Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

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Bibliographic Details
Main Author: Böttcher, Jark
Contributors: Klebe, Gerhard (Prof. Dr.) (Thesis advisor)
Format: Doctoral Thesis
Language:English
Published: Philipps-Universität Marburg 2008
Subjects:
Strukturbasiertes Wirkstoffdesign
HIV-Proteaseinhibitor
Chemie
Molekulardesign
Pyrrolidines
Proteinkristallographie
Structure-based inhibitor design
HIV protease
Arzneimitteldesign
Pyrrolidinderivate
Protein crystallography
Chemistry & allied sciences
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Call Number: urn:nbn:de:hebis:04-z2009-00750
Publication Date: 2009-03-03
Date of Acceptance: 2008-11-21
Downloads: 40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018)
License: https://rightsstatements.org/vocab/InC-NC/1.0/
Access URL: https://archiv.ub.uni-marburg.de/diss/z2009/0075
https://doi.org/10.17192/z2009.0075

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