The Role of the Mitotic Spindle Checkpoint in Chemotherapy-Induced Apoptosis

The Role of the Mitotic Spindle Checkpoint in Chemotherapy-Induced Apoptosis

The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper chromosome segregation during mitosis by inhibiting the onset of anaphase until all chromosomes are properly aligned. It requires a group of highly conserved proteins including Mad1, Mad2, Bub1, BubR1,...

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Autore principale: Vogel, Celia
Altri autori: Bastians, Holger (Dr.) (Relatore della tesi)
Natura: Dissertation
Lingua:inglese
Pubblicazione: Philipps-Universität Marburg 2008
Soggetti:
Mitotic catastrophe
Apoptose
Chemotherapie
Mitotic spindle checkpoint
Chemotherapy
Mitotische Katastrophe
Apoptosis
Mitotischer Spindelcheckpoint
Zellzyklus
Medizin
Cell cycle
Medical sciences Medicine
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