Neue Ansätze zur Entwicklung eines Ganzzellbiosensors

Unter Verwendung der Oberflächenplasmonresonanz (SPR) wurden unterschiedliche Modellapplikationen etabliert. Es wurden verschiedene Zuckeroberflächen erzeugt und durch ein Lektin-Screening charakterisiert. Das Bindungsverhalten derartiger Oberflächen wurde daraufhin an NCI-H125- sowie an Lewis Lung-...

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Main Author: Vornholt, Wolfgang
Contributors: Keusgen, Michael (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2010
Pharmazeutische Chemie
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1. Schlegel, H.G. und Zaborosch, C.: Allgemeine Mikrobiologie. Stuttgart: Thieme Verlag, 7. Auflage, 1992


2. Green, R.J., Frazier, R.A., Shakesheff, K.M., Davies, M.C., Roberts C.J. und Tendler, S.J.B.: " Surface plasmon resonance analysis of dynamic biological interactions with biomaterials " . Biomaterials 21 (2000), 1823-1835


3. Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K. und Kimoto, M.: " MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll- like receptor 4 " . Journal of Experimental Medicine 189 (1999), 1777-1782


4. Carney, D.N., Gazdar, A.F., Bepler, G., Guccion, J.G., Marangos, P.J., Moody, T.W., Zweig, M.H. und Minna, J.D.: " Establishment and identification of small cell cancer cell lines having classic and variant features " . Cancer Research 45 (1985), 2913-2923


5. Guilbault, G.G.: " Enzyme electrode probes " . Methods in Enzymology 137 (1988), 14-29


6. Zynio, S.A., Samoylov, A.V., Surovtseva, E.R., Mirsky, V.M. und Shirshov, Y.M.: " Bimetallic layers increase sensitivity of affinity sensors based on surface plasmon resonance " . Sensors 2 (2002), 62-70


7. Adami, M., Sartore, M., Baldini, E., Rossi, A. und Nicolini, C.: " New measuring principle for LAPS devices " . Sensors and Actuators B: Chemical 9 (1992), Nr.1, 25-31


8. Thomsen, L., Watts,B. , Cotton, D.V., Quinton, J.S. und Dastoor, P.C.: " Adsorption and orientation kinetics of self-assembled films of octadecyltrimethoxysilane on aluminium oxide surfaces " . Surface and Interface Analysis 37 (2005), 472-477


9. Keusgen, M., Schöning, M.J. und Jünger, M.: " Entwicklung eines reagenzlosen Cyanid- Biosensors auf der Basis von EIS-Strukturen " . Deutsche Patentanmeldung DE 1031296.6, (2003) 231


10. Wagner, T., Vornholt, W., Biselli, M., Keusgen, M. und Schöning, M.J.: " Towards a pharmaceutical screening system combining the light-addressable potentiometric sensor with magnetic beads " . Biosensors 2008, (2008 a ), O82


11. Ermolenko, Y.E., Yoshinobu, T., Mourzina, Y.G., Vlasov, Y.G., Schöning, M.J. und Iwasaki, H.: " Laser-scanned silicon transducer (LSST) as a multisensor system " . Sensors and Actuators B: Chemical 103 (2004), Nr.1-2, 457-462


12. Wagner, T., Vornholt, W., Werner, C.F.B., Yoshinobua, T., Miyamotoe, K., Schöning, M.J. und Keusgen, M.: " A biosensor based on a light-addressable potentiometric sensor (LAPS) and magnetic beads for pharmaceutical screening " . In Vorbereitung Vornholt, W., Seidel, N., Kissel, T. und Keusgen, M.: " Poly(ethylene carbonate) biodegradation monitored by surface plasmon resonance (SPR) " . In Vorbereitung Vorträge Vornholt, W., Hartmann, M., Mazumdar S.D. und Keusgen, M.: " Artificial pathogenic bacteria on a surface plasmon resonance (SPR) platform " . The Ninth World Congress on Biosensors, Toronto (Kanada), Mai 2006


13. Richardson, N.J., Gardner, S. und Rawson, D.M.: " A chemically mediated amperometric biosensor for monitoring eubacterial respiration " . The Journal of Applied Bacteriology 70 (1991), 422-426


14. Heiny, B.M.: " Additive Therapie mit standardisiertem Mistelextrakt reduziert die Leukopenie und verbessert die Lebensqualität von Patientinnen mit fortgeschrittenem Mammakarzinom unter palliativer Chemotherapie " . Krebsmedizin 12 (1991), 334-344


15. Levin, J. und Bang, F.B.: " A description of cellular coagulation in the limulus " . Bulletin of the Johns Hopkins Hospital 115 (1964 a ), 337-345


16. Medzhitov, R. und Janeway, C.Jr.: " Advances in immunology: innate immunity " . The New England Journal of Medicine 343 (2000), 338-344


17. Gazdar, A.F.: " Advances in the biology of non small cell lung cancer " . Chest 89 (1989), 4 Supplement, 277S-283S


18. Ainsworth, G.C., Brown, A.M. und Brownlee, G.: " 'Aerosporin', an antibiotic produced by Bacillus aerosporus Greer " . Nature 160 (1947), 263


19. Medzhitov, R., Preston-Hurlburt, P. und Janeway, C.A.Jr.: " A human homologue of the Drosophila Toll protein signals activation of adaptive immunity " . Nature 388 (1997 b ), Nr.6640, 394-397


20. Kitagawa, Y., Ameyama, M., Nakashima, K., Tamiya, E. und Karube, I.: " Amperometric alcohol sensor based on an immobilised bacteria cell membrane " . The Analyst 112 (1987), Nr.12, 1747-1749


21. Glimelius, B. und Pintar, J.E.: " Analysis of developmentally homogeneous neural crest cell populations in vitro. IV. Cell proliferation and synthesis of glycosaminoglycans " . Cell Differentiation 10 (1981), 173-182


22. Gabius, S., Kayser, K. und Gabius, H.-J.: " Analytische, immunologische und tierexperimentelle Voraussetzungen für die klinische Prüfung der auf Lektingehalt standartisierten Misteltherapie " . Deutsche Zeitschrift für Onkologie 23 (1991), 113-119


23. Horisberger, M.: " An application of ellipsometry. Assessment of polysaccharide and glycoprotein interaction with lectin at a liquid/solid interface " . Biochimica et Biophysica Acta 632 (1980), Nr.2, 298-309


24. Bagley, D.M., Broner, L.H., Silva, O. de, Cottini, M., O'Brien, K.A.F., Uttley, M. und Walker, A.P.: " An evaluation of five potential alternatives in vitro to the rabbit eye irritation test in viva " . Toxicology in Vitro 6 (1992), 275-284


25. Vang, O., Larsen, K.P. und Bøg-Hansen, T.C.: " A new quantitative and highly specific assay for lectin-binding activity " . Lectins 5 (1986), 637-646


