The Role of Water in Protein-Ligand Binding: A Comprehensive Study by Crystallography and Isothermal Titration Calorimetry

The aim of this work is to investigate the impact of desolvation effects on protein-ligand interactions. In all complex structures with thrombin and pyridine, it is evident that preserving the original solvation state of Asp189 is a crucial and a common feature upon binding of the pyridine inhibitor...

Full description

Saved in:
Bibliographic Details
Main Author: Biela, Adam
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:English
Published: Philipps-Universität Marburg 2012
Pharmazeutische Chemie
Subjects:
ITC
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!
No citations were found for this record.