Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

Structure-based Development of Secondary Amines as Aspartic Protease Inhibitors

As novel promising scaffold for HIV protease inhibition pyrrolidine-derived inhibitors have recently been reported. In this thesis the stepwise improvement of this compound class to potent inhibitors of wildtype as well as selected mutant proteases utilizing rational drug discovery methods is report...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awdur: Böttcher, Jark
Awduron Eraill: Klebe, Gerhard (Prof. Dr.) (Cynghorydd traethodau ymchwil)
Fformat: Dissertation
Iaith:Saesneg
Cyhoeddwyd: Philipps-Universität Marburg 2008
Pynciau:
Strukturbasiertes Wirkstoffdesign
HIV-Proteaseinhibitor
Chemie
Molekulardesign
Pyrrolidines
Proteinkristallographie
Structure-based inhibitor design
HIV protease
Arzneimitteldesign
Pyrrolidinderivate
Protein crystallography
Chemistry & allied sciences
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Manylion daliadau o
Rhif Galw: urn:nbn:de:hebis:04-z2009-00750
Dyddiad Cyhoeddi: 2009-03-03
Datum der Annahme: 2008-11-21
Downloads: 40 (2024), 59 (2023), 230 (2022), 200 (2021), 159 (2020), 183 (2019), 225 (2018)
Lizenz: https://rightsstatements.org/vocab/InC-NC/1.0/
URL mynediad: https://archiv.ub.uni-marburg.de/diss/z2009/0075
https://doi.org/10.17192/z2009.0075

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