Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design

Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens...

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Đã lưu trong:
Chi tiết về thư mục
Tác giả chính: Hoffmann-Geim, Frank
Tác giả khác: Buckel, Wolfgang (Prof. Dr.) (Cố vấn luận án)
Định dạng: Dissertation
Ngôn ngữ:Tiếng Anh
Được phát hành: Philipps-Universität Marburg 2009
Những chủ đề:
Modellierung
Drug Design
Biowissenschaften, Biologie
3alpha HSD/CR
Carbonyl-Reductase
Hydroxysteroid-Dehydrogenasen
Röntgenstruktur
Simulation
Molekulardynamik
Molecular dynamic
Hydroxysteroiddehydrogenase
SDR
Life sciences
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Miêu tả
Tóm tắt:Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds. Carbonyl-reducing enzymes are grouped into two large protein superfamilies, the aldo-keto reductases (AKR) and the short-chain dehydrogenases/reductases (SDR). Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs. In addition, there exist a variety of pluripotent hydroxysteroid dehydrogenases (HSDs) of both superfamilies which specifically catalyze the oxidoreduction at different positions of the steroid nucleus, and which also catalyze rather non-specifically the reductive metabolism of a great number of non-steroidal carbonyl compounds. The present review summarizes recent findings on car-bonyl reductases and pluripotent HSDs of the SDR protein superfamily.
Mô tả vật lý:217 Seiten
số ISBN:978-3-8366-3391-8
DOI:10.17192/z2009.0563

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