Toxicological Evaluation of Poly(ethylene imine) -based non-viral vector systems for pulmonary siRNA application

Toxicological Evaluation of Poly(ethylene imine) -based non-viral vector systems for pulmonary siRNA application

In this thesis, toxicity of PEI-based non-viral vector systems for siRNA application into the lungs was comprehensively described and analyzed in vitro as well as in vivo. Chapter 1 introduced in basic information about the lung anatomy and physiology and general considerations for pulmonary appli...

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Dettagli Bibliografici
Autore principale: Beyerle, Andrea
Altri autori: Kissel, Thomas (Prof.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2010
Soggetti:
inflammation
Polyethylenimin (PEI)
pulmonary application
RNS-Interferenz
siRNA
Toxikologische Bewertung
Naturwissenschaften
Cytotoxicity
Wasserlösliche Polymere
Oxidativer Stress
Entzündung
In vivo
Lunge
Cytotoxizität
In vitro
Poly(ethylene imine)
oxidative stress
Natural sciences & mathematics
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