
35 (2024), 68 (2023), 48 (2022), 58 (2021), 54 (2020), 175 (2019), 146 (2018) |
| Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
| Zugangs-URL: |
https://archiv.ub.uni-marburg.de/diss/z2012/0600 https://doi.org/10.17192/z2012.0600 |