The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The presented study contributes to the fundamental understanding of molecular recognition of small molecules by a macromolecular host protein. The biophysical properties of a large set of systematically varied thrombin inhibitors were anatomized in detail. In particular the combination of structural...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Glavni avtor: Baum, Bernhard
Drugi avtorji: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format: Dissertation
Jezik:angleščina
Izdano: Philipps-Universität Marburg 2009
Teme:
Thermodynamik
Wirkstoffdesign
Kristallographie
Mikrokalorimetrie
Structure based drug-design
Thrombin
Arzneimitteldesign
Naturwissenschaften
Natural sciences & mathematics
Online dostop:PDF-Volltext
Oznake: Označite
Brez oznak, prvi označite!

Internet

PDF-Volltext

Podrobnosti zaloge
Signatura: urn:nbn:de:hebis:04-z2009-06981
Publikationsdatum: 2009-11-24
Datum der Annahme: 2009-08-28
Downloads: 59 (2024), 148 (2023), 204 (2022), 240 (2021), 330 (2020), 289 (2019), 131 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Zugangs-URL: https://archiv.ub.uni-marburg.de/diss/z2009/0698
https://doi.org/10.17192/z2009.0698

Podobne knjige/članki