26. Weiss, A.R.: " A new ultrafiltration unit for the removal of substances interfering with the lal-endotoxin-test " . In: Watson, S.W., Levin, J. und Nowitzky, T.J. (Hrsg.): Detection of bacterial endotoxins with the limulus amebocyte lysate test. New York: Alan R. Liss, Inc., 1987, 235-249


27. Kilpatrick, D.C.: " Animal lectins: a historical introduction and overview " . Biochimica et Biophysica Acta 1572 (2002), 187-197


28. Parkin, J. und Cohen, B.: " An overview of the immune system " . Lancet 357 (2001), 1777-1789


29. Benedict, R.G. und Langlykke, A.F.: " Antibiotic activity of Bacillus polymyxa " . The Journal of Bacteriology 54 (1947), 24-25


30. Jack, A., Weinzierl, J. und Kalb, A.: " An X-ray crystallographic study of demetallized concanavalin A " . Journal of Molecular Biology 58 (1971), 389-395


31. Elmore, S.: " Apoptosis: a review of programmed cell death " . Toxicologic Pathology 35 (2007), Nr.4, 495-516


32. Büssing, A. und Schietzel, M.: " Apoptosis-inducing properties of Viscum album L. extracts from different host trees, correlate with their content of toxic mistletoe lectins " . Anticancer Research 19 (1999), 23-28


33. Vornholt, W. und Keusgen, M.: " Artificial pathogenic bacteria for the study between surface structures and suitable targets " . DPhG (Deutsche Pharmazeutische Gesellschaft) Jahrestagung (Joint Meeting), Marburg, Oktober 2006


34. Mühlradt, P.F. und Golecki, J.R.: " Asymmetrical distribution and artifactual reorientation of lipopolysaccharide in the outer membrane bilayer of Salmonella typhimurium " .


35. Wicken, A.J. und Knox, K.W.: " Bacterial cell surface amphiphiles " . Biochimica et Biophysica Acta 604 (1980), 1-26


36. Rietschel, E.T., Kirikae, T., Schade, F.U., Mamat, U., Schmidt, G., Loppnow, H., Ulmer, A.J., Zahringer, U., Seydel, U., Di Padova, F. und et al.: " Bacterial endotoxin: molecular relationships of structure to activity and function " . The FASEB Journal 8 (1994), Nr.2, 217-225


37. Rietschel, E.T., Brade, L., Schade, U., Seydel, U., Zahringer, U., Kusumoto, S. und Brade, H.: " Bacterial endotoxins: properties and structure of biologically active domains " . In: Schrinner, E., Richmond, M.H., Seibert, G. und Schwarz, U. (Hrsg.): Surface structures of microorganisms and their interactions with the mammalian host. Weinheim: VCH Publishers, 1988, 1-41


38. Alexander, C. und Rietschel, E.T.: " Bacterial lipopolysaccharides and innate immunity " . Journal of Endotoxin Research 7 (2001), Nr.3,167-202


39. Beuth, J., Ko, H.L., Gabius, H.J., Burrichter, H., Oette, K. und Pulverer, G.: " Behavior of lymphocyte subsets and expression of activation markers in response to immunotherapy with galactoside-specific lectin from mistletoe in breast cancer patients " . The Clinical Investigator 70 (1992), 658-661


40. Sanchez, J.F., Lescar, J., Chazalet, V., Audfray, A., Gagnon, J., Alvarez, R., Breton, C., Imberty, A. und Mitchell, E.P.: " Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold " . The Journal of Biological Chemistry 281 (2006), Nr.29, 20171-20180


41. Gmeiner, J., Luderitz, O. und Westphal, O.: " Biochemical studies on lipopolysaccharides of Salmonella R mutants.6. Investigations on the structure of the lipid A component " . European Journal of Biochemistry / FEBS 7 (1969), Nr.3, 370-379


42. Grattarola, M. und Massobrio, G.: " Bioelectronics handbook: MOSFETs, biosensors and neurons " . New York: McGraw-Hill, 1998


43. Selifonova, O., Burlage, R. und Barkay, T.: " Bioluminescent sensors for detection of bioavailable Hg(ll) in the environment " . Applied and Environmental Microbiology 59 (1993), 3083-3090


44. Keusgen, M.: Biosensorische Methoden zur quantitativen Bestimmung von Cysteinsulfoxiden. Aachen: Shaker Verlag, 1999


45. Eggins, B.R.: Biosensors: an introduction. New York: John Wiley & Sons Ltd., 1996


46. Paddle, B.M.: " Biosensors for chemical and biological agents of defense interest " . Biosensors & Bioelectronics 11 (1996), 1079-1113


47. Turner, A.P.F., Karube, I. und Wilson, G.S.: Biosensors: Fundamentals and Applications. Oxford: Oxford University Press, 1987, 770-775


48. Keusgen, M.: " Biosensors: new approaches in drug discovery " . Naturwissenschaften 89 (2002), 433-444


49. Stoeva, S., Maier, T., Soler, M.H. und Voelter, W.: " Carbohydrate chains and their binding sites in mistletoe lectin I " . Polish Journal of Chemistry 73 (1999), Nr.1, 125-133


50. Kawasaki, T. und Ashwell, G.: " Carbohydrate structure of glycopeptides isolated from an hepatic membrane-binding protein specific for asialoglycoproteins " . The Journal of Biological Chemistry 251 (1976), 5292-5299


51. Wright, S.D.: " CD14 and innate recognition of bacteria " . Journal of Immunology 155 (1995), 6-8


52. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. und Mathison, J.C.: " CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein " . Science 249 (1990), 1431-1433


53. Backman, P. und Wadsö, I.: " Cell growth experiments using a microcalorimetric vessel equipped with oxygen and pH electrodes " . Journal of Biochemical and Biophysical Methods 23 (1991), 283-293


54. Karahashi, H. und Amano, F.: " Changes of caspase activities involved in apoptosis of a macrophage-like cell line J774.1/JA-4 treated with lipopolysaccharide (LPS) and cycloheximide " . Biological & Pharmaceutical Bulletin 23 (2000 a ), Nr.2, 140-144


55. Eck, J., Langer, M., Möckel, B., Witthohn, K., Zinke, H. und Lentzen, H.: " Characterization of recombinant and plant-derived mistletoe lectin and their B-chain " . European Journal of Biochemistry 265 (1999 b ), 788-797


56. Bakowsky, U., Rettig, W., Bendas, G., Vogel, J., Bakowsky, H., Harnagea, C. und Rothe, U.: " Characterization of the interactions between various hexadecylmannoside- phospholipid model membranes with the lectin concanavalin A " . Chemical Physics 2 (2000), 4609-4614


57. Gauglitz, G., Brecht, A., Kraus, G. und Nahm, W.: " Chemical and biochemical sensors based on interferometry at thin layers " . Sensors and Actuators B 11 (1993), 21-27


58. Imoto, M., Kusumoto, S., Shiba, T., Rietschel, E.T., Galones, C. und Lüderitz, O.: " Chemical structure of Escherichia coli lipid A " . Tetrahedron Letters 26 (1985), 907-908


