Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis

Diese Studie untersuchte an 111 Patienten mit Sepsis den Zusammenhang der zeitlichen Kinetik von Interleukin 6, Procalcitonin und der HLA-DR-Expression auf Monozyten mit dem Krankheitsverlauf sowie ihre Eignung zu einer frühen Risikostratifizierung. Es zeigte sich in den aufgestellten logistischen R...

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1. Verfasser: Schumann, Florian
Beteiligte: Max, M. (PD Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Deutsch
Veröffentlicht: Philipps-Universität Marburg 2011
Klinik für Anästhesie und Intensivtherapie
Ausgabe:http://dx.doi.org/10.17192/z2011.0548
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topic Sepsis
Interleukin 6
HLA-DR
HLA-DR
Sepsis
Procalcitonin
Medizin, Gesundheit
Procalcitonin
Interleukin 6
spellingShingle Sepsis
Interleukin 6
HLA-DR
HLA-DR
Sepsis
Procalcitonin
Medizin, Gesundheit
Procalcitonin
Interleukin 6
Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
This study analysed at 111 patients with sepsis the relation of the temporal kinetics of interleukin 6, procalcitonin and HLA-DR expression on monocytes with the disease and their ability for early risk stratification. It was found in the developed logistic regression models a statistical trend, that after 48 hours the HLA-DR expression on monocytes can give evidence of the further clinical development of the patient and thus potentially of the effectiveness of the current therapy of sepsis (p = 0.0923). Certainly there are further multicenter studies with larger study populations necessary to detect a statistically significant and positive effect on the outcome. For PCT and IL-6 there was neither a statistical significance nor a statistical trend found in this regard. In addition, in the created Cox regression models the already by other research groups proven suitability of the APACHE II score for early risk stratification was confirmed (p = 0.0098). For IL-6 as well such an association with the risk of death could be shown (p = 0.0148). For PCT and HLA-DR no association with the risk of death was detectable.
Schumann, Florian
url http://archiv.ub.uni-marburg.de/diss/z2011/0548/pdf/dfs.pdf
title Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
title_short Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
title_full Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
title_fullStr Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
title_full_unstemmed Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
title_sort Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis
author2 Max, M. (PD Dr.)
author2_role ths
title_alt Analysis of the correlation of HLA-DR expression, procalcitonin and interleukin 6 with the course of disease and their ability for risk stratification in patients with sepsis
contents This study analysed at 111 patients with sepsis the relation of the temporal kinetics of interleukin 6, procalcitonin and HLA-DR expression on monocytes with the disease and their ability for early risk stratification. It was found in the developed logistic regression models a statistical trend, that after 48 hours the HLA-DR expression on monocytes can give evidence of the further clinical development of the patient and thus potentially of the effectiveness of the current therapy of sepsis (p = 0.0923). Certainly there are further multicenter studies with larger study populations necessary to detect a statistically significant and positive effect on the outcome. For PCT and IL-6 there was neither a statistical significance nor a statistical trend found in this regard. In addition, in the created Cox regression models the already by other research groups proven suitability of the APACHE II score for early risk stratification was confirmed (p = 0.0098). For IL-6 as well such an association with the risk of death could be shown (p = 0.0148). For PCT and HLA-DR no association with the risk of death was detectable.
