Der vaskuläre endotheliale Wachstumsfaktor VEGF hemmt die Endothelzellapoptose über Regulation von PARP

Der vaskuläre endotheliale Wachstumsfaktor (VEGF) ist der stärkste Überlebensfaktor für Endothelzellen. Der anti-apoptotische Effekt von VEGF auf das Endothel ist allgemein bekannt, jedoch sind die Mechanismen, die zu der Apoptosehemmung führen, weitgehend unbekannt. Daher wurde die Hypothese unters...

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Bibliographische Detailangaben
1. Verfasser: Hörmann, Mareike
Beteiligte: Al-Fakhri, Nadia (PD Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Sprache:Deutsch
Veröffentlicht: Philipps-Universität Marburg 2010
Medizin
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1. Liu B, Fang M, Lu Y, Mills GB, Fan Z. Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells. Br J Cancer 2001; 85: 303-311


2. Haunstetter A, Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res 1998; 82: 1111-1129


3. Mallat Z, Benamer H, Hugel B, Benessiano J, Steg PG, Freyssinet JM, Tedgui A. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndrome. Circulation 2000; 101: 841-843


4. Janknecht R, Ernst WH, Pingoud V, Nordheim A. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J 1993; 12 (13): 5097-5104 ~ 103 ~


5. Dimmeler S, Zeiher AM. Akt takes center stage in angiogenesis signalling. Circ Res 2000; 86: 4-5


6. Kerr JFR, Wyllie AH, Currie AR. Apoptosis a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257


7. Lawen A. Apoptosis-an introduction. BioEssays 2003; 25: 888-896 ~ 104 ~


8. Isner JM, Kearney M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995; 91: 2703-2711


9. Dimmeler S, Herrmann C, Zeiher AM. Apoptosis of endothelial cells. Contribution to the pathology of atherosclerosis? Eur Cytokine Netw 1998; 9: 697-698


10. Fadok VA, Warner ML, Bratton DL, Henson PM. CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phophatidylserine receptor or the vitronectin receptor (αvß3). J Immunol 1998; 161: 6250-6257


11. Laemmli UK. Cleavage of structural proteins during assembly of head of bacteriophage-T4. Nature 1970; 227: 680-685


12. Mallat Z, Ohan J, Lesèche G, Tedgui A. Colocalization of CCP-32 with apoptotic cells in human atherosclerotic plaques. Circulation 1997; 96: 424- 428


13. Hedin U, Roy J, Tran PK. Control of smooth muscle cell proliferation in vascular disease. Curr Opin Lipidol 2004; 15: 559-565


14. Fadok VA, Savill JS, Haslett C, Bratton DL, Doherty DE, Campell PA, Henson PM. Different populations of macrophages use either the vitronectin receptor or the phophatidylserine receptor to recognize and remove apoptotic cells. J Immunol 1992; 149: 4029-4035


15. Futami R, Miyashita M, Nomura T, Makino H, Matsutani T, Sasajima K, Tajiri T. Increased serum vascular endothelial growth factor following major surgical injury. J Nippon Med Sch 2007; 74 (3): 223-229


16. Kim SJ. Insulin rapidly induces nuclear translocation of PI3-kinase in HepG2 cells. Biochem Mol Biol Int 1998; 46: 187-196


17. Kim KY, Kim SO, Lim H, Yoo SE, Hong KW. KR-31372 inhibits KDR/Flk-1 tyrosine phosphorylation via K+ (ATP) channel opening in its antiangiogenic effect. Eur J Pharmacol 2003; 465 (3): 219-228


18. Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase pathways activated by stress and inflammation. Physiol Rev 2001; 81 (2): 807-869


19. Downward J. Mechanisms and consequences of activation of protein kinase PI3/Akt. Curr Opin Cell Biol 1998; 10: 262-267


20. Eccles SA, Welch DR. Metastasis: recent discoveries and novel treatment strategies. Lancet 2007; 369(9574): 1742-1757


21. Geng YJ. Molecular signal transduction in vascular cell apoptosis. Cell Research 2001; 11(4): 253-264 ~ 102 ~


22. Kowentz-Leutz E, Twamley G, Ansieau S, Leutz A. Novel mechanism of C/EBP beta (NF-M) transcriptional control: actvation through derepression.


23. Irani K. Oxidant signalling in vascular cell growth, death, and survival-a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signalling. Circ Res 2000; 87: 179- 183


24. Marchisio M, Bertagnolo V, Colamussi ML, Capitani S, Neri LM. Phophatidylinositol 3-kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation. Biochem Biophys Res Commun 1998; 253: 346-351


25. Lu PJ, Hsu AL, Wang DS, Yan HY, Yin HL, Chen CS. Phosphoionisitide 3- kinase in rat liver nuclei. Biochemistry 1998; 37: 5738-5745


26. Lum H, Malik AB. Regulation of vascular endothelial barrier function. Am J Physiol 1994; 267: 223-241


27. Fujikawa K, De Aos Scherpenseel I, Jain SK, Presman E, Varticovski L. Role of PI 3-Kinase in angiopoietin-1-mediated migration and attachement- dependent survival of endothelial cells. Exp Cell Res 1999; 253: 663-672


28. Isacke C, Horton M. The adhesion molecule facts book. 2 nd Edition, London: Academic Press 2000: 187ff.


29. Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998; 8: 267-271


30. Marais R, Wynne J, Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 1993; 73: 381-393


31. Holvoet P, Collen D. Thrombosis and atherosclerosis. Curr Opin Lipidol 1997; 8 (5): 320-328


32. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-Kinase/Akt signal transduction pathway. J Biol Chem 1998a; 273 (46): 30336-30343


33. Juretic N, Santibanez JF, Hurtado C, Martinez J. ERK 1, 2 and p38 pathways are involved in proliferative stimuli mediated by urokinase in SaOS-2 cell line. J Cell Biochem 2001; 83 (1): 92-98


34. Kaiser D, Freyberg MA, Friedl P. Lack of hemodynamic forces triggers apoptosis in vascular endothelial cells. Biochem Biophys Res Commun 1997; 231: 586-590


35. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science 2002; 298: 1911- 1912


36. Levkau B, Herren B, Koyama H, Ross R, Raines EW. Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis. J Exp Red 1998; 187: 579- 586


37. Fujio Y, Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 1999; 274: 16349-16354


38. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc Natl Acad Sci USA 1983; 80: 3734-3737


39. Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, Cobb MH, Shaw PE. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 1995; 14(5): 951-962


40. Gotlieb AI, Silver MD. Atherosclerosis: pathology and pathogenesis. In: Silver MD, Gotlieb AI, Schoen FJ: Cardiovascular pathology. 3 rd Edition, Philadelphia/PA: Churchill/Livingstone; 2001: 68-106