59. Westphal, O. und Lüderitz, O.: " Chemische Erforschung von Lipopolysacchariden Gram-negativer Bakterien " . Angewandte Chemie 66 (1954), 407-417


60. Hirayama, C. und Sakata, M.: " Chromatographic removal of endotoxin from protein solutions by polymer particles " . Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 781 (2002), 419-432


61. Eck, J., Langer, M., Möckel, B., Baur, A., Rothe, M., Zinke, H. und Lentzen, H.: " Cloning of the mistletoe lectin gene and characterization of the recombinant A-chain " . European Journal of Biochemistry 264 (1999 a ), 775-784


62. Kosenko, L.V.: " Comparative characteristics of carbohydrate binding by lectins from broad bean, pea, common vetch and lentil seeds " . Russian Journal of Plant Physiology 49 (2002), Nr.5, 718-724


63. Soler, M.H., Stoeva, S., Schwamborn, C., Wilhelm, S., Stiefel, T. und Voelter, W.: " Complete amino acid sequence of the A chain of mistletoe lectin I " . FEBS Letters 399 (1996), 153-157


64. Kulkarni, G.V. und McCulloch, C.A.C.: " Concanavalin A induced apoptosis in fibroblasts: The role of cell surface carbohydrates in lectin mediated cytotoxicity " . Journal of Cellular Physiology 165 (1995), 119-133


65. Niwa, H., Tonevitsky, A.G., Agapov, I.I., Sward, S., Pfüller, U. und Palmer, R.A.: " Crystal structure at 3Å of mistletoe lectin I, a dimeric type-II ribosome-inactivating protein, complexed with galactose " . European Journal of Biochemistry 270 (2003), 2739-2749


66. Krauspenhaar, R., Eschenburg, S., Perbandt, M., Kornilov, V., Konareva, N., Mikailova, I., Stoeva, S., Wacker, R., Maier, T., Singh, T., Mikhailov, A., Voelter, W. und Betzel, C.: " Crystal structure of mistletoe lectin I from Viscum album " . Biochemical and Biophysical Research Communications 257 (1999), 418-424


67. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. und Akira, S.: " Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product " . Journal of Immunology 162 (1999), 3749-3752


68. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Huffel, C.V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. und Beutler, B.: " Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene " . Science 282 (1998), 2085-2088


69. Edwards, P.R. und Leatherbarrow, R.J.: " Determination of association rate constants by an optical biosensor using initial rate analysis " . Analytical Biochemistry 246 (1997), 1-6


70. Ziska, P. und Franz, H.: " Determination of lectin content in commercial mistletoe preparations for cancer therapy using the ELISA technique " . Lectins 4 (1985), 473-480


71. Li, N., Endo, H., Hayashi, T., Fujii, T., Takal, R. und Watanabe, E.: " Development of a trimethylamine gas biosensor system " . Biosensors & Bioelectronics 9 (1994), 593-599


72. Grimm, S.: " Die Apoptose: Programmierter Zelltod " . Chemie in unserer Zeit 37 (2003), Nr.3, 172-178


73. Gabius, H.-J. und Gabius, S.: " Die Misteltherapie auf dem naturwissenschaftlichen Prüfstand " . Pharmazeutische Zeitung 139 (1994), 9-16


74. Bangham, A.D., Standish, M.M. und Watkins, J.C.: " Diffusion of univalent ions across the lamellae of swollen phospholipids " . Journal of Molecular Biology 13 (1965), 238-252


75. Allen, T.M. und Everest, J.M.: " Effect of liposome size and drug release properties on pharmacokinetics of encapsulated drug in rats " . The Journal of Pharmacology and Experimental Therapeutics 226 (1983), 539-544


76. Takemoto, Y., Nakatani, T., Sugimura, K., Yoshimura, R. und Tsuchida, K.: " Endotoxin adsorption of various dialysis membranes: In vitro study " . Artificial Organs 27 (2003), 1134-1137


77. Rylander, R.: " Endotoxin in the environment – exposure and effects " . Journal of Endotoxin Research 8 (2002), Nr.4, 241-252


78. Qureshi, S.T., Lariviere, L., Leveque, G., Clermont, S., Moore, K.J., Gros, P. und Malo, D.: " Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) " . Journal of Experimental Medicine 189 (1999), 615-625


79. Chihara, S., Tobita, T., Yahata, M., Ito, A. und Koyana, Y.: " Enzymatic degradation of colistin isolation and identification of α-N-acetyl α,γ -diaminobutyric acid and colistin nonapeptide " . Agricultural and Biological Chemistry 37 (1973), 2455-2463


80. Bertram, J.S. und Janik, P.: " Establishment of a cloned line of Lewis Lung Carcinoma cells adapted to cell culture " . Cancer Letters 11 (1980), 63-73


81. Otto, A.: " Excitation of nonradiative surface plasma waves in silver by the method of frustrated total reflection " . Zeitschrift für Physik 216 (1968), Nr.4, 398-410


82. Forsberg, K., Bergh, J. und Westermark, B.: " Expression of functional PDGF ß receptors in a human large cell lung carcinoma cell line " . International Journal of Cancer 53 (1993), 556-560


83. Gabius, H.-J., Gabius, S., Joshi, S.S., Koch, B., Schröder, M., Manzke, W.M. und Westerhausen, M.: " From iII-defined extracts to the immunomodulatory lectin: Will there be a reason for oncological application of Mistletoe? " Planta Medica 60 (1993), 2-7


84. Patterson, S. und Isaacson, R.E.: " Genetics and pathogenesis of Salmonella " . In: Torrence, M.E., Isaacson, R.E.: Microbial food safety in animal agriculture, current topics. Iowa State: University Press, 2003


85. Wilkins, E. und Atanasov, P.: " Glucose monitoring: state of the art and future possibilities " . Medical Engineering & Physics 18 (1996), 273–288


86. Dwek, R.A.: " Glycobiology: Toward understanding the function of sugars " . Chemical Reviews 96 (1996), Nr.2, 683-720


87. Glick, M.C., Schlesinger, H. und Hummeler, K.: " Glycopeptides from the surgace of human neuroblastoma cells " . Cancer Research 36 (1976), 4520-4524


88. Toole, B.P.: " Glycosaminoglycans in morphogenesis " In: Hay, E.D.: Cell Biology of Extracellular Matrix. New York: Plenum, 1981


89. Wilkinson, S.G.: " Gram-negative bacteria " . In: Ratledge, C. und Wilkinson, S.G.


90. Brower, M., Carney, D.N., Oie, H.K., Gazdar, A.F. und Minna, J.D.: " Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum free defined medium " . Cancer Research 46 (1986), 798-806


91. Bleicher, M.: Halbleiter-Optoelektronik. Heidelberg: Hüthig Verlag, 1986


92. Kloock, J.P.: Herstellung und Charakterisierung von Sensormembranen aus Chalkogenidglasschichten für den Einsatz als Schwermetallsensoren in Flüssigkeiten.


