Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors
As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...
Enregistré dans:
Auteur principal: | |
---|---|
Autres auteurs: | |
Format: | Dissertation |
Langue: | anglais |
Publié: |
Philipps-Universität Marburg
2008
|
Sujets: | |
Accès en ligne: | Texte intégral en PDF |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Internet
Texte intégral en PDFCote: |
urn:nbn:de:hebis:04-z2009-00750 |
---|---|
Date de publication: |
2009-03-03 |
Datum der Annahme: |
2008-11-21 |
Downloads: |
40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL d'accès: |
https://archiv.ub.uni-marburg.de/diss/z2009/0075 https://doi.org/10.17192/z2009.0075 |