Die Bedeutung der Surfactantproteine SP-A und SP-D bei der Modulation des Entzündungsprozesses im Rahmen des chronischen Asthma bronchiale

Asthma bronchiale bezeichnet eine chronische Erkrankung des Respirationstraktes, die durch eine Entzündungsreaktion und bronchiale Hyperreagibilität gegenüber verschiedenen endogenen und exogenen Noxen charakterisiert ist. Durch die verstärkte Expression proinflammatorischer Zytokine kommt es zu ein...

Full description

Saved in:
Bibliographic Details
Main Author: Diogo, Isabell
Contributors: Müller, Bernd (Prof.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2011
Innere Medizin
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!

1. Zhu Z: IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2002; 168:2953–2962.

2. Schmitt E, Van Brandwijk R, Fischer HG, Rude E: Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors. Eur J Immunol. 1990 Aug;20(8):1709-15.

3. Wan H: Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 2003;131:953–964.

4. Tavernier J, Devos R, Cornelis S, Tuypens T, Van der, Heyden J, Fiers W, Plaetinck G: A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. Cell 1991, 66:1175-1184.

5. Cooperative interaction between chemokines and IL-13. J Allergy Clin Immunol 2003; 111:227–242.

6. 13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res 2002, 62: 1103-1109

7. Whitehead GS, Walker JK, Berman KG, Foster WM, Schwartz DA: Allergen- induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol . 2003; 285(1):L32-42.

8. Jr. RA, Beers MF: Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Am J Respir Cell Mol Biol 2001; 25:45-50

9. Association with expression of VCAM-1. J Immunol 1992, 148: 1086-1092

10. Ebina M, Takahashi T, Chiba R, Motomiya M: Cellular Hypertrophy and Hyperplasia of Airway Smooth Muscle underlying Bronchial Asthma. Am. Rev Respir.

11. Zhou Y: Characterization of a calciumactivated chloride channel as a shared target of Th2 cytokine pathways and its potential involvement in asthma. Am J Respir Cell Mol Biol 2001; 25:486–491.

12. Schuh JM, Blease K, Kunkel SL, Hogaboam CM: Chemokines and cytokines. axis and allies in asthma and allergy. Cytokine Growth Factor Rev 2003;14:503–510.

13. Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E; ALEX Study Team: Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001

14. van Rozendaal BA, v.G.L., Haagsman HP: Localization and functions of SP-A and SP-D at mucosal surfaces. Pediatr Pathol Mol Med 2001; 20: 319-339

15. Strachan DP: Hay fever, hygiene, and household size. BMJ. 1989 Nov 18;299(6710):1259-60.

16. HLA-DR and ICAM I expression on bronchial epithelial cells in asthma and chronic bronchitis. Am. Rev. Respir. Dis. 1993; 148:689-694.

17. Hyperreactive Site in the Airway Tree of Asthmatik Patients revealed by Thickening of Bronchial Muscles. Am. Rev. Respir. Dis. Cell Mol. Biol. 1990;141:1327-1332.

18. Walsh GM, Hartnell A, Wardlaw AJ, Kurihara K, Sanderson, CJ, Kay AB: IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyteintegrin (CD11/18)-dependent manner. Immunol 1990, 71:258-265.

19. Wang JY, Shieh CC, Yu CK, Lei HY, Reid KB: Inhibitory effects of pulmonary surfactant proteins A and D on allergen-induced lymphocyte proliferation and histamine release in children with asthma. Am J Respir Crit Care Med 1998;158:510-518.

20. Reid KB: Interactions of surfactant protein D with pathogens, allergens and phagocytes.

21. Vaandrager AB, van Golde LM: Lung surfactant proteins A and D in innate immune Defense. Biol Neonate 2000; 77 (suppl 1): 9-13

22. Sandford AJ, Chagani T, Zhu S, Weir TD, Bai TR, Spinelli JJ, Fitzgerald JM, Behbehani NA, Tan WC, Pare PD: Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):135-40.

23. Evans DJ, Lindsay MA, O'Connor BJ, Barnes PJ: Priming of circulating human eosinophils following late response to allergen challenge. Eur. Respir. J. 9, 703-708 (1996).

24. Rothenberg ME: Eosinophilia. [Review] [72 refs]. New England Journal of Medicine 1998, 338(22):1592-600

25. Takeda K, Miyahara N, Rha YH, Taube C, Yang ES, Joetham A, Kodama T, Balhorn AM, Dakhma A, Duez C, Evans AJ, Voelker DR, Gelfend EW: Surfactant protein D regulates airway function and allergic inflammation through modulation of makrophage function. Am J Respir Crit Care Med 2003; 168:783-789

26. White MK, Strayer DS: Survival signaling in type II pneumocytes activated by surfactant protein-A. Exp Cell Res 2002;280(2):270-279.

27. Graber P, Gretener D, Herren S, Aubry JP, Elson G, Poudrier J: The distribution of IL-13 receptor alpha 1 expression on B cells, T cells, and monocytes and its regulation by IL-13 and IL-4. Eur J Immunol 1998;28:4286–4298.

28. Williams CM, Galli SJ: The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000; 105:847-59.

29. Varner AE: The increase in allergic respiratory disease: survival of the fittest? Chest 2002;121:1308-16

30. Grell M, Douni E, Wajant H, Lohden M, Clauss M, Maxeiner B, Georgopoulos S, Lesslauer W, Kollias G, Pfizenmaier K, Scheurich P: The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 1995, 83:793-802.

31. Wajant H, Pfizenmaier K, Scheurich P: Tumor necrosis factor signaling. Cell Death. Differ., 2003, 10:45-65.

32. Thomas PS: Tumour nekrosis factor-α: The role of this multifunktional cytokine in asthma. Immunol Cell Biol 2001;79: 132-140

33. Fehrenbach H: Alveolar epithelial type II cell: defender of the alveolus revisited.

34. Saunders MA, Mitchell JA, Seldon PM, Yacoub JH, Barnes PJ, Giembycz MA, Belvisi MG: Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone. Br. J. Pharmacol. 1997;120:545-6.

35. Gao PS, Mao XQ, Roberts MH, Arinobu Y, Akaiwa M, Enomoto T, Dake Y, Kawai M, Sasaki S, Hamasaki N, Izuhara K, Shirakawa T, Hopkin JM: Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma. J Med Genet. 2000 May;37(5):380-2.

36. Wert SE, Yoshida M, LeVine AM, Ikegami M, Jones T, Ross GF, Fisher JH, Korfhagen TR, Whitsett JA: Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci U.S.A. 2000; 97:5972-5977

37. Williams CM, Galli SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000;192:455-62.

38. Zheng T: Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase and cathepsin-dependent emphysema. J Clin Invest 2000; 106:1081–1093.