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Transcriptional Control Mechanisms of the Uncoupling Protein 3 Gene and their Functional Implications
All proposed hypotheses regarding the physiological function of Ucp3 are at least in part based on the transcriptional regulation of this gene. This fact illustrates how important knowledge of the regulation of a gene is to be able to infer its role. Our mutant hamster model, however, could not b...
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| פורמט: | Dissertation |
| שפה: | אנגלית |
| יצא לאור: |
Philipps-Universität Marburg
2007
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| גישה מקוונת: | PDF-Volltext |
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| סיכום: | All proposed hypotheses regarding the physiological function of Ucp3 are at least in part
based on the transcriptional regulation of this gene. This fact illustrates how important
knowledge of the regulation of a gene is to be able to infer its role. Our mutant hamster
model, however, could not be fully explained by the existing model of transcriptional control
and thereby challenged its integrity.
During my PhD study period I addressed open questions on Ucp3 regulation employing two
parallel approaches. On the one hand our mutant hamster model served as a tool to identify
the unknown regulatory pathway affected by this mutation. On the other hand an unbiased
analysis of the hamster Ucp3 promoter aimed at the identification and verification of so far
unknown transcription factor binding sites. |
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| DOI: | 10.17192/z2007.0785 |