Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide mediates differential signaling through PAC1 receptor splice variants and activates non-canonical cAMP dependent gene induction in the nervous system - Implications for homeostatic stress-responding

Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the nervous system, important for homeostatic responses to stress...

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Detalhes bibliográficos
Autor principal: Holighaus, Yvonne
Outros Autores: Weihe, Eberhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2011
Assuntos:
nervous system
Nervensystem
G protein-coupled receptors
signal transduction
Neuropeptide
G-Protein gekoppelte Rezeptoren
neuropharmacology
Neuropharmakologie
stress
PACAP
neuropeptides
Signaltransduktion
Naturwissenschaften
Genexpression
Stress
gene expression
Natural sciences & mathematics
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