The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The well-tempered Thrombin - A systematic crystallographic and calorimetric study on the thermodynamics of serine-protease inhibition

The presented study contributes to the fundamental understanding of molecular recognition of small molecules by a macromolecular host protein. The biophysical properties of a large set of systematically varied thrombin inhibitors were anatomized in detail. In particular the combination of structural...

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Bibliografische gegevens
Hoofdauteur: Baum, Bernhard
Andere auteurs: Klebe, Gerhard (Prof. Dr.) (Thesis begeleider)
Formaat: Dissertation
Taal:Engels
Gepubliceerd in: Philipps-Universität Marburg 2009
Onderwerpen:
Thermodynamik
Wirkstoffdesign
Kristallographie
Mikrokalorimetrie
Structure based drug-design
Thrombin
Arzneimitteldesign
Naturwissenschaften
Natural sciences & mathematics
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Plaatsingsnummer: urn:nbn:de:hebis:04-z2009-06981
Publicatiedatum: 2009-11-24
Datum der Annahme: 2009-08-28
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Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL naar item: https://archiv.ub.uni-marburg.de/diss/z2009/0698
https://doi.org/10.17192/z2009.0698

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