Interim Design Modifications in Time-to-Event Studies

Interim Design Modifications in Time-to-Event Studies

We propose a flexible method for interim design modifications in time-to-event studies. With this method, it is possible to inspect the data at any time during the course of the study, without the need for pre-specification of a learning phase, and to make certain types of design modifications depen...

Olles dieđut

Furkejuvvon:
Bibliográfalaš dieđut
Váldodahkki: Irle, Sebastian
Eará dahkkit: Schäfer, Helmut (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Materiálatiipa: Dissertation
Giella:eaŋgalasgiella
Almmustuhtton: Philipps-Universität Marburg 2012
Fáttát:
CRP principle
Logrank statistic
Adaptives Verfahren
Medizin
Adaptive design
Conditional rejection probability
Kontrollierte klinische Studie
Conditional distribution
Medical sciences Medicine
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