93. Rivest, S., Lacroix, S., Vallieres, L., Nadeau, S., Zhang, J. und Laflamme, N.: " How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli " . Proceedings of the Society for Experimental Biology and Medicine 223 (2000), Nr.1, 22-38


94. Tobias, P.S., Soldau, K. und Ulevitch, R.J.: " Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein " . The Journal of Biological Chemistry 264 (1989), Nr.18, 10867-10871


95. Milka, P., Krest, I. und Keusgen, M.: " Immobilization of alliinase on porous aluminium oxide " . Biotechnology and Bioengineering 69 (2000), Nr.3, 344-348


96. Hajto, T., Hostanska, K., Frei, K., Rordorf, C. und Gabius, H.-J.: " Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extracts " . Cancer Research 50 (1990), Nr.11, 3322-3326


97. Storm, G., Roerdink, F.H., Steerenberg, P.A., de Jong, W.H. und Crommelin, D.J.: " Influence of lipid composition on the antitumor activity exerted by doxorubicin- containing liposomes in a rat solid tumor model " . Cancer Research 47 (1987), 3366-3372


98. Franz, H.: " Inhaltsstoffe der Mistel (Viscum album L.) als potentielle Arzneimittel " . Pharmazie 40 (1985), 97-104


99. Beutler, B. und Rietschel, E.T.: " Innate immune sensing and its roots: the story of endotoxin " . Nature Reviews Immunology 3 (2003), Nr.2, 169-176


100. Medzhitov, R. und Janeway, C.A.Jr.: " Innate immunity: the virtues of a nonclonal system of recognition " . Cell 91 (1997 a ), Nr.3, 295-298


101. Banks-Schlegel, S.P., Gazdar, A.F. und Harris, C.C.: " Intermediate filament and cross- linked envelope expression in human lung tumor cell lines " . Cancer Research 45 (1985), 1187-1197


102. Brousseau, J.-L., Vidon, S. und Leblanc, R.M.: " Investigation of the chemical nature of two-dimensional polymerized octadecyltrimethoxysilane Langmuir films by inelastic electron tunneling spectroscopy " . Journal of Chemical Physics 108 (1998), Nr.17, 7391-7396


103. Olsnes, S., Stirpe, F., Sandvig, K. und Pihl, A.: " Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (Mistletoe) " . The Journal of Biological Chemistry 257 (1982), Nr.22, 13263-13270


104. Warburg O. und Christian W.: " Isolierung und Charakterisierung des Gärungsferments Enolase " . Biochemische. Zeitschrift 310 (1942), 384–421


105. Vornholt, W. und Keusgen, M.: " Künstliche Bakterien als Modellsystem zur Untersuchung spezifischer Interaktionen zwischen Oberflächenstrukturen und passenden Zielstrukturen " . 5. Deutsches BioSensor Symposium (DBS 2007), Bochum, März 2007


106. Lis, H. und Sharon, N.: " Lectin-carbohydrate interactions " . Current Opinion in Structural Biology 1 (1991), 741-749


107. Sharon, N. und Lis, H.: " Lectins as cell recognition molecules " . Science 246 (1989), Nr. 4927, 227-234


108. Khan, F., Khan, R., Sherwani, A., Mohmood, S. und Azfer, A.: " Lectins as markers for blood grouping " . Medical Science Monitor 8 (2002), Nr.12, 293-300


109. Montreuil, J., Debray, H., Debeire, P. und Delannoy, P.: " Lectins as oligosaccharide receptors " . In: Popper, H., Reutter, W., Gudat, F. und Köttgen, E. (Hrsg.): Structural carbohydrates in the liver. Boston: MTP Press Limited,1983, 239-258


110. Lotan, R. und Raz, A.: " Lectins in cancer cells " . Annals of the New York Academy of Sciences 551 (1988), 385-398


111. Lis, H. und Sharon, N.: " Lectins in higher plants " . In: Marcus, A. (Hrsg): The Biochemistry of Plants: A Comprehensive Treatise, Volume 6 (Proteins and Nucleic Acids). New York: Academic Press, 1981, 371-447


112. Wagner, T.: Lichtadressierbare potentiometrische Sensoren für den Einsatz in der Pharmazie. Marburg, Philipps-Universität Marburg, Fachbereich Pharmazie, Dissertation, 2008


113. Lee, R.T., Gabius, H.-J. und Lee, Y.C.: " Ligand binding characteristics of the major mistletoe lectin " . The Journal of Biological Chemistry 267 (1992), Nr.33, 23722-23727


114. Hafeman, D.G., Parce, J.W. und McConnell, H.M.: " Light-addressable potentiometric sensor for biochemical systems " . Science 240 (1988), 1182-1185


115. Karahashi, H. und Amano, F.: " Lipopolysaccharide (LPS)-induced cell death of C3H mouse peritoneal macrophages in the presence of cycloheximide: different susceptibilities of C3H/HeN and C3H/HeJ " . Journal of Endotoxin Research 6 (2000 b ), Nr.1, 33-39


116. Novogrodsky, A. und Katchalski, E.: " Lymphocyte transformation induced by concanavalin A and its reversion by methyl-alpha-D-mannopyranoside " . Biochimica and Biophysica Acta 228 (1971), Nr.2, 579-583


117. Ozawa, T.: " Mechanism of somatic mitochondrial DNA mutations associated with age and diseases " . Biochimica et Biophysica Acta 1271 (1995), Nr.1, 177-189


118. Karube, I., Sode, K., Suzuki, M. und Nakahara, T.: " Microbial sensor for preliminary screening of mutagens utilizing a phage induction test " . Analytical Chemistry 61 (1989), 2388-2391


119. Bousse, L., McReynolds, R.J., Kirk, G., Dawes, T., Lam, P., Bemiss, W.R. und Parce, J.W.: " Micromachined multichannel systems for the measurement of cellular metabolism " . Sensors and Actuators. B, Chemical 20 (1994), 145-150


120. Burghardt, F.: Mikrobiologische Diagnostik. Stuttgart: Thieme Verlag, 1992


121. Stauder, H. und Kreuser, E.-D.: " Mistletoe extracts standardised in terms of mistletoe lectins (ML I) in oncology: Current state of clinical research " . Onkologie 25 (2002), 374-380


122. Heiny, B.M. und Beuth, J.: " Mistletoe extract standardized for the galactoside-specific lectin (ML-1) induces β-endorphin release and immunopotentiation in breast cancer patients " . Anticancer Research 14 (1994), 1339-1342


123. Agapov, I.I., Tonevitsky, A.G., Maluchenko, N.V., Moysenovich, M.M., Bulah, Y.S. und Kirpichnikov, M.P.: " Mistletoe lectin A-chain unfolds during the intracellular transport " . FEBS Letters 464 (1999 a ), 63-66


