Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

Craan, Tobias Friedrich

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

In recent years, fragment screening has become a popular approach to identify new lead structures. Fragments are usually defined by the Astex ‘rule of three’ (RO3). Surface Plasmon Resonance (SPR), Nuclear Magnetic Resonance spectroscopy (NMR), biochemical assays and X-ray crystallography are effici...

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Opis bibliograficzny
1. autor:	Craan, Tobias Friedrich
Kolejni autorzy:	Klebe, Gerhard (Prof. Dr.) (Promotor doktoranta)
Format:	Dissertation
Język:	angielski
Wydane:	Philipps-Universität Marburg 2011
Hasła przedmiotowe:	FBLD Fragment Naturwissenschaften Fragmentbasierte Leitstrukturentwicklung Fragmentbibliotek Fragment library Natural sciences & mathematics
Dostęp online:	PDF pełnotekstowe
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!

Fragment based Drug Discovery; Design and Validation of a Fragment Library; Computer-based Fragment Screening and Fragment-to-Lead Expansion

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