Protonen- und Elektronenströme in humanen Monozyten

Protonen- und Elektronenströme in humanen Monozyten

In dieser Arbeit sind Protonen- und Elektronenströme in humanen Monozyten simultan mit Hilfe der „Patch-Clamp“-Technik gemessen worden. Sie untersucht den durch die NADPHox generierten Elektronenstrom in anderen Zellen als Eosinophilen, Neutrophilen und Osteoklasten. Die Produktion von Sauerstoff...

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Bibliografski detalji
Glavni autor: Musset, Boris
Daljnji autori: Voigt, Karlheinz (Prof. Dr.) (Savjetnik disertacije)
Format: Dissertation
Jezik:njemački
Izdano: Philipps-Universität Marburg 2008
Teme:
H2O2
PKC
Spannungssensor
Proton
Phagocyt
Sauerstoffradikale
Electron
Phagozyt
Immunsystem
Elektrophysiologie
Radikal <Chemie>
Phagozytose
Patch-Clamp-Methode
Medizin
Monocyt
Zink
Protonenstrom
Monozyt
Medical sciences Medicine
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Proton and electron current was simultan measured in this publication using the patch clamp technique. Protoncurrent in human Monocytes do have the same biophysical characteristics than in other human phagocytes. But in contrary neutrophils and eosinophils it is possible to cultivate them for longer periods in vitro. Flourescence measurements confirmed the electrophysiological results. This work contributes to the understanding of the respiratory burst and its function plus the intracellular mechanism.

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