Towards Improved Aldose Reductase Inhibitors - Structural and Thermodynamic Investigation of Mutant and Wild Type Aldose Reductase Inhibitor Complexes

Towards Improved Aldose Reductase Inhibitors - Structural and Thermodynamic Investigation of Mutant and Wild Type Aldose Reductase Inhibitor Complexes

Rational drug design for flexible proteins like human aldose reductase comprises special challenges to find novel lead compounds or to improve known inhibitors. In this thesis, diverse aspects of the complexity of such a task were investigated to find promising new lead scaffolds and enhance the aff...

Olles dieđut

Furkejuvvon:
Bibliográfalaš dieđut
Váldodahkki: Koch, Cornelia
Eará dahkkit: Klebe, Gerhard (Prof.) (BetreuerIn (Doktorarbeit))
Materiálatiipa: Dissertation
Giella:eaŋgalasgiella
Almmustuhtton: Philipps-Universität Marburg 2011
Fáttát:
Röntgenstrukturanalyse
drug design
diabetes
X-ray
Chemie
Aldosereduktase
Wirkstoff-Rezeptor-Bindung
aldose reductase
Inhibitor
Isothermal titration calorimetry
Isothermale Titrationskalorimetrie
Diabetes mellitus
Wirkstoffdesign
Kalorimetrie
Chemistry & allied sciences
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oažžasuvvan:
Hildobáiki: urn:nbn:de:hebis:04-z2011-04163
Almmustuhttinbeaivi: 2011-06-28
Datum der Annahme: 2011-05-31
Downloads: 73 (2024), 82 (2023), 52 (2022), 17 (2021), 29 (2020), 19 (2019), 28 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Liŋka materiálii: https://archiv.ub.uni-marburg.de/diss/z2011/0416
https://doi.org/10.17192/z2011.0416

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