license_str http://archiv.ub.uni-marburg.de/adm/urhg.html
oai_set_str_mv open_access
doc-type:doctoralThesis
ddc:610
xMetaDissPlus
publishDate 2011
era_facet 2011
institution Klinik für Anästhesie und Intensivtherapie
description Diese Studie untersuchte an 111 Patienten mit Sepsis den Zusammenhang der zeitlichen Kinetik von Interleukin 6, Procalcitonin und der HLA-DR-Expression auf Monozyten mit dem Krankheitsverlauf sowie ihre Eignung zu einer frühen Risikostratifizierung. Es zeigte sich in den aufgestellten logistischen Regressionsmodellen ein statistischer Trend, wonach die HLA-DR-Expression auf Monozyten nach 48 Stunden Hinweise auf die weitere klinische Entwicklung des Patienten und damit möglicherweise auf die Wirksamkeit der aktuellen Sepsistherapie geben kann (p=0,0923). Es sind hier jedoch weitere multizentrische Studien mit größeren Studienkollektiven nötig, um eine statistische Signifikanz und einen positiven Effekt auf das Outcome nachzuweisen. Für PCT und IL-6 zeigten sich diesbezüglich weder eine statistische Signifikanz noch ein statistischer Trend. Des Weiteren bestätigte sich in den erstellten Cox-Regressionsmodellen die schon durch andere Forschergruppen nachgewiesene Eignung des APACHE II-Scores zur frühen Risikostratifizierung (p=0,0098). Für IL-6 konnte ebenfalls eine solche Assoziation mit dem Sterberisiko gezeigt werden (p=0,0148). Für PCT und HLA-DR war keine Assoziation mit dem Sterberisiko nachzuweisen.
language German
format Dissertation
first_indexed 2011-08-22T00:00:00Z
ref_str_mv references
author Schumann, Florian
last_indexed 2011-09-13T23:59:59Z
publisher Philipps-Universität Marburg
doi_str_mv http://dx.doi.org/10.17192/z2011.0548
edition http://dx.doi.org/10.17192/z2011.0548
dewey-raw 610
dewey-search 610
genre Medical sciences, Medicine
genre_facet Medical sciences, Medicine
topic_facet Medizin, Gesundheit
building Medizin
thumbnail http://archiv.ub.uni-marburg.de/diss/z2011/0548/cover.png
spelling diss/z2011/0548 Untersuchung zur Korrelation von HLA-DR-Expression, Procalcitonin und Interleukin 6 mit dem Krankheitsverlauf sowie ihrer Eignung zur Risikostratifizierung bei Patienten mit Sepsis Analysis of the correlation of HLA-DR expression, procalcitonin and interleukin 6 with the course of disease and their ability for risk stratification in patients with sepsis This study analysed at 111 patients with sepsis the relation of the temporal kinetics of interleukin 6, procalcitonin and HLA-DR expression on monocytes with the disease and their ability for early risk stratification. It was found in the developed logistic regression models a statistical trend, that after 48 hours the HLA-DR expression on monocytes can give evidence of the further clinical development of the patient and thus potentially of the effectiveness of the current therapy of sepsis (p = 0.0923). Certainly there are further multicenter studies with larger study populations necessary to detect a statistically significant and positive effect on the outcome. For PCT and IL-6 there was neither a statistical significance nor a statistical trend found in this regard. In addition, in the created Cox regression models the already by other research groups proven suitability of the APACHE II score for early risk stratification was confirmed (p = 0.0098). For IL-6 as well such an association with the risk of death could be shown (p = 0.0148). For PCT and HLA-DR no association with the risk of death was detectable. 2011 urn:nbn:de:hebis:04-z2011-05480 2011-08-18 Diese Studie untersuchte an 111 Patienten mit Sepsis den Zusammenhang der zeitlichen Kinetik von Interleukin 6, Procalcitonin und der HLA-DR-Expression auf Monozyten mit dem Krankheitsverlauf sowie ihre Eignung zu einer frühen Risikostratifizierung. Es zeigte sich in den aufgestellten logistischen Regressionsmodellen ein statistischer Trend, wonach die HLA-DR-Expression auf Monozyten nach 48 Stunden Hinweise auf die weitere klinische Entwicklung des Patienten und damit möglicherweise auf die Wirksamkeit der aktuellen Sepsistherapie geben kann (p=0,0923). Es sind hier jedoch weitere multizentrische Studien mit größeren Studienkollektiven nötig, um eine statistische Signifikanz und einen positiven Effekt auf das Outcome nachzuweisen. Für PCT und IL-6 zeigten sich diesbezüglich weder eine statistische Signifikanz noch ein statistischer Trend. Des Weiteren bestätigte sich in den erstellten Cox-Regressionsmodellen die schon durch andere Forschergruppen nachgewiesene Eignung des APACHE II-Scores zur frühen Risikostratifizierung (p=0,0098). Für IL-6 konnte ebenfalls eine solche Assoziation mit dem Sterberisiko gezeigt werden (p=0,0148). Für PCT und HLA-DR war keine Assoziation mit dem Sterberisiko nachzuweisen. 