Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors
As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...
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Daljnji autori: | |
Format: | Dissertation |
Jezik: | engleski |
Izdano: |
Philipps-Universität Marburg
2008
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Teme: | |
Online pristup: | PDF cijeli tekst |
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Internet
PDF cijeli tekstSignatura: |
urn:nbn:de:hebis:04-z2009-00750 |
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Datum izdanja: |
2009-03-03 |
Datum der Annahme: |
2008-11-21 |
Downloads: |
40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL pristupa: |
https://archiv.ub.uni-marburg.de/diss/z2009/0075 https://doi.org/10.17192/z2009.0075 |