Biodegradable Amphiphilic Block Copolymers:Synthesis, Characterization and Properties Evaluation

Different biodegradable amphiphilic block copolymers were prepared by melt-polycondensation. These block copolymers are composed of different molar ratio of two segments, 1st is hydrophilic block which is methoxy poly(ethylene oxide) MPEO of two different molecular weights, (5000 and 2000 g/mol). The hydrophobic segments are aliphatic poly ester of poly hexylene adipate PHA, polybutylene succinate PBS, polyhexylene succinate PHS and polybutylene adipate PBA. Full characterization of these block copolymers have been achieved using GPC, NMR, Thermal analysis, and X-ray analysis. Hydrolytic and enzymatic degradation have been done. Loading of PHA-b-MPEO5 with pH sensitive moiety is also achieved. Values of cmc of two commercially available surfactants as well as two samples of our polymers were measured by fluorescence spectroscopy using pyrene as a probe