Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Autor principal: Böttcher, Jark
Outros Autores: Klebe, Gerhard (Prof. Dr.) (Orientador)
Formato: Dissertation
Idioma:inglês
Publicado em: Philipps-Universität Marburg 2008
Assuntos:
Strukturbasiertes Wirkstoffdesign
HIV-Proteaseinhibitor
Chemie
Molekulardesign
Pyrrolidines
Proteinkristallographie
Structure-based inhibitor design
HIV protease
Arzneimitteldesign
Pyrrolidinderivate
Protein crystallography
Chemistry & allied sciences
Acesso em linha:Texto Completo em Formato PDF
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Internet

Texto Completo em Formato PDF

Detalhes do Exemplar
Número de Chamada: urn:nbn:de:hebis:04-z2009-00750
Data de Publicação: 2009-03-03
Datum der Annahme: 2008-11-21
Downloads: 40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Acessar a URL: https://archiv.ub.uni-marburg.de/diss/z2009/0075
https://doi.org/10.17192/z2009.0075

Registros relacionados