Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

Böttcher, Jark

Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

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Bibliographische Detailangaben
1. Verfasser:	Böttcher, Jark
Beteiligte:	Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Format:	Dissertation
Sprache:	Englisch
Veröffentlicht:	Philipps-Universität Marburg 2008
Schlagworte:	HIV protease Protein crystallography HIV-Proteaseinhibitor Pyrrolidines Chemie Molekulardesign Strukturbasiertes Wirkstoffdesign Structure-based inhibitor design Proteinkristallographie Arzneimitteldesign Pyrrolidinderivate Chemistry & allied sciences
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Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

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