Progressive Splenomegalie und Makrozytose bei KCa3.1-defizienten Mäusen: Die physiologische Bedeutung des Gardos-Kanals im Erythrozyten

Der Gardos-Kanal (KCa3.1) vermittelt den Ca2+-abhängigen Ausstrom von K+ und Cl- (den Gardos-Effekt) im Erythrozyten. Hierdurch kommt es zu einer Hyperpolarisation der Zellmembran und einem osmotisch bedingten Schrumpfen der Zelle. Diesem Ca2+-aktivierten K+-Kanal wird daher eine entscheidende Rol...

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Main Author: Paschen, Steffen
Contributors: Köhler, Ralf (Dr.) (Thesis advisor)
Format: Dissertation
Published: Philipps-Universität Marburg 2010
Innere Medizin
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