Synthesis and Analytics of Rigidified Peptide Architectures: Neuropeptide Y Dipeptide Scan, Ring-Chain-Equilibria of Iminopeptides, Thiazole Amino Acids for Thiopeptide Antibiotics

Synthesis and Analytics of Rigidified Peptide Architectures: Neuropeptide Y Dipeptide Scan, Ring-Chain-Equilibria of Iminopeptides, Thiazole Amino Acids for Thiopeptide Antibiotics

The architectures (three-dimensional shapes) of peptides determine their respective biological functions. Therefore, the correct alignment of functionalities in a structure by constraining the flexibility is a key process in evolution as well as in medicinal chemistry in order to increase binding af...

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Détails bibliographiques
Auteur principal: Enck, Sebastian
Autres auteurs: Geyer, Armin (Prof. Dr.) (Directeur de thèse)
Format: Dissertation
Langue:anglais
Publié: Philipps-Universität Marburg 2010
Sujets:
Entropiebilanz
Organic synthesis
Thiazoles
Macrocyclization
NMR-Spektroskopie
Macrocyclisierung
NMR spectroscopy
Organische Synthese
Vororientierung
Scanning
Thiazole
Chemie
Peptide antibiotics
Peptidantibiotikum
Chemistry & allied sciences
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