2011-08-22 Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J. Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am.J.Respir.Crit Care Med. 2008: 177: 498-505. 2008 Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A pro- spective study. Journal of the American Medical Association 1995: 273: 117-23. 1995 The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study Meisner M, Tschaikowsky K, Palmaers T, Schmidt J. Comparison of procalci- tonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care (Lond). 1999: 3: 45-50. 1999 Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS Presterl E, Staudinger T, Pettermann M, Lassnigg A, Burgmann H, Winkler S, Frass M, Graninger W. Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis. Am J Respir Crit Care Med. 1997: 156: 825-32. 1997 Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., and Pinsky, M. R. Epidemiology of severe sepsis in the United States: analysis of in- cidence, outcome and associated costs of care. Critical Care Medicine 29, 1303- 1310. 2001. Ref Type: Journal (Full) 2001 Epidemiology of severe sepsis in the United States: analysis of incidence , outcome and associated costs of care Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Na- ture 1998: 392: 245-52. 1998 Dendritic cells and the control of immunity Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J. Adult- population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004: 30: 589-96. 2004 Adultpopulation incidence of severe sepsis in Australian and New Zealand intensive care units Moreno RP, Metnitz B, Adler L, Hoechtl A, Bauer P, Metnitz PG. Sepsis mor- tality prediction based on predisposition, infection and response. Intensive Care Med. 2008: 34: 496-504. 2008 Sepsis mortality prediction based on predisposition, infection and response Vincent JL. Dear SIRS, I'm sorry to say that I don't like you.. Crit Care Med. 1997: 25: 372-4. 1997 Dear SIRS, I'm sorry to say that I don't like you Florian Schumann, * 23.01.1981 in Siegburg, evangelisch Berufliche Tätigkeit 08/2009 -heute Assistenzarzt in der Klinik für Innere Medizin am St. Vinzenz Krankenhaus Hanau 01.1981 in Siegburg, evangelisch Berufliche Tätigkeit 08/2009 -heute Assistenzarzt in der Klinik für Innere Medizin am St Members of the ACCP / SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Consensus Con- ference: definitions for sepsis and organ failure and guidelines for the use of in- novative therapies in sepsis. Crit Care Med. 1992: 20: 864-74. 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Le G, Jr., Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. Journal of the American Medical Association 1993: 270: 2957-63. 1993 A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985: 13: 818-29. 1985 APACHE II: a severity of disease classification system Wunder C, Eichelbronner O, Roewer N. Are IL-6, IL-10 and PCT plasma con- centrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II. Inflamm.Res. 2004: 53: 158-63. 2004 Are IL-6, IL-10 and PCT plasma concentrations reliable for outcome prediction in severe sepsis? A comparison with APACHE III and SAPS II Meisner M. Biomarkers of sepsis: clinically useful? Curr.Opin.Crit Care. 2005: 11: 473-80. 2005 Biomarkers of sepsis: clinically useful? Igonin AA, Armstrong VW, Shipkova M, Lazareva NB, Kukes VG, Oellerich M. Circulating cytokines as markers of systemic inflammatory response in se- vere community-acquired pneumonia. Clin Biochem. 2004: 37: 204-9. 