The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry
The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...
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Andere auteurs: | |
Formaat: | Dissertation |
Taal: | Engels |
Gepubliceerd in: |
Philipps-Universität Marburg
2012
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Onderwerpen: | |
Online toegang: | PDF Full text |
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PDF Full textPlaatsingsnummer: |
urn:nbn:de:hebis:04-z2012-06004 |
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Publicatiedatum: |
2012-07-11 |
Datum der Annahme: |
2012-04-25 |
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Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL naar item: |
https://archiv.ub.uni-marburg.de/diss/z2012/0600 https://doi.org/10.17192/z2012.0600 |