The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autore principale: Biela, Adam
Altri autori: Klebe, Gerhard (Prof. Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2012
Soggetti:
Thrombin
Medizin
ITC
Water Network
Thermolysin
Hydrophobic Effect
Wassernetzwerk
Hydrophober Effekt
Medical sciences Medicine
Accesso online:PDF Full Text
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!

Accesso online

PDF Full Text

Dettagli sul posseduto da
Collocazione: urn:nbn:de:hebis:04-z2012-06004
Data di pubblicazione: 2012-07-11
Datum der Annahme: 2012-04-25
Downloads: 35 (2024), 68 (2023), 48 (2022), 58 (2021), 54 (2020), 175 (2019), 146 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL di accesso: https://archiv.ub.uni-marburg.de/diss/z2012/0600
https://doi.org/10.17192/z2012.0600

Documenti analoghi