Interim Design Modifications in Time-to-Event Studies

Interim Design Modifications in Time-to-Event Studies

We propose a flexible method for interim design modifications in time-to-event studies. With this method, it is possible to inspect the data at any time during the course of the study, without the need for pre-specification of a learning phase, and to make certain types of design modifications depen...

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Autore principale: Irle, Sebastian
Altri autori: Schäfer, Helmut (Prof. Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2012
Soggetti:
Conditional rejection probability
CRP principle
Adaptive design
Conditional distribution
Adaptives Verfahren
Medizin
Logrank statistic
Kontrollierte klinische Studie
Medical sciences Medicine
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