124. Agapov, I.I., Tonevitsky, A.G., Moysenovich, M.M., Maluchenko, N.V., Weyhenmeyer, R. und Kirpichnikov, M.P.: " Mistletoe lectin dissociates into catalytic and binding subunits before translocation across the membrane to the cytoplasm " . FEBS Letters 452 (1999 b ), 211-214


125. Piehler, J.: Modifizierung von Oberflächen für die thermodynamische und kinetische Charakterisierung biomolekularer Erkennung mit optischen Transducern. Tübingen, Eberhard-Karls-Universität Tübingen, Dissertation, 1997


126. Hajto, T., Hostanska, K. und Gabius, H.-J.: " Modulatory potency of the β-galactoside- specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients " . Cancer Research 49 (1989), Nr.17, 4803-4808


127. Nikitin, P., Goshkov, B., Valeiko, M. und Nikitin, S.: " Multichannel optical biosensors for label free high-throughput screening " . SPIE Proceedings 4578 (2001), 126-135


128. Khoursandi, S.: Nachweis und Reinigung der Myristoyl-CoA: Protein N- Myristoyltransferase (NMT) aus Trypanosoma brucei brucei und Herstellung monoklonaler Antikörper gegen trypanosomale NMT und GPI-spezifische Phospholipase C (GPI-PLC). Bonn, Universität, Dissertation, 2000


129. Hartmann, M.: Neue Ansätze in der biomolekularen Interaktionsanalyse unter besonderer Berücksichtigung pharmazeutischer und lebensmittelchemischer Fragestellungen " . Bonn, Universität, Mathematisch-Naturwissenschaftliche Fakultät, Dissertation, 2004


130. Carbone, D.P., Koros, A.M., Linnoila, R.I., Jewett, P. und Gazdar, A.F.: " Neural cell adhesion molecule expression and messenger RNA splicing patterns in lung cancer cell lines are correlated with neuroendocrine phenotype and growth morphology " . Cancer Research 51 (1991), 6142-6149


131. Kitamura, M.: " NF-kB-mediated self defense of macrophages faced with bacteria " .


132. Berthelot, P., Grattard, F., Ros, A., Lucht, F. und Pozzetto, B.: " Nosocomial legionellosis outbreak over a three-year period: investigation and control " . Clinical Microbiology and Infection 4 (1998), 385-391


133. Römpp Lexikon der Chemie, Online Version 3.2, Stuttgart: Georg Thieme Verlag KG, 2008


134. Kamio, Y. und Nikaido, H.: " Outer membrane of Salmonella typhimurium: accessibility of phospholipid head groups to phospholipase c and cyanogen bromide activated dextran in the external medium " . Biochemistry 15 (1976), Nr.12, 2561-2570


135. Takahashi, T., Nau, M.M., Chiba, I., Birrer, M.J., Rosenberg, R.K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A.F. und Minna, J.D.: " p53:a frequent target for genetic abnormalities in lung cancer " . Science 246 (1989), 491-494


136. Navarre, W.W. und Zychlinsky, A.: " Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies " . Cellular Microbiology 2 (2000), Nr.4, 265-273


137. Schöffski, P., Riggert, S., Fumoleau, P., Campone, M., Bolte, O., Marreaud, S., Lacombe, D., Baron, B., Herold, M., Zwierzina, H., Wilhelm-Ogunbiyi, K., Lentzen, H. und Twelves, C.: " Phase I trial of intravenous aviscumin (rViscumin) in patients with solid tumours: a study of the European Organization for Research and Treatment of Cancer New Drug Development Group " . Annals of Oncology 15 (2004), 1816-1824


138. Sessa, G. und Weissmann, G.: " Phospholipid spherules (liposomes) as a model for biological membranes " . Journal of Lipid Research 9 (1968), 310-318


139. Ganguly, C. und Das, S.: " Plant lectins as inhibitors of tumor growth and modulators of host immune response " . Chemotherapy 40 (1994), 272-278


140. Rüdiger, H. und Gabius, H.J.: " Plant lectins: occurrence, biochemistry, functions and applications " . Glycoconjugate Journal 18 (2001), 589-613


141. Vornholt, W., Seidel, N., Kissel, T. und Keusgen, M: " Poly(ethylene carbonate) degradation studies using macrophages monitored by surface plasmon resonance " , DPhG (Deutsche Pharmazeutische Gesellschaft) Jahrestagung, Erlangen, Oktober 2007


142. Stoll, G.H., Nimmerfall, F., Acemoglu, M., Bodmer, D., Bantle, S., Müller, I., Mahl, A., Kolopp, M. und Tullberg, K.: " Poly(ethylene carbonate)s, part II: degradation mechanisms and parenteral delivery of bioactive agents " . Journal of Controlled Release 76 (2001), 209-225


143. Seftalioglu, A. und Dalcik, H.: " Preparation and application of lectin-gold complexes " . Journal of Islamic Academy of Sciences 7 (1994), Nr.2, 120-129


144. Weetall, H.H.: " Preparation of immobilized proteins covalently coupled through silane coupling agents to inorganic supports " . Applied Biochemistry and Biotechnology 41 (1993), 157-188


145. Olson, F., Hunt, C.A., Szoka, F.C., Vail, W.J. und Papahadjopoulos, D.: "Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes" Biochimica et Biophysica Acta 557 (1979), Nr.1, 9-23


146. Hope, M.J., Bally, M.B., Webb, G. und Cullis, P.R.: "Production of large unilamellar vesicles by a rapid extrusion procedure -characterisation of size distribution, trapped volume and ability to maintain a membrane potential". Biochimica et Biophysica Acta - Biomembranes 812 (1985), Nr.1, 55-65


147. Bryant, M.L., Stoner, G.D. und Metzger, R.P.: " Protein-bound carbohydrate content of normal and tumorous human lung tissue " . Biochimica et Biophysica Acta 343 (1974), 226-231


148. Järnefelt, J., Finne, J., Krusius, T. und Rauvala, H.: " Protein-bound oligosaccharides of cell membranes " . Trends in Biochemical Sciences 3 (1978), 110-114


149. Goldstein, I.J., Hollerman, C.E. und Smith, E.E.: " Protein-carbohydrate interaction. II: Inhibition studies of the interaction of concanavalin A with polysaccharides " . Biochemistry 4 (1965), Nr.5, 876-883


150. Ruef C. und Francioli P.: " Prävention der nosokomialen Legionelleninfektion " . Swiss- NOSO: Nosokomiale Infektionen und Spitalhygiene 4 (1997), Nr.2, 9-12


151. Jäggi, C., Musielski, H., Urech, K. und Schaller, G.: " Quantitative determination of lectins in mistletoe preparations " . Arzneimittel-Forschung 45 (1993), Nr.8, 905-909


152. Wu, J.T.: Quantitative immunoassay: A practical guide for assay establishment, troubleshooting and clinical application. Washington: American Association for Clinical Chemistry, Inc., 2000


153. Kretschmann, E. und Raether, H.: " Radiative decay of non radiative surface plasmons excited by light " . Zeitschrift für Naturforschung Teil A 23 (1968), 2135-2136


