The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...

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I tiakina i:
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Kaituhi matua: Biela, Adam
Ētahi atu kaituhi: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Hōputu: Dissertation
Reo:Ingarihi
I whakaputaina: Philipps-Universität Marburg 2012
Ngā marau:
Thrombin
Medizin
ITC
Water Network
Thermolysin
Hydrophobic Effect
Wassernetzwerk
Hydrophober Effekt
Medical sciences Medicine
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Tau karanga: urn:nbn:de:hebis:04-z2012-06004
Rā whakaputa: 2012-07-11
Datum der Annahme: 2012-04-25
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL Uru: https://archiv.ub.uni-marburg.de/diss/z2012/0600
https://doi.org/10.17192/z2012.0600

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