Untersuchung der Hemisphärendominanz während mentaler Rotation mittels funktioneller Magnetresonanztomographie und funktioneller transkranieller Dopplersonographie

Die Fähigkeit zur mentalen Rotation (MR) von Objekten ist eine komplexe kognitive Aufgabe, deren neurale Korrelate bisher kontrovers diskutiert wurden, da es weder in Bezug auf eine hemisphärenspezifische Dominanz, noch auf spezifisch aktivierte kortikale Areale oder geschlechterspezifische Untersch...

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Bibliographic Details
Main Author: Plate, Annika
Contributors: Knake, Susanne (Prof. Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2010
Nervenheilkunde
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Table of Contents: The aim of the present study was to investigate specific activation patterns and potential gender differences during mental rotation and to investigate whether fMRI and fTCD lateralize hemispheric dominance concordantly. Regional brain activation and hemispheric dominance during mental rotation (cube perspective test) were investigated in ten female and ten male healthy subjects using fMRI and fTCD. Our findings indicate that the neural basis of mental rotation depends on a widespread bilateral network: Significant activation was found in the superior parietal lobe, at the parieto-occipital border, in the middle and superior frontal gyrus bilaterally and the right inferior frontal gyrus. Men tended to show more activation in the right hemisphere using fTCD and more activation in frontal and parieto-occiptal regions of the right hemisphere using fMRI. Hemispheric dominance for mental rotation determined by fMRI and fTCD correlated well, but did not show concordant results in every single subject. Hemispheric lateralization of complex cortical functions such as spatial rotation therefore should be investigated using multimodal imaging approaches, especially if used clinically as a tool for the presurgical evaluation of patients undergoing neurosurgery.