154. Ulevitch, R.J. und Tobias, P.S.: " Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin " . Annual Review of Immunology 13 (1995), 437-457


155. Akashi, S., Ogata, H., Kirikae, F., Kirikae, T., Kawasaki, K., Nishijima, M., Shimazu, R., Nagai, Y., Fukudome, K., Kimoto, M. und Miyake, K.: " Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2 " . Biochemical and Biophysical Research Communications 268 (2000), Nr.1, 172-177


156. Baars-Hibbe, H.: Renaturierung von rekombinantem Mitellektin I aus Inclusion Bodies.


157. Tran, A.X., Lester, M.E., Stead, C.M., Raetz, C.R., Maskell, D.J., McGrath, S.C., Cotter, R.J. und Trent, M.S.: " Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A " . The Journal of Biological Chemistry 280 (2005), Nr.31, 28186-28194


158. Barbieri, L., Battelli, M.G. und Stirpe, F.: " Ribosome-inactivating protein from plants " . Biochimica et Biophysica Acta 1154 (1993), 237-282


159. van Damme, E.J.M., Hao, Q., Chen, Y., Barre, A., Vandenbussche, F., Desmyter, S., Rouge´, P. und Peumans, W.J.: " Ribosome-inactivating proteins: a family of plant proteins that do more than inactivating ribosomes " . Critical Reviews in Plant Sciences 20 (2001), 395-465


160. Peumans, W.J., Hao, Q. und Van Damme, E.J.M.: " Ribosome-inactivating proteins from plants: more than RNA N-glycosidases? " The FASEB Journal 15 (2001), 1493-1506


161. Harman, D.: " Role of free radicals in aging and disease " . Annals of the New York Academy of Sciences 673 (1992), 126-141


162. Moldovan, N.I.: " Role of monocytes and macrophages in adult angiogenesis: a light at the tunnel's end " . Journal of Hematotherapy & Stem Cell Research 11 (2002),179-194


163. D'Aoust, J.Y.: " Salmonella species " . In: Doyle, M.P., Beuchat, L.R., Montville, T.H.: Food Microbiology, Fundamentals and Frontiers. Washington, DC: American Society for Microbiology Press, 1997


164. Lloyd, C.W.: " Sialic acid and the social behaviour of cells " . Biological Reviews of the Cambridge Philosophical Society 50 (1975), 325-350


165. Shear, J.B., Fishman. H.A., AIIbritton, N.L., Garigan, D., Zare, R.N. und Scheller, R.H.: " Single cells as biosensors for chemical separations " . Science 267 (1995), 74-77


166. Olson, M.O.J. und Liener, I.E.: " Some physical and chemical properties of concanavalin A, the phytohemagglutinin of the jack bean " . Biochemistry 6 (1967), Nr.1, 105-111


167. Müller, W.E., Arendes, J., Kurelec, B., Zahn, R.K. und Müller, I.: " Species-specific aggregation factor in sponges. Sialyltransferase associated with aggregation factor " . The Journal of Biological Chemistry 252 (1977), 3836-3842


168. Brewer, C.F. und Bhattacharyya, L.: " Specifity of concanavalin A binding to asparaginelinked glycopeptides " . The Journal of Biological Chemistry 261 (1986), Nr.16, 7306-7310


169. Nikitin, P.I., Gorshkov, B.G., Valeiko, M.V. und Rogov, S.I.: " Spectral-phase interference method for detecting biochemical reactions on a surface " . Quantum Electronics 30 (2000), Nr.12, 1099-1104


170. Posterpräsentationen Vornholt, W. und Keusgen, M.: " SPR-Oberflächen zur Immobilisierung von lebenden Zellen " . 4. Deutsches BioSensor Symposium (DBS 2005), Regensburg, März 2005


171. Veröffentlichungen im Rahmen dieser Arbeit Publikationen Vornholt, W., Hartmann, M. und Keusgen, M.: " SPR studies of carbohydrate–lectin interactions as useful tool for screening on lectin sources " . Biosensors and Bioelectronics 22 (2007), 2983-2988


172. Tripathi, S. und Maiti, T.K.: " Stimulation of murine macrophages by native and heatdenatured lectin from Abrus precatorius " . International Immunopharmacology 3 (2003), 375-381


173. Brade, H., Moll, H. und Rietschel, E.T.: " Structural investigations on the inner core region of lipopolysaccharides from Salmonella minnesota rough mutants " . Biomedical Mass Spectrometry 12 (1985), Nr.10, 602-609


174. Seydel, U., Koch, M.H. und Brandenburg, K.: " Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota " . Journal of Structural Biology 110 (1993), Nr.3, 232-243


175. Reeke, G.N. Jr., Becker, J.W., Cunningham, B.A., Wang, J.L., Yahara, I. und Edelman, G.M.: " Structure and function of concanavalin A " . In: Chowdhury, T.K. und Weiss, A.K.: International Symposium on Concanavalin A., Norman, Oklahoma. New York und London: Plenum Press, 1974


176. Schumann, R.R., Leong, S.R., Flaggs, G.W., Gray, P.W., Wright, S.D., Mathison, J.C., Tobias, P.S. und Ulevitch, R.J.: " Structure and function of lipopolysaccharide binding protein " . Science 249 (1990), 1429-1431


177. Tsubery, H., Ofek, I., Cohen, S. und Fridkin, M.: " Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria " . Journal of Medicinal Chemistry 43 (2000), Nr.16, 3085-3092


178. Kornfeld, S. und Kornfeld, R.: " Structure of glycoproteins and their oligosaccharide units " . In: Lennarz, W.J. (Hrsg.): Biochemistry of Glycoproteins and Proteoglycans. New York: Plenum Press, 1980, 1-34


179. Kobata, A.: " Structures and functions of the sugar chains of cell surface glycoproteins " . Cell Structure and Function 4 (1979),169-181


180. Huang C.: " Studies on phosphatidylcholine vesicles. Formation and physical characteristics " . Biochemistry 8 (1969), 344-352


181. Ziska, P. und Franz, H.: " Studies on the interaction of the mistletoe lectin I with carbohydrates " . Experientia 37 (1981), Nr. 3, 219


182. Tonevitsky A.G., Agapov I., Temiakov D., Moisenovich M., Maluchenko N., Solopova O., Würzner G. und Pfueller U.: " Study of heterogeneity of lectins in mistletoe preparations by monoclonal antibodies to their A-subunits " . Arzneimittel-Forschung 49 (1999), Nr.11, 970-975


183. Roche, A.C., Barzilay, M., Midoux, P., Junqua, S., Sharon, N., und Monsigny, M.: " Sugar-specific endocytosis of glycoproteins by Lewis Lung Carcinoma cells " . Journal of Cellular Biochemistry 22 (1983), 131-140


184. Liedberg, B., Nylander, C. und Lundström, I.: " Surface plasmon resonance for gas detection and biosensing " . Sensors and Actuators 4 (1983), Nr.2, 299-304


