Die Rolle des FISH-Schnelltests in der Pränatalen Diagnostik

Mit Hilfe des Pränatalen Schnelltests (FISH, PCR) können in der heutigen Zeit innerhalb von 24 Stunden die in der Pränatalen Diagnostik am häufigsten auftretenden nummerische Anomalien, wie die Trisomie 21, 18 und 13 sowie gonosomale Aberrationen (z.B. Turner-Syndrom, Klinfelter-Syndrom) erkannt wer...

Full description

Saved in:
Bibliographic Details
Main Author: Beier-Krämer, Christine Maria
Contributors: Fritz, Barbara (Dr.) (Thesis advisor)
Format: Dissertation
Language:German
Published: Philipps-Universität Marburg 2008
Humangenetik
Subjects:
Online Access:PDF Full Text
Tags: Add Tag
No Tags, Be the first to tag this record!
Table of Contents: With the help of an retrospective study we explored the role of Fluoreszenz-in-situ-Hybridisation in Prenatal Diagnostics. We had 958 cases, which were spread into 921 amnicentesis, 33 chorionic villus samplings and 3 fetal blood analysis and 1 punction of the pleura. The study showed that the FISH-method ist valid to be used in Prenatal Diagnostics. There were no false-positiv cases and only 3 false-negative cases. All in all we had an sensitivity of 92% and a specivity of 100%. We suggest to use FISH-testing in combination to conventional chromosome-testing.