Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors
As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...
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Formaat: | Dissertation |
Taal: | Engels |
Gepubliceerd in: |
Philipps-Universität Marburg
2008
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Onderwerpen: | |
Online toegang: | PDF Full text |
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PDF Full textPlaatsingsnummer: |
urn:nbn:de:hebis:04-z2009-00750 |
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Publicatiedatum: |
2009-03-03 |
Datum der Annahme: |
2008-11-21 |
Downloads: |
40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL naar item: |
https://archiv.ub.uni-marburg.de/diss/z2009/0075 https://doi.org/10.17192/z2009.0075 |