185. Homola, J., Yee, S.S. und Gauglitz, G.: " Surface plasmon resonance sensors: review " . Sensors and Actuators B 54 (1999), 3-15


186. Vornholt, W. und Keusgen, M: " Surface plasmon resonance (SPR) chip device for screening on lectins and binding of entire cells " . 53rd Annual Congress der Gesellschaft für Arzneipflanzenforschung, Florenz (Italien), August 2005


187. Broner, L.H., Miller, K.R., Owicki, J.C., Parce, J.W. und Muir, V.C.: " Testing ocular irritancy in vitro with the silicon microphysiometer " . Toxicology in Vitro 5 (1991), 277-284


188. Gregoriadis, G.: " The carrier potential of liposomes in biology and medicine (second of two parts) " . The New England Journal of Medicine 295 (1976), 765-770


189. Cunningham, B.A., Wang, J.L., Waxdal, M.J. und Edelmann, G.M.: " The covalent and threedimensional structure of concanavalin A (II. Amino acid sequence of cyanogen bromide fragment F3) " . The Journal of Biological Chemistry 250 (1975), Nr.4, 1503-1512


190. Kanellopoulos, P.N., Pavlou, K., Perrakis, A., Agianian, B., Vorgias, C.E., Mavrommatis, C., Soufi, M., Tucker, P.A. und Hamodrakas, S.J.: " The crystal structure of the complexes of concanavalin A with 4'-nitrophenyl-alpha-D-mannopyranoside and 4'-nitrophenyl-alpha-D-glucopyranoside " . Journal of Structural Biology 116 (1996 b ), Nr.3, 345-355


191. Woof, J.M. und Kerr, M.A.: " The function of immunoglobulin A in immunity " . The Journal of Pathology 208 (2006), Nr.2, 270-282


192. Sumner, J.B.: " The globulins of the jack bean, Canavalia ensiformis " . The Journal of Biological Chemistry 37 (1919), 137-142


193. Luther, P., Theise, H., Chatterjee, B., Karduck, D. und Uhlenbruck, G.: " The lectin from Viscum album L. – isolation, characterisation, properties and structure " . The International Journal of Biochemistry 11 (1980), 429-435


194. Owicki, J.C., Bousse, L., Hafeman, D.G., Kirk, G.L., Olson, J.D., Wada, H.G. und Parce, J.W.: " The light-addressable potentiometric sensor: principles and biological applications " . Annual Review of Biophysics and Biomolecular Structure 23 (1994), 87-113


195. Loris, R., Casset, F., Bouckaert, J., Pletinckx, J., Dao-Thi, M.H., Poortmans, F., Imberty, A., Perez, S. und Wyns, L.: " The monosaccharide binding site of lentil lectin: an X-ray and molecular modelling study " . Glycoconjugate Journal 11 (1994), Nr.6, 507-517


196. Zhang, Q.: " Theoretical analysis and design of submicron-LAPS " . Sensors and Actuators B 105 (2005), 304-311


197. Debray, H.: " The plasma membrane glycoconjugates of normal and transformed cells " . Bulletin du cancer 66 (1979), 353-372


198. Senear, D.F. und Teller, D.C.: " Thermodynamics of concanavalin A dimer-tetramer self association: Sedimentation equilibrium studies " . Biochemistry 20 (1981), Nr.11, 3076-3083


199. Levin, J. und Bang, F.B.: " The role of endotoxin in the extracellular coagulation of limulus blood " . Bulletin of the Johns Hopkins Hospital 115 (1964 b ), 265-274


200. Catroux, P., Rougier, A., Dossou, K.G. und Cottin, M.: " The silicon microphysiometer for testing ocular toxicity in vitro " . Toxicology in Vitro 7 (1993), 465-469


201. Endo, Y., Tsurugi, K. und Franz, F.: " The site of action of the A-chain of mistletoe lectin I on eukaryotic ribosomes. The RNA N-glycosidase activity of the protein " . FEBS Letters 231 (1988), 378-380


202. Lelie, D. van der, Corbisier, P., Baeyens, W., Wuertz, S., Diels, L. und Mergeay, M.: " The use of biosensors for environmental monitoring " . Research in Microbiology 145 (1994), 67-74


203. Pearson, F.C., Caruana, R., Burkart. J., Katz, D.V., Chenoweth, D., Dubczak, J., Bohon, J. und Weary, M.: " The use of the limulus amebocyte lysate assay to monitor hemodialyzerassociated soluble cellulosic material (LAL-reactive material) " . In: Watson, S.W., Levin, J. und Nowitzky, T.J. (Hrsg.): Detection of bacterial endotoxins with the limulus amebocyte lysate test. New York: Alan R. Liss, Inc., 1987, 211-222


204. Drickamer, K.: " Two distinct classes of carbohydrat-recognition domains in animal lectins " . The Journal of Biological Chemistry 263 (1988), Nr.20, 9557-9560


205. Cody, S.H., Abbott, S. L., Marfin, A.A., Schulz, B., Wagner, P., Robbins, K., Mohle- Boetani, J.C. und Vugia, D.J.: " Two outbreaks of multidrug-resistant Salmonella serotype typhimurium DT104 infections linked to raw-milk cheese in Northern California " . Journal of the American Medical Association 281 (1999), Nr.19, 1805–1810


206. Nagata, Y und Burger, M.M.: " Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding " . The Journal of Biological Chemistry 249 (1974), Nr.10, 3116-3122


207. Bousse, L.: " Whole cell biosensors " . Sensors and Actuators. B, Chemical 34 (1996), 270-275


208. Rawson, D.M., Willmer, A.J. und Turner, A.P.: " Whole cell biosensors for environmental monitoring " . Biosensors 4 (1989), 299-311


209. Meusel, M. und Vering, T.: " Workshop report: concerted action''Biosensor Stability'' in the EC-program on industrial and materials technologies (BRITE-EURAM) " . Biosensors & Bioelectronics 13 (1998), IX–XI Mikeska, R., Wacker, R., Arni, R., Singh, T.P., Mikhailov, A., Gabdoulkhakov, A., Voelter, W. und Betze, C.: " Mistletoe lectin I in complex with galactose and lactose reveals distinct sugar-binding properties " . Acta Crystallographica. Section F, Structural Biology and Crystallization Communications F61 (2005), 17-25


210. Ruckdeschel, K., Mannel, O., Richter, K., Jacobi, C.A., Trülzsch, K., Rouot, B. und Heesemann, J.: " Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-κB pathway and exploits lipopolysaccharide signaling to trigger apotosis in macrophages " . Journal of Immunology 166 (2001), Nr.3, 1823-1831


211. Warren, L., Zeidman, I. und Buck, C.A.: " The surface glycoproteins of a mouse melanoma growing in culture and as a solid tumor in vivo " . Cancer Research 35 (1975), 2186-2190


212. Ruscetti, F.W. und Chervenick, P.A.: " Regulation of the release of colony-stimulating activity from mitogen-stimulated lymphocytes " . Journal of Immunology 114 (1975), Nr.5, 1513-1517