2004 Circulating cytokines as markers of systemic inflammatory response in severe community-acquired pneumonia Tschaikowsky K, Hedwig-Geissing M, Schiele A, Bremer F, Schywalsky M, Schuttler J. Coincidence of pro-and anti-inflammatory responses in the early phase of severe sepsis: Longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin, C-reactive protein, and changes in T-cell subsets in septic and postoperative patients. Crit Care Med. 2002: 30: 1015-23. 2002 Coincidence of pro-and anti-inflammatory responses in the early phase of severe sepsis: Longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin, C-reactive protein, and changes in T-cell subsets in septic and postoperative patients Wolk K, Docke W, von B, V, Volk H, Sabat R. Comparison of monocyte func- tions after LPS-or IL-10-induced reorientation: importance in clinical im- munoparalysis. Pathobiology 1999: 67: 253-6. 1999 Comparison of monocyte functions after LPS-or IL-10-induced reorientation: importance in clinical immunoparalysis Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A. Compari- son of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med. 2003: 31: 1737-41. 2003 Comparison of procalcitonin and C-reactive protein as markers of sepsis Reinhart K, Brunkhorst F, Bone H, Gerlach H, Grundling M, Kreymann G, Ku- jath P, Marggraf G, Mayer K, Meier-Hellmann A, Peckelsen C, Putensen C, Quintel M, Ragaller M, Rossaint R, Stuber F, Weiler N, Welte T, Werdan K. [Diagnosis and therapy of sepsis: guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medi- cine]. Anaesthesist 2006: 55 Suppl 1: 43-56. 2006 Diagnosis and therapy of sepsis: guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine] Clec'h C, Ferriere F, Karoubi P, Fosse JP, Cupa M, Hoang P, Cohen Y. Diagnos- tic and prognostic value of procalcitonin in patients with septic shock. Crit Care Med. 2004: 32: 1166-9. 2004 Diagnostic and prognostic value of procalcitonin in patients with septic shock Harbarth S, Holeckova K, Froidevaux C, Pittet D, Ricou B, Grau GE, Vadas L, Pugin J. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am.J.Respir.Crit Care Med. 2001: 164: 396-402. 2001 Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis Clec'h C, Fosse JP, Karoubi P, Vincent F, Chouahi I, Hamza L, Cupa M, Cohen Y. Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock. Crit Care Med. 2006: 34: 102-7. 2006 Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock Moerer O, Schmid A, Hofmann M, Herklotz A, Reinhart K, Werdan K, Schnei- der H, Burchardi H. Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use. Intensive Care Med. 2002: 28: 1440-6. 2002 Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use Selberg O, Hecker H, Martin M, Klos A, Bautsch W, Kohl J. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circu- lating plasma concentrations of procalcitonin, protein complement 3a, and inter- leukin-6. Crit Care Med. 2000: 28: 2793-8. 2000 Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and inter- leukin-6 Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, Gurka D, Kumar A, Cheang M. Duration of hypotension before initiation of effective antimicrobial therapy is the critical de- terminant of survival in human septic shock. Crit Care Med. 2006: 34: 1589-96. 2006 Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M, Muller B. Effect of procalcitonin-guided treatment on antibiotic use and out- come in lower respiratory tract infections: cluster-randomised, single-blinded in- tervention trial. Lancet. 2004: 363: 600-7. 2004 Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial Brunkhorst FM. [Epidemiology, economy and practice --results of the German study on prevalence by the competence network sepsis (SepNet)]. Anasthesi- ol.Intensivmed.Notfallmed.Schmerzther. 2006: 41: 43-4. 2006 Epidemiology, economy and practice --results of the German study on prevalence by the competence network sepsis (SepNet) Brun-Buisson C, Meshaka P, Pinton P, Vallet B. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med. 2004: 30: 580-8. 2004 EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units Calandra T, Gerain J, Heumann D, Baumgartner JD, Glauser MP. High circulat- ing levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. The Swiss-Dutch J5 Im- munoglobulin Study Group. Am J Med. 1991: 91: 23-9. 