Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors
As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...
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Formato: | Dissertation |
Lenguaje: | inglés |
Publicado: |
Philipps-Universität Marburg
2008
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Materias: | |
Acceso en línea: | Texto Completo PDF |
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Internet
Texto Completo PDFNúmero de Clasificación: |
urn:nbn:de:hebis:04-z2009-00750 |
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Fecha de Publicación: |
2009-03-03 |
Datum der Annahme: |
2008-11-21 |
Downloads: |
40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018) |
Lizenz: |
https://rightsstatements.org/vocab/InC-NC/1.0/ |
URL de Acceso: |
https://archiv.ub.uni-marburg.de/diss/z2009/0075 https://doi.org/10.17192/z2009.0075 |