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Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors
As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...
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| Главный автор: | |
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| Другие авторы: | |
| Формат: | Dissertation |
| Язык: | английский |
| Опубликовано: |
Philipps-Universität Marburg
2008
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| Предметы: | |
| Online-ссылка: | PDF-полный текст |
| Метки: |
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Internet
PDF-полный текст| Шифр: |
urn:nbn:de:hebis:04-z2009-00750 |
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| Дата публикации: |
2009-03-03 |
| Datum der Annahme: |
2008-11-21 |
| Downloads: |
40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018) |
| Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
| Доступ через URL: |
https://archiv.ub.uni-marburg.de/diss/z2009/0075 https://doi.org/10.17192/z2009.0075 |