1991 High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. The Swiss-Dutch J5 Immunoglobulin Study Group Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High se- rum procalcitonin concentrations in patients with sepsis and infection. Lancet. 1993: 341: 515-8. 1993 High serum procalcitonin concentrations in patients with sepsis and infection Herzum I EKRHWH. HLA-DR monitoring of septic patients: the preanalytical issue. Clin Chem. 2005: S6: A75. 2005 HLA-DR monitoring of septic patients: the preanalytical issue Hoflich C, Volk HD. Immunomodulation in sepsis. Chirurg 2002: 73: 1100-4. 2002 Immunomodulation in sepsis Garnacho-Montero J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez- Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C. Impact of adequate empirical anti- biotic therapy on the outcome of patients admitted to the intensive care unit with sepsis. Crit Care Med. 2003: 31: 2742-51. 2003 Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis Karlsson S, Varpula M, Ruokonen E, Pettila V, Parviainen I, la-Kokko TI, Kolho E, Rintala EM. Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study. Intensive Care Med. 2007: 33: 435-43. 2007 Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study Hack CE, De Groot ER, Felt-Bersma RJ, Nuijens JH, Strack Van Schijndel RJ, Eerenberg-Belmer AJ, Thijs LG, Aarden LA. Increased plasma levels of inter- leukin-6 in sepsis. Blood. 1989: 74: 1704-10. 1989 Increased plasma levels of inter- leukin-6 in sepsis Meisner M, Muller V, Khakpour Z, Toegel E, Redl H. Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model. Shock 2003: 19: 187-90. 2003 Induction of procalcitonin and proinflammatory cytokines in an anhepatic baboon endotoxin shock model Song M, Kellum JA. Interleukin-6. Crit Care Med. 2005: 33: S463-S465. 2005 Interleukin-6. Crit Care Med Perry SE, Mostafa SM, Wenstone R, Shenkin A, McLaughlin PJ. Is low mono- cyte HLA-DR expression helpful to predict outcome in severe sepsis? Intensive Care Med. 2003: 29: 1245-52. 2003 Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis? Intensive Care Med Fumeaux T, Pugin J. Is the measurement of monocytes HLA-DR expression useful in patients with sepsis? Intensive Care Med. 2006: 32: 1106-8. 2006 Is the measurement of monocytes HLA-DR expression useful in patients with sepsis? Intensive Care Med St. Martinus-Hospital Olpe (Krankenpflege) Schulbildung 1991 -2000 1991 Martinus-Hospital Olpe (Krankenpflege) Schulbildung Docke WD, Hoflich C, Davis KA, Rottgers K, Meisel C, Kiefer P, Weber SU, Hedwig-Geissing M, Kreuzfelder E, Tschentscher P, Nebe T, Engel A, Mon- neret G, Spittler A, Schmolke K, Reinke P, Volk HD, Kunz D. Monitoring tem- porary immunodepression by flow cytometric measurement of monocytic HLA- DR expression: a multicenter standardized study. Clin Chem. 2005: 51: 2341-7. 2005 Monitoring temporary immunodepression by flow cytometric measurement of monocytic HLA- DR expression: a multicenter standardized study Hershman MJ, Cheadle WG, Wellhausen SR, Davidson PF, Polk HC, Jr. Mono- cyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br.J.Surg. 1990: 77: 204-7. 1990 Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient Aikawa N, Fujishima S, Endo S, Sekine I, Kogawa K, Yamamoto Y, Kushimoto S, Yukioka H, Kato N, Totsuka K, Kikuchi K, Ikeda T, Ikeda K, Harada K, Sa- tomura S. Multicenter prospective study of procalcitonin as an indicator of sep- sis. J Infect.Chemother. 2005: 11: 152-9. 2005 Multicenter prospective study of procalcitonin as an indicator of sepsis Oberhoffer M, Vogelsang H, Russwurm S, Hartung T, Reinhart K. Outcome prediction by traditional and new markers of inflammation in patients with sep- sis. Clin.Chem.Lab Med. 1999: 37: 363-8. 1999 Outcome prediction by traditional and new markers of inflammation in patients with sepsis Monneret G, Lepape A, Voirin N, Bohe J, Venet F, Debard AL, Thizy H, Bien- venu J, Gueyffier F, Vanhems P. Persisting low monocyte human leukocyte an- tigen-DR expression predicts mortality in septic shock. Intensive Care Med. 2006: .. 