213. Rollins, B.J. und Culp, L.A.: " Glycosaminoglycan in the substrate adhesion sites of normal and transformed murine cells " . Biochemistry 18 (1979), 141-148


214. Beitze-Breyhan, K.: Der Einfluss von Fucoidin auf das Entstehen von sekundärem Lungen-und Leberversagen in einem two-hit Modell von Ischämie und Reperfusion und caecaler Ligation und Punktion in der Maus. Hannover, Tierärztliche Hochschule, Institut für Pharmakologie, Toxikologie und Pharmazie, Dissertation, 2000


215. Basler, T.: Mechanismen der Mykobakterien-abhängigen Modulation von Makrophagen und deren Auswirkungen auf Enterozyten. Hannover, Tierärztliche Hochschule, Fachbereich Mikrobiologie, Dissertation, 2006


216. Smith, E.A., Thomas, W.D., Kiessling, L.L. und Corn, R.R.: " Surface plasmon resonance imaging studies of protein-carbohydrate interactions " . Journal of the American Chemical Society 125 (2003), Nr.20, 6140-6148


217. Schwarz, F.P., Puri, K.D., Bhat, R.G. und Surolia, A.: " Thermodynamics of monosaccharide binding to concanavalin A, pea (Pisum sativum) lectin and lentil (Lens culinaris) lectin " . The Journal of Biological Chemistry 268 (1993), Nr.11, 7668-7677


218. Pathak, S.S. und Savelkoul, H.F.: " Biosensors in immunology: the story so far " . Immunology Today 18 (1997), Nr.10, 464-467


219. Schink, M., Moser, D. und Mechelke, F.: " Two-dimensional isolectin patterns of the lectins from Viscum album L. (mistletoe) " . Naturwissenschaften 79 (1992), 80-81


220. Tan, H.M., Cheong, S.P. und Tan, T.C.: " An amperometric benzene sensor using whole cell Pseudomonas putida ML2 " . Biosensors & Bioelectronics 9 (1994), 1-8


221. Rogers, K.R.: " Biosensors for environmental applications " . Biosensors & Bioelectronics 10 (1995), 533-541


222. Franz, H., Ziska, P. und Kindt, A.: " Isolation and properties of three lectins from mistletoe (Viscum album L.) " . The Biochemical Journal 195 (1981), 481-484


223. Clarke, A.E. und Denborough, M.A.: " The interaction of concanavalin A with blood- groupsubstance glycoproteins from human secretions " . Biochemical Journal 121 (1971), Nr.5, 811-816


224. Danner, R.L., Joiner, K.A., Rubin, M., Patterson, W.H., Johnson, N., Ayers, K.M. und Parrillo, J.E.: " Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide " . Antimicrobial Agents and Chemotherapy 33 (1989), 1428-1434


225. Moore, R.A., Bates, N.C. und Hancock, R.E.: " Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl- polymyxin " . Antimicrobial Agents and Chemotherapy 29 (1986), 496-500


226. Duwe, A.K., Rupar, C.A., Horsman, G.B. und Vas, S.I.: " In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide " . Antimicrobial Agents and Chemotherapy 30 (1986), 340-341


227. Sonesson, A., Larsson, L., Schütz, A., Hagmar, L. und Hallberg, T.: " Comparison of the limulus amebocyte lysate test and gas chromatography-mass spectrometry for measuring lipopolysaccharides (endotoxins) in airborne dust from poultry-processing industries " . Applied and Environmental Microbiology 56 (1990), Nr.5, 1271-1278


228. Rock, F.L., Hardiman, G., Timans, J.C., Kastelein, R.A. und Bazan, J.F.: " A family of human receptors structurally related to Drosophila Toll " . Proceedings of the National Academy of Sciences of the United States of America 95 (1998), 588-593


229. Vaara, M. und Vaara, T.: " Polycations sensitize enteric bacteria to antibiotics " . Antimicrobial Agents and Chemotherapy 24 (1983),Nr.1, 107-113


230. Heitzer, A., Malachowsky, K., Thonnard, J.E., Bienkowski, P.R., White, D.C. und Sayler, G.S.: " Optical biosensor for environmental on-line monitoring of naphthalene and salicylate bioavailability with an immobilized bioluminescent catabolic reporter bacterium " . Applied and Environmental Microbiology 60 (1994), 1487-1494


231. Bittiger, H.S. und Schnebli, H.P.: Concanavalin A as a tool. London: John Wiley & Sons, 1976


232. Maitra, S.K., Nachum, R. und Pearson, F.C.: " Establishment of beta-hydroxy fatty acids as chemical marker molecules for bacterial endotoxin by gas chromatography-mass spectrometry " . Applied and Environmental Microbiology 52 (1986), 510-514


233. Stoolman, L.M. und Rosen, S.D.: " Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation " . The Journal of Cell Biology 96 (1983), 722-729


234. Monack, D.M., Mecsas, J., Ghori, N. und Falkow, S.: " Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death " . Proceedings of the National Academy of Sciences of the United States of America 94 (1997), Nr.19, 10385-10390


235. Antalis, C., Fogel, S. und Ballou, C.E.: " Genetic control of yeast mannan structure " . The Journal of Biological Chemistry 248 (1973), Nr.13, 4655-4659


236. van Furth, R., Cohn, Z.A., Hirsch, J.G., Humphrey, J.H., Spector, W.G. und Langevoort, H.L.: " The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells " . Bulletin of the World Health Organization 46 (1972), 845-852


237. Ofek, I., Cohen, S., Rahmani, R., Kabha, K., Herzig, Y. und Rubinstein, E.: " Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice " . Antimicrobial Agents and Chemotherapy 38 (1994), 374-377


238. Funahara, Y. und Nikaido, H.: " Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium " . Journal of Bacteriology 141 (1980), Nr.3, 1463-1465


239. Nikaido, H. und Vaara, M.: " Molecular basis of bacterial outer membrane permeability " . Microbiological Reviews 49 (1985), Nr.1, 1-32


240. Suzuki, T., Kobayashi, M., Isatsu, K., Nishihara, T., Aiuchi, T., Nakaya, K. und Hasegawa, K.: " Mechanisms involved in apoptosis of human macrophages induced by lipopolysaccharide from Actinobacillus actinomycetemcomitans in the presence of cycloheximide " . Infection and Immunity 72 (2004), Nr.4, 1856-1865


241. Möller, W., Brown, D., Kreyling, W. und Stone, V.: " Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium " . Particle and Fibre Toxicology 2 (2005), 7


242. Owicki, J.C. und Parce, J.W.: " Biosensors based on the energy metabolism of living cells: the physical chemistry and cell biology of extracellular acidification " . Biosensors & Bioelectronics 7 (1992), 255-272


243. Gaisford, W.C., Richardson, N.J., Haggett, B.G.D. und Rawson, D.M.: " Microbial biosensors for environmental monitoring " . Biochemical Society Transactions 19 (1991), 15-18