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Wheezing is a lung
sound phenomenon observed during bronchial obstruction. Here,
bronchial asthma is most relevant. Issues Aim of the present
thesis was to detect wheezing during provoked bronchial
obstruction. Further it was questioned if the occurrence of
wheezing leads to higher specic airway resistance and, vice
versa, if a increasing specic airway resistance leads to
wheezing. Materials and Methods For 25 patients, 7 female and
18 male (age 4318a), with bronchial asthma or a
hyper-responsive bronchial system methacholine provocation
tests according to the guidelines of the German Society of
allergology and clinical immunology were conducted. After
each provocation level lung function parameters were
measured. The lung sounds were recorded and subsequently the
results were compared with measured lung function parameters.
Results For 9 out of 25 patients wheezing was observed.
Wheezing was found for 5 patients without provocation and for
4 patients after provocation. Non of the patients ever showed
wheezing after broncholysis. The threshold of the specic
airway resistance for the occurrence of wheezing is sRtot =
2,0kPa/l/s. In the group of non-wheezing patients no wheezing
was found for 8 out of 16 Patients even though the sRtot did
exceed 2,0kPa/l/s. For patients with wheezing a signicant
steeper increase of the specic airway resistance in
comparison with the group of non-wheezing patients is found.
Discussion Although double-sided wheezing is always an
indication for a bronchial obstruction (own investigations),
the results presented here prove the specic airway resistance
is not suited to predict the occurrence of wheezing.