2006 Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock Lee YJ, Park CH, Yun JW, Lee YS. Predictive comparisons of procalcitonin (PCT) level, arterial ketone body ratio (AKBR), APACHE III score and multiple organ dysfunction score (MODS) in systemic inflammatory response syndrome (SIRS). Yonsei Med J. 2004: 45: 29-37. 2004 Predictive comparisons of procalcitonin (PCT) level, arterial ketone body ratio (AKBR), APACHE III score and multiple organ dysfunction score (MODS) in systemic inflammatory response syndrome (SIRS) Hynninen M, Pettila V, Takkunen O, Orko R, Jansson SE, Kuusela P, Renkonen R, Valtonen M. Predictive value of monocyte histocompatibility leukocyte anti- gen-DR expression and plasma interleukin-4 and -10 levels in critically ill pa- tients with sepsis. Shock 2003: 20: 1-4. 2003 Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and -10 levels in critically ill patients with sepsis Oberhoffer M, Stonans I, Russwurm S, Stonane E, Vogelsang H, Junker U, Jager L, Reinhart K. Procalcitonin expression in human peripheral blood mono- nuclear cells and its modulation by lipopolysaccharides and sepsis-related cyto- kines in vitro. J.Lab Clin Med. 1999: 134: 49-55. 1999 Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospi- talization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003*. Crit Care Med. 2007. 1993 Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from Oda S, Hirasawa H, Shiga H, Nakanishi K, Matsuda K, Nakamua M. Sequential measurement of IL-6 blood levels in patients with systemic inflammatory re- sponse syndrome (SIRS)/sepsis. Cytokine 2005: 29: 169-75. 2005 Sequential measurement of IL-6 blood levels in patients with systemic inflammatory response syndrome (SIRS)/sepsis American College of Chest Physicians/Society of Critical Care Medicine Con- sensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992: 20: 864-74. 1992 Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Marshall JC, Maier RV, Jimenez M, Dellinger EP. Source control in the man- agement of severe sepsis and septic shock: an evidence-based review. Crit Care Med. 2004: 32: S513-S526. 2004 Source control in the management of severe sepsis and septic shock: an evidence-based review Monneret G, Finck ME, Venet F, Debard AL, Bohe J, Bienvenu J, Lepape A. The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration. Immu- nol.Lett. 2004: 95: 193-8. 2004 The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration Rau B, Steinbach G, Baumgart K, Gansauge F, Grunert A, Beger HG. The clini- cal value of procalcitonin in the prediction of infected necrois in acute pancreati- tis. Intensive Care Med. 2000: 26 Suppl 2: S159-S164. 2000 The clinical value of procalcitonin in the prediction of infected necrois in acute pancreatitis Budelmann G. [Hugo Schottmuller, 1867-1936. The problem of sepsis]. Inter- nist (Berl) 1969: 10: 92-101. 1969 The problem of sepsis Vincent JL, Moreno R, Takala J, Willatts S, De MA, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996: 22: 707-10. 1996 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Haveman JW, Muller Kobold AC, Tervaert JW, van den Berg AP, Tulleken JE, Kallenberg CG, The TH. The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment. Neth.J.Med. 1999: 55: 132-41. 1999 The TH. The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med. 2003: 31: 2332-8. 2003 Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland Damas P, Ledoux D, Nys M, Vrindts Y, De Groote D, Franchimont P, Lamy M. Cytokine serum level during severe sepsis in human IL-6 as a marker of sever- ity. Ann.Surg. 1992: 215: 356-62. 1992 Cytokine serum level during severe sepsis in human IL-6 as a marker of severity Lekkou A, Karakantza M, Mouzaki A, Kalfarentzos F, Gogos CA. Cytokine production and monocyte HLA-DR expression as predictors of outcome for pa- tients with community-acquired severe infections. Clin.Diagn.Lab Immunol. 2004: 11: 161-7. 2004 Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections 2011-09-13 http://dx.doi.org/10.17192/z2011.0548 opus:3853 ths PD Dr. Max M. Max, M. (PD Dr.) Schumann, Florian Schumann Florian Philipps-Universität Marburg
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