Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijä: Böttcher, Jark
Muut tekijät: Klebe, Gerhard (Prof. Dr.) (BetreuerIn (Doktorarbeit))
Aineistotyyppi: Dissertation
Kieli:englanti
Julkaistu: Philipps-Universität Marburg 2008
Aiheet:
Strukturbasiertes Wirkstoffdesign
HIV-Proteaseinhibitor
Chemie
Molekulardesign
Pyrrolidines
Proteinkristallographie
Structure-based inhibitor design
HIV protease
Arzneimitteldesign
Pyrrolidinderivate
Protein crystallography
Chemistry & allied sciences
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Internet

PDF-kokoteksti

Saatavuus:
Hyllypaikka: urn:nbn:de:hebis:04-z2009-00750
Julkaisupäivä: 2009-03-03
Datum der Annahme: 2008-11-21
Downloads: 40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
Linkki aineistoon: https://archiv.ub.uni-marburg.de/diss/z2009/0075
https://doi.org/10.17192/z2009.0075

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